puc-header

Acetylcholine Regulates Olfactory Perceptual Learning Through Effects on Adult Neurogenesis

31 Pages Posted: 3 Jun 2019 Sneak Peek Status: Review Complete

See all articles by Arielle Schilit Nitenson

Arielle Schilit Nitenson

Brown University

Gabriela Manzano-Nieves

Brown University

Devon Lynn Poeta

Brown University

Ryan Bahar

Brown University

Carolyn Rachofsky

Brown University

Nathalie Mandairon

Lyon Neuroscience Research Center

Kevin G. Bath

Brown University - Department of Cognitive, Linguistic and Psychological Sciences

More...

Abstract

Learning to perceptually discriminate between chemical signals in the environment [olfactory perceptual learning (OPL)] is critical for survival. Multiple mechanisms have been implicated in olfactory perceptual learning, including modulation of neurogenesis and manipulation of cholinergic activity. However, whether these represent distinct processes regulating OPL or if cholinergic effects on OPL depend upon neurogenesis has remained an unresolved question. Using a combination of pharmacological and optogenetic approaches, cholinergic activity was shown to be both necessary and sufficient to drive OPL, and this process was dependent upon the presence of newly born cells in the olfactory bulb (OB). This study is the first to directly demonstrate that cholinergic effects on OPL require adult OB neurogenesis.

Keywords: olfactory bulb, adult neurogenesis, acetylcholine, olfactory perceptual learning, olfactory discrimination

Suggested Citation

Schilit Nitenson, Arielle and Manzano-Nieves, Gabriela and Poeta, Devon Lynn and Bahar, Ryan and Rachofsky, Carolyn and Mandairon, Nathalie and Bath, Kevin G., Acetylcholine Regulates Olfactory Perceptual Learning Through Effects on Adult Neurogenesis (June 1, 2019). ISCIENCE-D-19-00504. Available at SSRN: https://ssrn.com/abstract=3397315 or http://dx.doi.org/10.2139/ssrn.3397315
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Arielle Schilit Nitenson

Brown University

Box 1860
Providence, RI 02912
United States

Gabriela Manzano-Nieves

Brown University

Box 1860
Providence, RI 02912
United States

Devon Lynn Poeta

Brown University

Box 1860
Providence, RI 02912
United States

Ryan Bahar

Brown University

Box 1860
Providence, RI 02912
United States

Carolyn Rachofsky

Brown University

Box 1860
Providence, RI 02912
United States

Nathalie Mandairon

Lyon Neuroscience Research Center ( email )

France

Kevin G. Bath (Contact Author)

Brown University - Department of Cognitive, Linguistic and Psychological Sciences ( email )

United States

Click here to go to Cell.com

Go to Cell.com

Paper statistics

Abstract Views
173
Downloads
8