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Fruit Intake, Genetic Risk and Type 2 Diabetes: A Population Based Gene-Diet Interaction Analysis

37 Pages Posted: 22 Aug 2019

See all articles by Xu Jia

Xu Jia

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Wen Zhu

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Chanjuan Deng

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yanan Hou

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Liping Xuan

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Huajie Dai

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

More...

Abstract

Background: Dietary fruit intake was reported to be associated with protective effect on type 2 diabetes (T2D). Whether an interaction exists between fruit intake and genetic predisposition in T2D was yet elucidated. The aim of the study was to examine the gene-dietary fruit intake interactions on risk of T2D presence and related glycemic traits.

Methods: We recruited 11657 participants ≥ 40 years from a well-defined community-based population in Shanghai, China. Fruit intake was assessed by a qualified food frequency questionnaire. We created a T2D-genetic risk score (GRS) by including 34 established T2D common variants in East Asians.

Findings: We found that the risk of T2D associated with each 1-point of T2D-GRS was gradually decreased from lower fruit intake level (< 1 per week) to higher levels (1-3 and > 3 per week) (P for interaction = 0.037), the corresponding odds ratio and 95% CI were 1.097 (1.070-1.126), 1.075 (1.052-1.099) and 1.066 (1.048-1.084). Analyses for fasting, 2h-postprandial plasma glucose and hemoglobin glycated A1c demonstrated consistent tendencies (all P for interaction < 0.05). Vice versa, the inverse associations of fruit intake with risk of T2D and glucose traits were more prominent in the higher T2D-GRS tertile.

Interpretation: The genetic association of diabetes could be alleviated by higher fruit intake; the association of fruit intake with lower risk of diabetes could be strengthened by genetic predisposition of T2D.

Funding Statement: This study was supported by grants from the National Natural Science Foundation of China (81561128019, 81770842 and 81870604), the Ministry of Science and Technology of China (2018YFC1311705, 2016YFC1305600 and 2016YFC1304904), the Shanghai Science and Technology Commission (YDZX20173100004881) and the Shanghai Shen-Kang Hospital Development Center (SHDC12016202).

Declaration of Interests: The authors stated: "No potential conflicts of interest relevant to this article were reported."

Ethics Approval Statement: The Institutional Review Board of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, approved the study protocol. Each participant gave the written informed consent.

Keywords: diabetes; fruit intake; gene-diet interaction; genetic risk score; glycemic traits

Suggested Citation

Jia, Xu and Zhu, Wen and Deng, Chanjuan and Wang, Tiange and Hou, Yanan and Xuan, Liping and Dai, Huajie and Li, Mian and Zhao, Zhiyun and Xu, Yu and Lu, Jieli and Bi, Yufang and Wang, Weiqing and Chen, Yuhong and Xu, Min and Ning, Guang, Fruit Intake, Genetic Risk and Type 2 Diabetes: A Population Based Gene-Diet Interaction Analysis (08/19/2019 04:35:29). Available at SSRN: https://ssrn.com/abstract=3439547 or http://dx.doi.org/10.2139/ssrn.3439547

Xu Jia (Contact Author)

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Wen Zhu

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Chanjuan Deng

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yanan Hou

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Liping Xuan

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Huajie Dai

Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Medical Genomics

China

Mian Li

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yu Xu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Yufang Bi

Shanghai Jiao Tong University (SJTU) - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases

Shanghai
China

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Shanghai Clinical Center for Endocrine and Metabolic Diseases ( email )

Shanghai
China

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

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