puc-header

Entorhinal Cholecystokinin Enables Theta-Burst Stimulation-Induced Hippocampal LTP and Transfer of Spatial Memory

79 Pages Posted: 10 Sep 2019 Sneak Peek Status: Under Review

See all articles by Junfeng Su

Junfeng Su

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

Wenxi Ye

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Hui Liu

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Bingwen Zhang

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Peter Jendrichovsky

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

Anh Duc Hoang

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

Xi Chen

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

C.Y. Geoffrey Lau

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

Daiguan Yu

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Wenjun Xiong

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

Micky Tortorella

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Jufang He

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

More...

Abstract

Cholecystokinin (CCK) is purported to be involved in neuroplasticity and memory encoding.  Here we found that CCK from the medial entorhinal (MEC) to hippocampus projections facilitated CA3-CA1 long-term potentiation (LTP), which further enabled spatial memory transfer. CCK knockout mice lacked theta-burst stimulation-induced CA3-CA1 LTP and their spatial memory were compromised. Upon high-frequency optical activation, the MEC CCKergic terminals in the hippocampus released CCK and induced CA3-CA1 LTP, mainly through CCK A receptors. However, down-regulation of the MEC Cck expression impaired LTP. Stimulation of hippocampal CCK neurons, the Schaffer Collaterals, or the inhibitory MEC to hippocampus terminals, induced no CA3-CA1 LTP. Activation of a group of CA1 pyramidal neurons when the mouse visited a certain place of an arena, induced primed place cells (PPCs). The CCK-strengthened connectivity of two groups of PPCs enabled the transfer of fear memory from one place to another, implicating CCK’s determining role in spatial memory encoding.

Keywords: CCKAR, long-term potentiation, spatial fear memory, temporoammonic path, primed place cells

Suggested Citation

Su, Junfeng and Ye, Wenxi and Liu, Hui and Zhang, Bingwen and Jendrichovsky, Peter and Hoang, Anh Duc and Chen, Xi and Lau, C.Y. Geoffrey and Yu, Daiguan and Xiong, Wenjun and Tortorella, Micky and He, Jufang, Entorhinal Cholecystokinin Enables Theta-Burst Stimulation-Induced Hippocampal LTP and Transfer of Spatial Memory (September 10, 2019). NEURON-D-19-01386. Available at SSRN: https://ssrn.com/abstract=3451411 or http://dx.doi.org/10.2139/ssrn.3451411
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Junfeng Su

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Wenxi Ye

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology ( email )

Guangzhou, 510530
China

Hui Liu

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Guangzhou, 510530
China

Bingwen Zhang

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology

Guangzhou, 510530
China

Peter Jendrichovsky

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Anh Duc Hoang

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Xi Chen

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences

China

C.Y. Geoffrey Lau

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Daiguan Yu

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology ( email )

Guangzhou, 510530
China

Wenjun Xiong

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Micky Tortorella

Chinese Academy of Sciences (CAS) - Key Laboratory of Regenerative Biology ( email )

Guangzhou, 510530
China

Jufang He (Contact Author)

City University of Hong Kong (CityUHK) - Department of Biomedical Sciences ( email )

China

Click here to go to Cell.com

Go to Cell.com

Paper statistics

Abstract Views
69
Downloads
4