puc-header

A Basis Set of Elementary Operations Captures Recombination of Neocortical Cell Assemblies During Basal Conditions and Learning

57 Pages Posted: 20 Aug 2019 Publication Status: Review Complete

See all articles by Dominik F. Aschauer

Dominik F. Aschauer

Johannes Gutenberg University Mainz - Institute of Physiology

Jens-Bastian Eppler

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies

Luke Ewig

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies

Anna Chambers

Johannes Gutenberg University Mainz - Institute of Physiology

Christoph Pokorny

Graz University of Technology - Institute of Theoretical Computer Science

Matthias Kaschube

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies

Simon Rumpel

Johannes Gutenberg University Mainz - Institute of Physiology

More...

Abstract

Cell assemblies — subgroups within neuronal networks — are believed to serve as functional entities underlying cognitive capabilities such as categorical perception or memory formation and storage. However, little is known about their long-term dynamics. Using chronic in vivo calcium imaging in the mouse auditory cortex, we find that cell assemblies undergo continuous recombination, even under behaviorally stable conditions. We identify a basis set of elementary operations capturing the dynamics of cell assemblies, which involve plasticity of both the stimulus tuning of particular assemblies as well as the cellular composition of an assembly. Auditory fear conditioning introduces biases in the frequency of specific cell assembly operations that lead to increased association of representations and improved sound encoding. Thus, decomposing cell assembly dynamics during basal conditions into a basis set of elementary operations provides a general framework to explain learning-induced changes in global population activity.

Keywords: Mouse, Auditory cortex, Population coding, Perception, Two-photon microscopy, Calcium imaging, Cell assembly

Suggested Citation

Aschauer, Dominik F. and Eppler, Jens-Bastian and Ewig, Luke and Chambers, Anna and Pokorny, Christoph and Kaschube, Matthias and Rumpel, Simon, A Basis Set of Elementary Operations Captures Recombination of Neocortical Cell Assemblies During Basal Conditions and Learning (August 16, 2019). Available at SSRN: https://ssrn.com/abstract=3438457 or http://dx.doi.org/10.2139/ssrn.3438457
This version of the paper has not been formally peer reviewed.

Dominik F. Aschauer

Johannes Gutenberg University Mainz - Institute of Physiology ( email )

Duesbergweg 6
Mainz, D-55128
Germany

Jens-Bastian Eppler

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies

Frankfurt, 60483
Germany

Luke Ewig

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies

Frankfurt, 60483
Germany

Anna Chambers

Johannes Gutenberg University Mainz - Institute of Physiology

Duesbergweg 6
Mainz, D-55128
Germany

Christoph Pokorny

Graz University of Technology - Institute of Theoretical Computer Science

Austria

Matthias Kaschube

Goethe University Frankfurt - Frankfurt Institute for Advanced Studies ( email )

Frankfurt, 60483
Germany

Simon Rumpel (Contact Author)

Johannes Gutenberg University Mainz - Institute of Physiology

Duesbergweg 6
Mainz, D-55128
Germany

Click here to go to Cell.com

Paper statistics

Abstract Views
1,018
Downloads
50
PlumX Metrics