Aflatoxins Biosynthesis, Toxicity and Intervention Strategies: A Review

M. Iqbal, M. Abbas, M. Adil, A. Nazir and I. Ahmad. Aflatoxins biosynthesis, toxicity and intervention strategies: A review. Chemistry International 5(3), 168-191, 2019

24 Pages Posted: 11 May 2020

See all articles by Munawar Iqbal

Munawar Iqbal

University of Lahore (UOL)

Mazhar Abbas

University of Veterinary and Animal Sciences

Muhammad Adil

University of Veterinary and Animal Sciences, Lahore

Arif Nazir

The University of Lahore

Iftikhar Ahmad

Göteborg University, SE-41296, Göteborg, Sweden

Date Written: 2018

Abstract

Aflatoxins (AFTs) are toxic products of fungal metabolism, associated with serious health consequences and substantial economic losses to agriculture, livestock and poultry sectors, particularly in the developing countries. This review outlines the current information on AFTs in terms of historical background, classification, relative occurrence and co-existence with other mycotoxins in various food commodities. The phenomenon of aflatoxin (AFT) biosynthesis has been elucidated with reference to molecular basis, genetic regulation and factors affecting the AFT production. Moreover, the in vivo disposition kinetics, toxicological action and toxico-pathological consequences of AFTs have also been highlighted. Currently employed strategies for the detection and detoxification of AFTs, biomarkers of exposure assessment, potential economic impact and regulatory considerations regarding the AFTs have been emphasized.

Keywords: Aflatoxin, Biosynthesis, Toxicity, Control Measures

Suggested Citation

Iqbal, Munawar and Abbas, Mazhar and Adil, Muhammad and Nazir, Arif and Ahmad, Iftikhar, Aflatoxins Biosynthesis, Toxicity and Intervention Strategies: A Review (2018). M. Iqbal, M. Abbas, M. Adil, A. Nazir and I. Ahmad. Aflatoxins biosynthesis, toxicity and intervention strategies: A review. Chemistry International 5(3), 168-191, 2019, Available at SSRN: https://ssrn.com/abstract=3407341 or http://dx.doi.org/10.2139/ssrn.3407341

Munawar Iqbal (Contact Author)

University of Lahore (UOL)

KM Defence Road Campus
54000
Lahore, Punjab 54000
Pakistan

Mazhar Abbas

University of Veterinary and Animal Sciences

Shaykh Abdul Qadir Jilani Rd
Lahore, 54000
Pakistan

Muhammad Adil

University of Veterinary and Animal Sciences, Lahore ( email )

Arif Nazir

The University of Lahore ( email )

1 - KM Defence Road off Raiwind Road
Lahore, PA Punjab 54000
Pakistan

Iftikhar Ahmad

Göteborg University, SE-41296, Göteborg, Sweden ( email )

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