Global Burden of Breast Cancer and Attributable Risk Factors in 195 Countries and Territories, from 1990 to 2017: Results from the Global Burden of Disease Study 2017
26 Pages Posted: 7 Jun 2019More...
Objective: Statistical data on the incidence, mortality, and burden of breast cancer and the relevant risk factors are valuable for policy-making. We aimed to estimate breast cancer incidence, deaths, and disability-adjusted life years (DALYs) by country, gender, age group, and socio-demographic status between 1990 and 2017.
Methods: We extracted breast cancer data from the 2017 Global Burden of Disease (GBD) study from 1990 through 2017 in 195 countries and territories. Data about the number of breast cancer incident cases, deaths, DALYs, and the age-standardized rates were collected and estimated annual percentage changes of age standardized incidence rate (ASIR) were calculated. We also estimated the risk factors attributable to breast cancer deaths and DALYs using the comparative risk assessment framework of the GBD study.
Results: In 2017, the global incidence of breast cancer increased to 1,960,681 cases (95% UI = 1,891,447-2,023,170) with an ASIR of 24.19/100,000 persons (95% UI = 23.34-24.86). The high social-development index (SDI) quintile included the highest number of breast cancer deaths cases (181,004, 95% UI=176,078-186,127). Between 2007 and 2017, the ASDR of breast cancer declined globally, especially in high SDI and high middle SDI countries. Global breast cancer-related DALYs were 17,708,600 (95% UI = 16,899,498-18,674,972) in 2017 with high middle SDI quintile as the highest contributor. Of breast cancer deaths and DALYs, alcohol use was the greatest constributor in most GBD regions and other constributors included high body mass index (BMI) and high fasting plasma glucose.
Conclusion: The increasing global breast cancer burden is mainly observed in lower SDI countries; in higher SDI countries, the breast cancer burden tends to be relieving. Therefore, steps against attributable risk factors should be taken to reduce breast cancer burden in lower SDI countries.
Funding Statement: This study was supported by National Natural Science Foundation of China (No. 81471670); the International Cooperative Project of Shaanxi province, China (No. 2016KW-008) and the Key research and development plan, Shaanxi Province, China (2017ZDXM-SF-066).
Declaration of Interests: The authors have declared no conflicts of interest.
Ethics Approval Statement: Not Required.
Keywords: Breast cancer, Global cancer burden, Disability adjusted life years, Alcohol use, Incidence
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