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Predictors of New Onsets of Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Fibromyalgia: The Lifelines Study

24 Pages Posted: 31 Jul 2019

See all articles by Rei Monden

Rei Monden

University of Groningen

Judith G.M. Rosmalen

University of Groningen

Klaas J. Wardenaar

University of Groningen

Francis Creed

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology; University of Manchester - Division of Psychology and Mental Health

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Abstract

Background: It is unclear whether the functional somatic syndromes share a common etiology or have distinct syndrome-specific mechanisms. This prospective population-based study assessed whether the same variables predict new onsets of self-reported Irritable bowel syndrome (IBS), Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM).

Methods: The study included adults participating in the Dutch Lifelines population-based study who reported the presence/absence of IBS, CFS or FM at baseline and follow-up (N=152,180). They were screened at baseline for physical and psychological disorders, socio-demographic, psycho-social and behavioral variables. At follow-up (mean 2.4 years) we identified new onsets of each syndrome by self-report. We performed separate analyses for the three syndromes, including only those participants who, at baseline, were free of the relevant syndrome or its key symptom. LASSO logistic regressions were applied to identify which of the 102 baseline variables predicted new onsets of each syndrome.

Findings: The numbers of new onsets were 1,595 (1.2%), 296 (0.2%) and 692 (0.5%) for IBS, CFS, and FM respectively. LASSO logistic regression selected 26, 7 and 19 predictors for IBS, CFS and FM respectively. Four predictors were shared by all three syndromes: somatic symptoms, disturbed sleep, recent chronic illness and negative health perception. Female sex, allergies, gastrointestinal disorders, high BMI and low alcohol consumption predicted both IBS and FM; recent stress predicted both IBS and CFS but 28 predictors were specific to a single syndrome. CFS was more distinct from IBS and FM, which predicted each other.

Interpretation: Syndrome-specific predictors were more common than shared ones. Such specific predictors might form a better starting point to unravel the heterogeneous etiologies of these syndromes than the current approach based on symptom patterns. The close relationship between IBS and FM is striking and the shared role of allergies, gastrointestinal and other medical disorders and medications needs further investigation.

Funding Statement: The authors state: "None."

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: Approved by the Medical Ethical Committee of the University Medical Center Groningen.

Keywords: Irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, epidemiology, risk factors

Suggested Citation

Monden, Rei and Rosmalen, Judith G.M. and Wardenaar, Klaas J. and Creed, Francis, Predictors of New Onsets of Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Fibromyalgia: The Lifelines Study (July 26, 2019). Available at SSRN: https://ssrn.com/abstract=3427300

Rei Monden

University of Groningen

P.O. Box 800
9700 AH Groningen, Groningen 9700 AV
Netherlands

Judith G.M. Rosmalen

University of Groningen

P.O. Box 800
9700 AH Groningen, Groningen 9700 AV
Netherlands

Klaas J. Wardenaar

University of Groningen

P.O. Box 800
9700 AH Groningen, Groningen 9700 AV
Netherlands

Francis Creed (Contact Author)

University of Manchester, Faculty of Biology, Medicine and Health, School of Biological Sciences, Department of Neuroscience and Experimental Psychology ( email )

Oxford Road
Manchester, M13 9PL
United Kingdom

University of Manchester - Division of Psychology and Mental Health ( email )

Manchester
United Kingdom

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