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­­Age-Dependent Sexual Dimorphism in the Adult Human Gut Microbiota

49 Pages Posted: 13 Jun 2019 Sneak Peek Status: Review Complete

See all articles by Xiuying Zhang

Xiuying Zhang

Peking University - Department of Endocrinology and Metabolism

Huanzi Zhong

Beijing Genomics Institute (BGI)

Yufeng Li

Beijing Pinggu Hospital

Zhun Shi

Beijing Genomics Institute (BGI)

Zhe Zhang

Beijing Genomics Institute (BGI)

Xianghai Zhou

Peking University - Department of Endocrinology and Metabolism

Huahui Ren

Beijing Genomics Institute (BGI)

Shanmei Tang

Beijing Genomics Institute (BGI)

Xueyao Han

Peking University - Department of Endocrinology and Metabolism

Yuxiang Lin

Beijing Genomics Institute (BGI)

Dan Wang

Beijing Genomics Institute (BGI)

Fangming Yang

Beijing Genomics Institute (BGI)

Chao Fang

Beijing Genomics Institute (BGI)

Zuodi Fu

Capital Medical University

Lianying Wang

Capital Medical University

Shida Zhu

Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI) - China National Genebank

Yong Hou

Beijing Genomics Institute (BGI)

Xun Xu

Beijing Genomics Institute (BGI)

Huanming Yang

Beijing Genomics Institute (BGI)

Jian Wang

Beijing Genomics Institute (BGI)

Karsten Kristiansen

Beijing Genomics Institute (BGI)

Junhua Li

Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI) - China National Genebank

Linong Ji

Peking University - Department of Endocrinology and Metabolism

More...

Abstract

Numerous studies have established the importance of the gut microbiota in human health. However, large-scale studies on the impact of sex and age on the gut microbiota are limited. Here we uncover unexpected age-related sex differences in the adult gut microbial composition and functionality in two large cohorts from China and the Netherlands. Compared to men, women harbor a more diverse and surprisingly stable microbiota with no robust changes associated with menopause. By contrast, men exhibit a more variable gut microbiota across broad age ranges, exhibiting strong correlations to age, testosterone levels, and multiple clinical parameters. Sex-associated differences between the gut microbiota are strongly correlated with lifestyle including smoking and alcohol intake. Interestingly, the marked sex-dependent differences between the gut microbiota in younger individuals diminish by age. Our findings provide a foundation for future studies on sex- and age-dependent effects on the impact of the gut microbiota on human health.

Keywords: Age, sex differences, the human adult gut microbiota

Suggested Citation

Zhang, Xiuying and Zhong, Huanzi and Li, Yufeng and Shi, Zhun and Zhang, Zhe and Zhou, Xianghai and Ren, Huahui and Tang, Shanmei and Han, Xueyao and Lin, Yuxiang and Wang, Dan and Yang, Fangming and Fang, Chao and Fu, Zuodi and Wang, Lianying and Zhu, Shida and Hou, Yong and Xu, Xun and Yang, Huanming and Wang, Jian and Kristiansen, Karsten and Li, Junhua and Ji, Linong, ­­Age-Dependent Sexual Dimorphism in the Adult Human Gut Microbiota (June 13, 2019). CELL-D-19-01527. Available at SSRN: https://ssrn.com/abstract=3403335 or http://dx.doi.org/10.2139/ssrn.3403335
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Xiuying Zhang

Peking University - Department of Endocrinology and Metabolism

Beijing
China

Huanzi Zhong (Contact Author)

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Yufeng Li

Beijing Pinggu Hospital

Beijing
China

Zhun Shi

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Zhe Zhang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Xianghai Zhou

Peking University - Department of Endocrinology and Metabolism

Beijing
China

Huahui Ren

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Shanmei Tang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Xueyao Han

Peking University - Department of Endocrinology and Metabolism ( email )

Beijing
China

Yuxiang Lin

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Dan Wang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Fangming Yang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Chao Fang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Zuodi Fu

Capital Medical University

China

Lianying Wang

Capital Medical University

China

Shida Zhu

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Beijing Genomics Institute (BGI) - China National Genebank

Shenzhen
China

Yong Hou

Beijing Genomics Institute (BGI) ( email )

Shenzhen, Guangdong 518083
China

Xun Xu

Beijing Genomics Institute (BGI) ( email )

Shenzhen, Guangdong 518083
China

Huanming Yang

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Jian Wang

Beijing Genomics Institute (BGI) ( email )

Shenzhen, Guangdong 518083
China

Karsten Kristiansen

Beijing Genomics Institute (BGI) ( email )

Shenzhen, Guangdong 518083
China

Junhua Li

Beijing Genomics Institute (BGI)

Shenzhen, Guangdong 518083
China

Beijing Genomics Institute (BGI) - China National Genebank

Shenzhen
China

Linong Ji

Peking University - Department of Endocrinology and Metabolism ( email )

Beijing
China

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