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Scattering-Induced Absorption Acts as a Cancer Treatment Monitor

20 Pages Posted: 30 Jul 2019 Sneak Peek Status: Review Complete

See all articles by Aviad Katiyi

Aviad Katiyi

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering; Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology; Ben-Gurion University of the Negev - Center for Quantum Information Science and Technology

Jonathan Zorea

Ben-Gurion University of the Negev - The Shraga Segal Department of Microbiology, Immunology and Genetics

Aviran Halstuch

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering; Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology

Moshe Elkabets

Ben-Gurion University of the Negev - The Shraga Segal Department of Microbiology, Immunology and Genetics

Alina Karabchevsky

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering; Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology; Ben-Gurion University of the Negev - Center for Quantum Information Science and Technology

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Abstract

Uncontrolled growth of ovarian cancer cells is the fifth leading cause of female cancer deaths. Here, we describe the role of scattering-induced absorption in monitoring the cancer treatment efficiency in real-time. We measure the optical interaction between the evanescent fields of microfiber and ovarian cancer inter-cellular medium at different treatment stages. By introducing the roughness of silica glass, we demonstrate that the treatment of tumor cells with GDC0032, a beta-sparing PI3K, induces both cells growth arrest and alter the spectral lines in a dose-dependent manner. The data support observed affected tumor cells with decrease in proliferation and their spatial distribution. Spectral absorption signatures are correlated with optical micrographs and western blot tests. These observations are mediated by surface scatterers out of silica glass material, form an essential step toward the development of early detection of response to cancer therapy.

Suggested Citation

Katiyi, Aviad and Zorea, Jonathan and Halstuch, Aviran and Elkabets, Moshe and Karabchevsky, Alina, Scattering-Induced Absorption Acts as a Cancer Treatment Monitor (July 29, 2019). ISCIENCE-D-19-00732. Available at SSRN: https://ssrn.com/abstract=3428483 or http://dx.doi.org/10.2139/ssrn.3428483
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Aviad Katiyi

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering ( email )

Beer-Sheva, 8410501
Israel

Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology ( email )

Beer-Sheva, 8410501
Israel

Ben-Gurion University of the Negev - Center for Quantum Information Science and Technology ( email )

Beer-Sheva, 8410501
Israel

Jonathan Zorea

Ben-Gurion University of the Negev - The Shraga Segal Department of Microbiology, Immunology and Genetics

Beer-Sheva, 8410501
Israel

Aviran Halstuch

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering

Beer-Sheva, 8410501
Israel

Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology

Beer-Sheva, 8410501
Israel

Moshe Elkabets

Ben-Gurion University of the Negev - The Shraga Segal Department of Microbiology, Immunology and Genetics

Beer-Sheva, 8410501
Israel

Alina Karabchevsky (Contact Author)

Ben-Gurion University of the Negev - School of Electrical and Computer Engineering ( email )

Beer-Sheva, 8410501
Israel

Ben-Gurion University of the Negev - Ilse Katz Institute for Nanoscale Science & Technology ( email )

Beer-Sheva, 8410501
Israel

Ben-Gurion University of the Negev - Center for Quantum Information Science and Technology ( email )

Beer-Sheva, 8410501
Israel

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