High-Throughput Preparation of Antibacterial Polymers from Natural Product Derivatives via the Hantzsch Reaction
61 Pages Posted: 25 Jul 2019 Sneak Peek Status: Review CompleteMore...
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods lead to the identification of a new antibacterial polymer. Mechanistic studies revealed the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering new functional polymers for possible practical applications. It also provides insights to further developing functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science.
Suggested Citation: Suggested Citation