Correlation between Targeted Protein and Drug Side Effects: A Step towards the Prediction of Drug Toxicity

7 Pages Posted: 3 Sep 2019

See all articles by Agrimaa Singh Thakur

Agrimaa Singh Thakur

Panjab University - University Institute of Engineering and Technology

Preeti Aggarwal

Panjab University - University Institute of Engineering and Technology

Date Written: September 2, 2019

Abstract

Drug toxicity being a pressing health problem is additionally a hindrance in the improvement of therapeutically effective drugs. Adverse drug reactions continue to stay one of the fundamental reasons for the failure of drug and its withdrawal once they have accomplished the market. Extensive scale clinical investigations for finding such symptoms are exorbitant and may miss unpretentious or uncommon reactions or side effects. In this study, we start by discussing the various databases available that provide many drug-related features and then we further investigate the techniques used in the past to enhance the drugs side effects predictions on the basis of different features. We then calculate the correlation of the targeted proteins and side effect pairs. The results indicate their weak and strong dependency on each other. Also, the clustering of drugs is done based on their use in the treatment of various diseases and medical conditions which can be helpful further in the emerging field of pharmacology as there is still a room for improvement in predicting and understanding drug side effects.

Suggested Citation

Singh Thakur, Agrimaa and Aggarwal, Preeti, Correlation between Targeted Protein and Drug Side Effects: A Step towards the Prediction of Drug Toxicity (September 2, 2019). Proceedings of International Conference on Advancements in Computing & Management (ICACM) 2019. Available at SSRN: https://ssrn.com/abstract=3446550 or http://dx.doi.org/10.2139/ssrn.3446550

Agrimaa Singh Thakur (Contact Author)

Panjab University - University Institute of Engineering and Technology

Chandigarh
India

Preeti Aggarwal

Panjab University - University Institute of Engineering and Technology ( email )

Chandigarh
India

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