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Mechanical-Chemical Coupling in Temporomandibular Joint Disc

29 Pages Posted: 11 Jun 2019 First Look: Accepted

See all articles by Rodney Marcelo do Nascimento

Rodney Marcelo do Nascimento

University of São Paulo (USP) - Institute of Physics; University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Adrien Baldit

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Ninel Kokanyan

University of Paris-Saclay - Laboratoire Matériaux Optiques, Photonique et Systèmes (LMOPS)

Lara Kristin Tappert

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Paul Lipinski

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Antônio Carlos Hernandes

University of São Paulo (USP) - Institute of Physics

Rachid Rahouadj

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Abstract

This paper reports an experimental investigation based on vibrational spectroscopy of biological materials by a new custom-made device allowing simultaneously applying tensile load with changes within a controlled chemical environment. The response of the molecular structures of Temporomandibular Joint (TMJ) discs under simulated daily mechanical stimulations was characterized by stress-strain analysis and Raman spectra. The results show that changes in the biochemical environment around tissue (associated to common disorders) led to significant modifications to its mechanical properties. The molecular response to stress was then fully characterized by a combination of molecular mapping followed by statistical analysis via Principal Component Analysis resulting in the identification of the phenylalanine-aromatic amino acids as a significant and major mechanical-chemical effector of TMJ discs. The coupled tensile machine and vibrational spectroscopy approach enabling in-situ molecular studies proves to be a powerful technique for biological material characterization and tissue engineering.

Keywords: biological material, mechanical stressing, chemical environment, molecular mapping, temporomandibular disc, tissue engineering

Suggested Citation

Nascimento, Rodney Marcelo do and Baldit, Adrien and Kokanyan, Ninel and Tappert, Lara Kristin and Lipinski, Paul and Hernandes, Antônio Carlos and Rahouadj, Rachid, Mechanical-Chemical Coupling in Temporomandibular Joint Disc (June 9, 2019). Available at SSRN: https://ssrn.com/abstract=3401355 or http://dx.doi.org/10.2139/ssrn.3401355

Rodney Marcelo do Nascimento (Contact Author)

University of São Paulo (USP) - Institute of Physics ( email )

Brazil

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant ( email )

Lorraine
France

Adrien Baldit

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Lorraine
France

Ninel Kokanyan

University of Paris-Saclay - Laboratoire Matériaux Optiques, Photonique et Systèmes (LMOPS)

2 rue E. Belin
Metz, 57070
France

Lara Kristin Tappert

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Lorraine
France

Paul Lipinski

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Lorraine
France

Antônio Carlos Hernandes

University of São Paulo (USP) - Institute of Physics

Brazil

Rachid Rahouadj

University of Lorraine - Departement Mécanique des Matériaux, des Structures et du Vivant

Lorraine
France

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