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The Genomic Impact of European Colonization of the Americas

51 Pages Posted: 12 Jul 2019 Sneak Peek Status: Review Complete

See all articles by Linda Ongaro

Linda Ongaro

University of Tartu - Estonian Biocentre

Marilia O. Scliar

University of São Paulo (USP) - Center for Research on the Human Genome and Stem Cells - Centro de Pesquisas sobre o Genoma Humano e Células Tronco

J. Rodrigo Flores

University of Tartu - Estonian Biocentre

Alessandro Raveane

University of Pavia - Department of Biology and Biotechnology

Davide Marnetto

University of Tartu - Estonian Biocentre

Stefania Sarno

University of Bologna

Guido A. Gnecchi-Ruscone

University of Bologna

Marta E. Alarcon-Riquelme

University of Granada

Etienne Patin

Institut Pasteur

Pongsakorn Wangkumhang

University College London

Garrett Hellenthal

University College London

Miguel Gonzalez-Santos

University of Oxford - Department of Zoology

Roy J. King

Stanford University - Department of Psychiatry and Behavioral Sciences

Anastasia Kouvatsi

Aristotle University of Thessaloniki

Oleg Balanovsky

Research Centre of Medical Genetics

Elena Balanovska

Research Centre of Medical Genetics

Lubov Atramentova

V.N. Karazin Kharkiv National University - Department of Genetics and Cytology

Shahlo Turdikulova

Uzbekistan Academy of Sciences

Sarabjit Mastana

Loughborough University - Human Genomics Lab., Centre for Global Health and Human Development

Damir Marjanovic

International Burch University (IBU)

Lejla Kovacevic

Institute for Genetic Engineering and Biotechnology

Andreja Leskovac

University of Belgrade

Maria F. Lima-Costa

Oswaldo Cruz Foundation (FIOCRUZ)

Alexandre C. Pereira

University of São Paulo (USP)

Mauricio L. Barreto

Federal University of Bahia (UFBA) - Instituto Saúde Coletiva

Bernardo L. Horta

Federal University of Pelotas (UFPel) - Postgraduate Program in Epidemiology

Nédio Mabunda

Instituto Nacional de Saude

Celia A. May

University of Leicester

Andrés Moreno-Estrada

Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN)

Alessandro Achilli

University of Pavia - Department of Biology and Biotechnology

Anna Olivieri

University of Pavia - Department of Biology and Biotechnology

Ornella Semino

University of Pavia - Department of Biology and Biotechnology

Kristiina Tambets

University of Tartu - Estonian Biocentre

Toomas Kivisild

University of Tartu - Estonian Biocentre; KU Leuven

Donata Luiselli

University of Bologna

Antonio Torroni

University of Pavia - Department of Biology and Biotechnology

Cristian Capelli

University of Oxford - Department of Zoology

Eduardo Tarazona-Santos

Federal University of Minas Gerais (UFMG)

Mait Metspalu

University of Tartu - Estonian Biocentre

Luca Pagani

University of Tartu - Estonian Biocentre; University of Padova

Francesco Montinaro

University of Tartu - Estonian Biocentre

More...

Abstract

The human genetic diversity of the Americas has been shaped by several events of gene flow that have continued since the Colonial Era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here we compiled a genome-wide dataset of ~12,000 individuals from twelve American countries and ~6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected i) the genetic structure, ii) the admixture profile, iii) the demographic history and iv) sex-biased gene-flow dynamics, of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East and to specific regions of Africa.

Keywords: Admixture history of the Americas, Atlantic Slave Trade, European colonization, Sex-biased admixture, Demographic history

Suggested Citation

Ongaro, Linda and Scliar, Marilia O. and Flores, J. Rodrigo and Raveane, Alessandro and Marnetto, Davide and Sarno, Stefania and Gnecchi-Ruscone, Guido A. and Alarcon-Riquelme, Marta E. and Patin, Etienne and Wangkumhang, Pongsakorn and Hellenthal, Garrett and Gonzalez-Santos, Miguel and King, Roy J. and Kouvatsi, Anastasia and Balanovsky, Oleg and Balanovska, Elena and Atramentova, Lubov and Turdikulova, Shahlo and Mastana, Sarabjit and Marjanovic, Damir and Kovacevic, Lejla and Leskovac, Andreja and Lima-Costa, Maria F. and Pereira, Alexandre C. and Barreto, Mauricio L. and Horta, Bernardo L. and Mabunda, Nédio and May, Celia A. and Moreno-Estrada, Andrés and Achilli, Alessandro and Olivieri, Anna and Semino, Ornella and Tambets, Kristiina and Kivisild, Toomas and Luiselli, Donata and Torroni, Antonio and Capelli, Cristian and Tarazona-Santos, Eduardo and Metspalu, Mait and Pagani, Luca and Montinaro, Francesco, The Genomic Impact of European Colonization of the Americas (July 10, 2019). CURRENT-BIOLOGY-D-19-01088. Available at SSRN: https://ssrn.com/abstract=3417946 or http://dx.doi.org/10.2139/ssrn.3417946
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Linda Ongaro

