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Global Burden of Breast Cancer and Attributable Risk Factors in 195 Countries and Territories, from 1990 to 2017: Results from the Global Burden of Disease Study 2017

26 Pages Posted: 7 Jun 2019

See all articles by Na Li

Na Li

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Yujiao Deng

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Linghui Zhou

Xi'an Jiaotong University (XJTU) - Department of Oncology

Tian Tian

Xi'an Jiaotong University (XJTU) - Department of Oncology

Si Yang

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

Ying Wu

Xi'an Jiaotong University (XJTU) - Department of Oncology

Yi Zheng

Zhejiang University - Department of Breast Surgery

Zhen Zhai

Xi'an Jiaotong University (XJTU) - Department of Oncology

Qian Hao

Xi'an Jiaotong University (XJTU) - Department of Oncology

Dingli Song

Xi'an Jiaotong University (XJTU) - Department of Oncology

Dai Zhang

Xi'an Jiaotong University (XJTU) - Department of Oncology

Huafeng Kang

Xi'an Jiaotong University (XJTU) - Department of Oncology

Zhi-Jun Dai

Zhejiang University - Department of Breast Surgery; Xi'an Jiaotong University (XJTU) - Department of Oncology

More...

Abstract

Objective: Statistical data on the incidence, mortality, and burden of breast cancer and the relevant risk factors are valuable for policy-making. We aimed to estimate breast cancer incidence, deaths, and disability-adjusted life years (DALYs) by country, gender, age group, and socio-demographic status between 1990 and 2017.

Methods: We extracted breast cancer data from the 2017 Global Burden of Disease (GBD) study from 1990 through 2017 in 195 countries and territories. Data about the number of breast cancer incident cases, deaths, DALYs, and the age-standardized rates were collected and estimated annual percentage changes of age standardized incidence rate (ASIR) were calculated. We also estimated the risk factors attributable to breast cancer deaths and DALYs using the comparative risk assessment framework of the GBD study.

Results: In 2017, the global incidence of breast cancer increased to 1,960,681 cases (95% UI = 1,891,447-2,023,170) with an ASIR of 24.19/100,000 persons (95% UI = 23.34-24.86). The high social-development index (SDI) quintile included the highest number of breast cancer deaths cases (181,004, 95% UI=176,078-186,127). Between 2007 and 2017, the ASDR of breast cancer declined globally, especially in high SDI and high middle SDI countries. Global breast cancer-related DALYs were 17,708,600 (95% UI = 16,899,498-18,674,972) in 2017 with high middle SDI quintile as the highest contributor. Of breast cancer deaths and DALYs, alcohol use was the greatest constributor in most GBD regions and other constributors included high body mass index (BMI) and high fasting plasma glucose.

Conclusion: The increasing global breast cancer burden is mainly observed in lower SDI countries; in higher SDI countries, the breast cancer burden tends to be relieving. Therefore, steps against attributable risk factors should be taken to reduce breast cancer burden in lower SDI countries.

Funding Statement: This study was supported by National Natural Science Foundation of China (No. 81471670); the International Cooperative Project of Shaanxi province, China (No. 2016KW-008) and the Key research and development plan, Shaanxi Province, China (2017ZDXM-SF-066).

Declaration of Interests: The authors have declared no conflicts of interest.

Ethics Approval Statement: Not Required.

Keywords: Breast cancer, Global cancer burden, Disability adjusted life years, Alcohol use, Incidence

Suggested Citation

Li, Na and Deng, Yujiao and Zhou, Linghui and Tian, Tian and Yang, Si and Wu, Ying and Zheng, Yi and Zhai, Zhen and Hao, Qian and Song, Dingli and Zhang, Dai and Kang, Huafeng and Dai, Zhi-Jun, Global Burden of Breast Cancer and Attributable Risk Factors in 195 Countries and Territories, from 1990 to 2017: Results from the Global Burden of Disease Study 2017 (June 3, 2019). Available at SSRN: https://ssrn.com/abstract=3398545

Na Li

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Yujiao Deng

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Linghui Zhou

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Tian Tian

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Si Yang

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Ying Wu

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Yi Zheng

Zhejiang University - Department of Breast Surgery

Hangzhou
China

Zhen Zhai

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Qian Hao

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Dingli Song

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'An
China

Dai Zhang

Xi'an Jiaotong University (XJTU) - Department of Oncology

Xi'an
China

Huafeng Kang

Xi'an Jiaotong University (XJTU) - Department of Oncology ( email )

Xi'an
China

Zhi-Jun Dai (Contact Author)

Zhejiang University - Department of Breast Surgery ( email )

Hangzhou
China

Xi'an Jiaotong University (XJTU) - Department of Oncology ( email )

Xi'an
China

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