Suppressive Effects of Neonatal Bisphenol A on the Neuroendocrine System
Ahmed, R.G., Walaa G.H., Asmaa F.S., 2018.Suppressive Effects of Neonatal Bisphenol a on the Neuroendocrine System. Toxicology and Industrial Health Journal 34(6), 397-407. Doi: 10.1177/0748233718757082.
Posted: 2 Jul 2019
Date Written: January 10, 2018
The aim of this study was to assess the effects of neonatal bisphenol A (BPA) administration on neuroendocrine features (the thyroid-brain axis). 20 or 40 µg/kg of BPA was orally administered to juvenile male albino rats (Rattus norvegicus) from postnatal days (PNDs) 15 to 30. Both doses resulted in lower serum thyroxine (T4), triiodothyronine (T3) and growth hormone (GH) levels, and higher thyrotropin (TSH) level than the control levels at PND 30. In the neonatal cerebellum and cerebrum, vacuolation, pyknosis, oedema, degenerative changes, and reductions in the size and number of the cells were observed in both treated groups. Alternatively, elevations in oxidative markers [lipid peroxidation (LPO), nitric oxide (NO), and hydrogen peroxide (H2O2)] due to both doses were recorded at PND 30, along with decreased activities of antioxidant markers [ascorbic acid (AA), total thiol (t-SH), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and catalase (CAT)] with respect to control levels. Thus, the BPA-induced hypothyroid state may disturb the neonatal thyroid-brain axis via production of free radicals, and this could damage the plasma membrane and cellular components, delaying cerebrum and cerebellum development.
Keywords: Bisphenol A, Thyroid hormones, Cerebellum, Cerebrum, Antioxidants, Prooxidants.
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