Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.
U-Shaped Associations between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study
Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases; Shanghai Jiao Tong University (SJTU) - Shanghai Institute of Endocrine and Metabolic Diseases; Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases
Shandong First Medical University - Science and Technology Innovation Center; Shandong First Medical University - Department of Endocrinology and Metabolism; Shandong Academy of Clinical Medicine - Institute of Endocrinology; Shandong Clinical Medical Center of Endocrinology and Metabolism
Background: Iodine is important in both thyroid function and human metabolism. Studies have explored the effect of iodine on metabolic disorders through thyroid function. This study aimed to investigate the relationship between iodine status and metabolic disorders.
Methods: Data were obtained from the TIDE program, including 51795 subjects aged ≥18 years. The prevalence of metabolic disorders and its related components were calculated based on the level of urinary iodine concentrations (UICs) using the chi-square method. To further explore whether prevalence was associated with UIC, quadratic and UIC-stratified logistic regression models were used.
Findings: The prevalence of metabolic disorders presented as a U-shaped curve as the UICs change with a lower prevalence of 76% at a UIC of 300-499 µg/L. After adjusting for confounding factors, UIC of 300-499 µg/L was found to be a protective factor for metabolic disorders [OR=0·857, 95%CI (0·796-0·922)] and hypertension. A UIC of 300-799 µg/L was found to be protective against the occurrence of metabolic syndrome (MetS), impaired fasting glucose (IFG). 500-799 µg/L was protective against the occurrence of prediabetes, UIC ≥ µg/L was found to be protective against the occurrence of dyslipidemia. Furthermore, a UIC of <100 µg/L was a risk factor for hypertension.
Interpretation: The association between UICs in adults and metabolic disorders and its components is U-shaped. The beneficial effect of UIC on metabolic disorders disappears in cases of iodine deficiency (<100 µg/L) or excess (>500 µg/L).
Funding Statement: This work is supported by the Research Fund for Public Welfare from National Health and Family Planning Commission of China (Grant No. 201402005).
Declaration of Interests: All authors declare no competing interests.
Ethical Approval Statement: The ethics committee approved the study protocol.
Jin, Mingyue and Zhang, Zhuo and Li, Yongze and Teng, Di and Shi, Xiaoguang and Ba, Jianming and Chen, Bing and Du, Jianling and He, Lanjie and Lai, Xiaoyang and Teng, Xiaochun and Li, Yanbo and Chi, Haiyi and Liao, Eryuan and Liu, Chao and Liu, Libin and Qin, Guijun and Qin, Yingfen and Quan, Huibiao and Shi, Bingyin and Sun, Hui and Tang, Xulei and Tong, Nanwei and Wang, Guixia and Zhang, Jin-an and Wang, Youmin and Xue, Yuanming and Yan, Li and Yang, Jing and Yang, Lihui and Yao, Yongli and Ye, Zhen and Zhang, Qiao and Zhang, Lihui and Zhu, Jun and Zhu, Mei and Ning, Guang and Mu, Yiming and Zhao, Jiajun and Teng, Weiping and Shan, Zhongyan, U-Shaped Associations between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study (July 19, 2019). Available at SSRN: https://ssrn.com/abstract=3422992 or http://dx.doi.org/10.2139/ssrn.3422992
Subscribe to this free journal for more curated articles on this topic
FOLLOWERS
241
PAPERS
10,796
Feedback
Feedback to SSRN
If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday.
Download This Paper