puc-header

Tracking Dynamics of Spontaneous Tumours in Mice Using Photon Counting Computed Tomography

47 Pages Posted: 30 Aug 2019 Sneak Peek Status: Published

See all articles by Franca Cassol

Franca Cassol

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Loriane Portal

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Sylvie Richelme

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

Mathieu Dupont

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Yannick Boursier

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Maria Arechederra

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

Nathalie Auphan-Anezin

Aix Marseille Université - CIML

Lionel Chasson

Aix-Marseille University - CIML

Caroline Laprie

Aix-Marseille University - CIML

Samantha Fernandez

Aix-Marseille University - CERIMED

Laure Balasse

Aix-Marseille University - CERIMED

Fabienne Lamballe

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

Rosanna Dono

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

Benjamin Guillet

Aix-Marseille University - CERIMED

Toby Lawrence

Aix-Marseille University - CIML

Christian Morel

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Flavio Maina

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

More...

Abstract

Computed Tomography is a powerful medical imaging modality for longitudinal studies in cancer to follow neoplasia progression and evaluate anticancer therapies. Here, we report the generation of a new Photon Counting micro-Computed Tomography (PC-CT) method based on hybrid pixel detector with enhanced sensitivity and precision of tumour imaging. We then applied PC-CT for longitudinal imaging in a clinically relevant liver cancer model, the Alb-R26Met mice, and found a remarkable heterogeneity in the dynamics for tumours at the initiation phases. Instead, the growth curve of evolving tumours exhibited a comparable exponential growth, with a constant doubling time. Furthermore, longitudinal PC-CT imaging in mice treated with a combination of MEK and BCL-XL inhibitors revealed a drastic tumour regression accompanied by a striking remodelling of macrophages in the tumour microenvironment. Thus, PC-CT is a powerful system to detect cancer initiation and progression, and to monitor its evolution during treatment.

Suggested Citation

Cassol, Franca and Portal, Loriane and Richelme, Sylvie and Dupont, Mathieu and Boursier, Yannick and Arechederra, Maria and Auphan-Anezin, Nathalie and Chasson, Lionel and Laprie, Caroline and Fernandez, Samantha and Balasse, Laure and Lamballe, Fabienne and Dono, Rosanna and Guillet, Benjamin and Lawrence, Toby and Morel, Christian and Maina, Flavio, Tracking Dynamics of Spontaneous Tumours in Mice Using Photon Counting Computed Tomography (August 29, 2019). ISCIENCE-D-19-00788. Available at SSRN: https://ssrn.com/abstract=3445036 or http://dx.doi.org/10.2139/ssrn.3445036
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Franca Cassol

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Marseille
France

Loriane Portal

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Marseille
France

Sylvie Richelme

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

163 Avenue de Luminy
Marseille, 13009
France

Mathieu Dupont

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Marseille
France

Yannick Boursier

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Marseille
France

Maria Arechederra

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

163 Avenue de Luminy
Marseille, 13009
France

Nathalie Auphan-Anezin

Aix Marseille Université - CIML

Marseille
France

Lionel Chasson

Aix-Marseille University - CIML

Marseille
France

Caroline Laprie

Aix-Marseille University - CIML

Marseille
France

Samantha Fernandez

Aix-Marseille University - CERIMED

Marseille
France

Laure Balasse

Aix-Marseille University - CERIMED

Marseille
France

Fabienne Lamballe

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

163 Avenue de Luminy
Marseille, 13009
France

Rosanna Dono

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

163 Avenue de Luminy
Marseille, 13009
France

Benjamin Guillet

Aix-Marseille University - CERIMED

Marseille
France

Toby Lawrence

Aix-Marseille University - CIML

Marseille
France

Christian Morel

Aix-Marseille University - CPPM (Centre de Physique des Particules de Marseille)

Marseille
France

Flavio Maina (Contact Author)

Aix-Marseille University - Institut de Biologie du Développement de Marseille (IBDM)

163 Avenue de Luminy
Marseille, 13009
France

Click here to go to Cell.com

Go to Cell.com

Paper statistics

Abstract Views
124
Downloads
14