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Gonadotropin Surge-Induced Expression of Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Ovulatory Inflammation

70 Pages Posted: 23 Aug 2019 Sneak Peek Status: Review Complete

See all articles by Chan Jin Park

Chan Jin Park

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Po-Ching Lin

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Radwa Barakat

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Sherry Zhou

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Jeong Moon Choi

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Joseph A. Cacioppo

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

Oliver R. Oakley

Eastern Kentucky University - Department of Biological Sciences

Diane M. Duffy

Eastern Virginia Medical School - Department of Physiological Sciences

John P. Lydon

Baylor University - Department of Molecular and Cell Biology

Chemyong Jay Ko

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

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Abstract

Ovulation is triggered by the gonadotropin surge that induces the expression of two key genes, progesterone receptor (Pgr) and prostaglandin-endoperoxide synthase 2 (Ptgs2) in the granulosa cells of preovulatory follicles. Their gene products PGR and PTGS2 activate two separate pathways that are both essential for successful ovulation. Here we show that the PGR plays an additional essential role; attenuate ovulatory inflammation by ending the gonadotropin surge-induced Ptgs2 expression. PGR indirectly terminates Ptgs2expression by inhibiting the NF-κB, a transcription factor required for Ptgs2 expression. When the expression of PGR was ablated in the granulosa cells, the ovary undergoes hyperinflammatory condition manifested by excessive PGE2 synthesis, immune cell infiltration, and oxidative damage. Despite the ovary undergoes ovulations dozens or hundreds of times in one’s lifetime, the repetitive ovulatory inflammations do not leave significant tissue damage in the ovary. The PGR-driven termination of PTGS2 expression may protect ovary from the ovulatory inflammation.

Keywords: Granulosa cells, Ovulation, Inflammation, PGR, PTGS2

Suggested Citation

Park, Chan Jin and Lin, Po-Ching and Barakat, Radwa and Zhou, Sherry and Choi, Jeong Moon and Cacioppo, Joseph A. and Oakley, Oliver R. and Duffy, Diane M. and Lydon, John P. and Ko, Chemyong Jay, Gonadotropin Surge-Induced Expression of Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Ovulatory Inflammation (August 21, 2019). CELL-REPORTS-D-19-03227. Available at SSRN: https://ssrn.com/abstract=3440906 or http://dx.doi.org/10.2139/ssrn.3440906
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Chan Jin Park

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Po-Ching Lin

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Radwa Barakat

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Sherry Zhou

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Jeong Moon Choi

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Joseph A. Cacioppo

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences

2001 South Lincoln Avenue
Urbana, IL 61802
United States

Oliver R. Oakley

Eastern Kentucky University - Department of Biological Sciences

United States

Diane M. Duffy

Eastern Virginia Medical School - Department of Physiological Sciences

United States

John P. Lydon

Baylor University - Department of Molecular and Cell Biology

United States

Chemyong Jay Ko (Contact Author)

University of Illinois at Urbana-Champaign - Department of Comparative Biosciences ( email )

2001 South Lincoln Avenue
Urbana, IL 61802
United States

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