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Projections of D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Drive Different Valence and Change in Speed

32 Pages Posted: 23 Aug 2019 Sneak Peek Status: Review Complete

See all articles by Yun Yao

Yun Yao

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering

Ge Gao

Tsinghua University - School of Life Sciences

Kai Liu

Tsinghua University - School of Life Sciences

Xin Shi

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering

Mingxiu Cheng

National Institute of Biological Sciences

Sen Song

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering; Tsinghua University - Center for Brain-Inspired Computing Researc

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Abstract

Nucleus accumbens (NAc) plays an important role in emotion and motivation. NAc D1 neurons are widely accepted to be associated with reward, while the role of D2 neurons are more evasive. D2 neurons are traditionally associated with aversion. However, some reports have attributed positive motivational roles to them. Here, we combined optogenetics and rabies-mediated transsynaptic tracing to demonstrate the anatomical and functional heterogeneity of NAc shell (NAcSh) D2 neurons. D2 neurons in the dorsomedial zone drive positive preference and increase reward motivation while D2 neurons in the ventral zones drive aversion and decrease reward motivation. Furthermore, D2 neurons in ventromedial NAcSh increase movement speed and those in the ventrolateral NAcSh decrease movement speed. D2 neurons in different subregions of NAcSh target downstream cell types differentially. Therefore, the finding of the heterogeneity in the anatomy and function of NAcSh D2 neurons clears up some of the controversy in the literature.

Keywords: Nucleus accumbens shell;Ventral Pallidum;Nucleus accumbens D2 neurons;Reward motivation, striatum

Suggested Citation

Yao, Yun and Gao, Ge and Liu, Kai and Shi, Xin and Cheng, Mingxiu and Song, Sen, Projections of D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Drive Different Valence and Change in Speed (August 22, 2019). CELL-REPORTS-D-19-03262. Available at SSRN: https://ssrn.com/abstract=3441420 or http://dx.doi.org/10.2139/ssrn.3441420
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Yun Yao

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering

Beijing, 100084
United States

Ge Gao

Tsinghua University - School of Life Sciences

Beijing, 100084
China

Kai Liu

Tsinghua University - School of Life Sciences

Beijing, 100084
China

Xin Shi

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering

Beijing, 100084
United States

Mingxiu Cheng

National Institute of Biological Sciences

7 Science Park Road
ZGC Life Science Park
Beijing, 102206
China

Sen Song (Contact Author)

Tsinghua University - Laboratory of Brain and Intelligence and Department of Biomedical Engineering ( email )

Beijing, 100084
United States

Tsinghua University - Center for Brain-Inspired Computing Researc ( email )

Beijing, 100084
China

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