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Four-Dimensional Bioprinting: Current Developments and Applications in Bone Tissue Engineering

73 Pages Posted: 23 Jul 2019 Publication Status: Accepted

See all articles by Zhuqing Wan

Zhuqing Wan

Peking University - Department of Prosthodontics; Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology; Peking University - National clinical Research Center for Oral Diseases; Peking University - Beijing Key Laboratory of Digital Stomatology

Ping Zhang

Peking University - Department of Prosthodontics; Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology; Peking University - National clinical Research Center for Oral Diseases; Peking University - Beijing Key Laboratory of Digital Stomatology

Yunsong Liu

Peking University - Department of Prosthodontics; Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology; Peking University - National clinical Research Center for Oral Diseases; Peking University - Beijing Key Laboratory of Digital Stomatology

Longwei Lv

Peking University - Department of Prosthodontics; Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology; Peking University - National clinical Research Center for Oral Diseases; Peking University - Beijing Key Laboratory of Digital Stomatology

Yongsheng Zhou

Peking University - Department of Prosthodontics; Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology; Peking University - National clinical Research Center for Oral Diseases; Peking University - Beijing Key Laboratory of Digital Stomatology

Abstract

Four-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as the fourth dimension, is widely proposed as the next-generation of tissue engineering technology as it presents the possibility of constructing complex, functional structures. 4D bioprinting can be used to fabricate dynamic 3D patterned biological architectures that change their shapes or functions under various stimuli by employing stimuli-responsive materials or novel 3D bioprinting strategies, providing unprecedented potential for bone tissue engineering. The shape memory properties of printed structures cater to the need for personal bone defect repair and biomimetic microenvironments that promote the osteogenic differentiation of stem cells. In this review, we introduce the application of different stimuli-responsive biomaterials in tissue engineering and a series of novel 4D bioprinting strategies based on functional transformation of printed structures through the establishment of biomimetic constructs. Furthermore, we discuss the application of 4D bioprinting in bone tissue engineering, as well as future challenges and perspectives.

Keywords: 3D bioprinting, 4D bioprinting, tissue engineering, shape memory polymers, shape memory hydrogels, bone regeneration

Suggested Citation

Wan, Zhuqing and Zhang, Ping and Liu, Yunsong and Lv, Longwei and Zhou, Yongsheng, Four-Dimensional Bioprinting: Current Developments and Applications in Bone Tissue Engineering (2019). Available at SSRN: https://ssrn.com/abstract=3423498 or http://dx.doi.org/10.2139/ssrn.3423498

Zhuqing Wan (Contact Author)

Peking University - Department of Prosthodontics

China

Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology

China

Peking University - National clinical Research Center for Oral Diseases

China

Peking University - Beijing Key Laboratory of Digital Stomatology

China

Ping Zhang

Peking University - Department of Prosthodontics

China

Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology

China

Peking University - National clinical Research Center for Oral Diseases

China

Peking University - Beijing Key Laboratory of Digital Stomatology

China

Yunsong Liu

Peking University - Department of Prosthodontics

China

Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology

China

Peking University - National clinical Research Center for Oral Diseases

China

Peking University - Beijing Key Laboratory of Digital Stomatology

China

Longwei Lv

Peking University - Department of Prosthodontics ( email )

China

Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology ( email )

China

Peking University - National clinical Research Center for Oral Diseases ( email )

China

Peking University - Beijing Key Laboratory of Digital Stomatology ( email )

China

Yongsheng Zhou

Peking University - Department of Prosthodontics ( email )

China

Peking University - National Engineering Laboratory for Digital and Material Technology of Stomatology ( email )

China

Peking University - National clinical Research Center for Oral Diseases ( email )

China

Peking University - Beijing Key Laboratory of Digital Stomatology ( email )

China

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