University of Tartu - Estonian Biocentre ( email )

Tartu
Estonia

Marilia O. Scliar

University of São Paulo (USP) - Center for Research on the Human Genome and Stem Cells - Centro de Pesquisas sobre o Genoma Humano e Células Tronco

São Paulo
Brazil

J. Rodrigo Flores

University of Tartu - Estonian Biocentre

Tartu
Estonia

Alessandro Raveane

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Davide Marnetto

University of Tartu - Estonian Biocentre

Tartu
Estonia

Stefania Sarno

University of Bologna

Piazza Scaravilli 2
Bologna, 40100
Italy

Guido A. Gnecchi-Ruscone

University of Bologna

Piazza Scaravilli 2
Bologna, 40100
Italy

Marta E. Alarcon-Riquelme

University of Granada

C/Rector López Argueta S/N
Granada, Granada 18071
Spain

Etienne Patin

Institut Pasteur

75724 Paris CEDEX 15
France

Pongsakorn Wangkumhang

University College London

Gower Street
London, WC1E 6BT
United Kingdom

Garrett Hellenthal

University College London

Gower Street
London, WC1E 6BT
United Kingdom

Miguel Gonzalez-Santos

University of Oxford - Department of Zoology

New Radcliffe House
Radcliffe Observatory Quarter
Oxford, OX13 5QL
United Kingdom

Roy J. King

Stanford University - Department of Psychiatry and Behavioral Sciences

401 Quarry Road
Stanford, CA 94304-5718
United States

Anastasia Kouvatsi

Aristotle University of Thessaloniki

Thessaloniki
Greece

Oleg Balanovsky

Research Centre of Medical Genetics

Russia

Elena Balanovska

Research Centre of Medical Genetics

Russia

Lubov Atramentova

V.N. Karazin Kharkiv National University - Department of Genetics and Cytology

Kharkiv
Ukraine

Shahlo Turdikulova

Uzbekistan Academy of Sciences

25 F. Khodjaez Street
Tashkent
Uzbekistan

Sarabjit Mastana

Loughborough University - Human Genomics Lab., Centre for Global Health and Human Development ( email )

Ashby Road
Nottingham NG1 4BU
Great Britain

Damir Marjanovic

International Burch University (IBU)

Sarajevo
Bosnia and Herzegovina

Lejla Kovacevic

Institute for Genetic Engineering and Biotechnology

Bosnia and Herzegovina

Andreja Leskovac

University of Belgrade

Studentski trg 1
Belgrade, 11000
Serbia

Maria F. Lima-Costa

Oswaldo Cruz Foundation (FIOCRUZ)

Rio de Janeiro
Brazil

Alexandre C. Pereira

University of São Paulo (USP)

Rua Luciano Gualberto, 315
São Paulo, São Paulo 14800-901
Brazil

Mauricio L. Barreto

Federal University of Bahia (UFBA) - Instituto Saúde Coletiva

Rua Basílio da Gama, s/n
Salvador
Portugal

Bernardo L. Horta

Federal University of Pelotas (UFPel) - Postgraduate Program in Epidemiology

Brazil

Nédio Mabunda

Instituto Nacional de Saude

Avenida Eduardo Mondlane, No. 1008
Maputo
Mozambique

Celia A. May

University of Leicester

University Road
Leicester, LE1 7RH
United Kingdom

Andrés Moreno-Estrada

Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN)

07360 Mexico, D.F.
Mexico

Alessandro Achilli

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Anna Olivieri

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Ornella Semino

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Kristiina Tambets

University of Tartu - Estonian Biocentre

Tartu
Estonia

Toomas Kivisild

University of Tartu - Estonian Biocentre

Tartu
Estonia

KU Leuven

Oude Markt 13
Leuven, Vlaams-Brabant 3000
Belgium

Donata Luiselli

University of Bologna

Piazza Scaravilli 2
Bologna, 40100
Italy

Antonio Torroni

University of Pavia - Department of Biology and Biotechnology

Corso Str. Nuova, 65, 27100
Pavia
Italy

Cristian Capelli

University of Oxford - Department of Zoology

New Radcliffe House
Radcliffe Observatory Quarter
Oxford, OX13 5QL
United Kingdom

Eduardo Tarazona-Santos

Federal University of Minas Gerais (UFMG)

Av. Antonio Carlos, 6627
Belo Horizonte, Minas Gerais 31270-901
Brazil

Mait Metspalu

University of Tartu - Estonian Biocentre

Tartu
Estonia

Luca Pagani

University of Tartu - Estonian Biocentre

Tartu
Estonia

University of Padova

Via 8 Febbraio
Padova, 2-35122
Italy

Francesco Montinaro (Contact Author)

University of Tartu - Estonian Biocentre

Tartu
Estonia

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