Clinical Signs Associated with Earlier Diagnosis of Children with Autism Spectrum Disorder

38 Pages Posted: 15 Jun 2019 Last revised: 23 Sep 2019

See all articles by Nachum Sicherman

Nachum Sicherman

Columbia University; IZA Institute of Labor Economics

Jimmy Charité

Columbia University

Gil Eyal

Columbia University

Magdalena Janecka

Mount Sinai Health System - Icahn School of Medicine

George Loewenstein

Carnegie Mellon University - Department of Social and Decision Sciences

Kiely Law

Johns Hopkins School of Medicine

Paul Lipkin

Johns Hopkins School of Medicine

Alison Marvin

Johns Hopkins School of Medicine

Joseph D. Buxbaum

Icahn School of Medicine at Mount Sinai - Department of Psychiatry; Icahn School of Medicine at Mount Sinai - Department of Genetics and Genomic Sciences; Icahn School of Medicine at Mount Sinai - Icahn Institute for Genomics and Multiscale Biology; Icahn School of Medicine at Mount Sinai - Seaver Autism Center for Research and Treatment; James J. Peters Veterans Affairs Medical Center - Mental Health Care Center

Date Written: May 30, 2019

Abstract

The objective of this study is to gain new insights into the relationship between clinical signs and age at diagnosis utilizing a new, large, online survey of parents of children diagnosed with ASD. Using multiple statistical approaches, we find that clinical signs and symptoms that most strongly predict early diagnosis are not necessarily specific to autism, but rather those that initiate the process that eventually leads to an ASD diagnosis. Given the high correlations between symptoms, only a few symptoms are found to be important in predicting early diagnosis. Even though our data are drawn from parents’ retrospective accounts, we provide evidence that parental recall bias and/or hindsight bias did not play a significant role in shaping our results.

Keywords: Autism spectrum disorder; symptoms; clinical signs; early diagnosis; diagnosis age; regression trees

Suggested Citation

Sicherman, Nachum and Charité, Jimmy and Eyal, Gil and Janecka, Magdalena and Loewenstein, George F. and Law, Kiely and Lipkin, Paul and Marvin, Alison and Buxbaum, Joseph D., Clinical Signs Associated with Earlier Diagnosis of Children with Autism Spectrum Disorder (May 30, 2019). Available at SSRN: https://ssrn.com/abstract=3398420 or http://dx.doi.org/10.2139/ssrn.3398420

Nachum Sicherman (Contact Author)

Columbia University ( email )

3022 Broadway
New York, NY 10027
United States
212-854-4464 (Phone)
212-316-9355 (Fax)

IZA Institute of Labor Economics

P.O. Box 7240
Bonn, D-53072
Germany

Jimmy Charité

Columbia University ( email )

3022 Broadway
New York, NY 10027
United States

Gil Eyal

Columbia University ( email )

413 Fayerweather Hall
1180 Amsterdam Avenue
New York, NY 10027
United States

Magdalena Janecka

Mount Sinai Health System - Icahn School of Medicine

One Gustave L. Levy Place
New York, NY 10029-6574
United States

George F. Loewenstein

Carnegie Mellon University - Department of Social and Decision Sciences ( email )

Pittsburgh, PA 15213-3890
United States
412-268-8787 (Phone)
412-268-6938 (Fax)

Kiely Law

Johns Hopkins School of Medicine ( email )

MD

Paul Lipkin

Johns Hopkins School of Medicine ( email )

MD

Alison Marvin

Johns Hopkins School of Medicine ( email )

MD

Joseph D. Buxbaum

Icahn School of Medicine at Mount Sinai - Department of Psychiatry

New York, NY 10025
United States

Icahn School of Medicine at Mount Sinai - Department of Genetics and Genomic Sciences

1425 Madison Avenue
New York, NY 10029
United States

Icahn School of Medicine at Mount Sinai - Icahn Institute for Genomics and Multiscale Biology

1425 Madison Ave
New York, NY 10029
United States

Icahn School of Medicine at Mount Sinai - Seaver Autism Center for Research and Treatment

New York City, NY
United States

James J. Peters Veterans Affairs Medical Center - Mental Health Care Center

Bronx, NY
United States

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