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Acute Plasmodium Infection Promotes Interferon-Gamma Dependent Resistance to Ebola Virus Infection

37 Pages Posted: 14 Sep 2019 Sneak Peek Status: Under Review

See all articles by Kai Rogers

Kai Rogers

University of Iowa - Department of Microbiology and Immunology

Olena Shtanko

Texas Biomedical Research Institute

Rajul Vijay

University of Iowa - Department of Microbiology and Immunology

Laura Mallinger

University of Iowa - Department of Microbiology and Immunology

Chester Joyner

Emory University

Mary Galinski

Emory University

Noah Butler

University of Iowa - Department of Microbiology and Immunology

Wendy Maury

University of Iowa - Department of Microbiology and Immunology

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Abstract

During the 2013-2016 Ebola virus epidemic, a significant number of patients admitted to Ebola Treatment Units were co-infected with Plasmodium falciparum, a predominant agent of malaria. However, there is no consensus on how malaria impacts EBOV infection. The effect of acute Plasmodium infection on EBOV challenge was investigated using mouse adapted Ebola virus and a BSL-2 model virus. We demonstrate that acute Plasmodium infection protects from lethal viral challenge, dependent upon interferon gamma (IFN-γ) elicited as a result of parasite infection. Plasmodium-infected mice lacking the IFN-γ receptor were not protected. Ex vivo incubation of naïve human or mouse macrophages with sera from acutely parasitemic animals programmed a proinflammatory phenotype dependent on IFN-γ and rendered cells resistant to EBOV infection. We conclude that acute Plasmodium infection can safeguard against EBOV by production of protective IFN-γ. These findings have implications for anti-malaria therapies administered during episodic EBOV outbreaks in Africa.

Keywords: Plasmodium, Ebola virus, Macrophage polarization, Co-infection, Interferon gamma, malaria, Filovirus:Pro-inflammatory

Suggested Citation

Rogers, Kai and Shtanko, Olena and Vijay, Rajul and Mallinger, Laura and Joyner, Chester and Galinski, Mary and Butler, Noah and Maury, Wendy, Acute Plasmodium Infection Promotes Interferon-Gamma Dependent Resistance to Ebola Virus Infection (September 10, 2019). CELL-REPORTS-D-19-03486. Available at SSRN: https://ssrn.com/abstract=3452781 or http://dx.doi.org/10.2139/ssrn.3452781
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Kai Rogers

University of Iowa - Department of Microbiology and Immunology ( email )

United States

Olena Shtanko

Texas Biomedical Research Institute ( email )

8715 W Military Drive
San Antonio, TX 78227
United States

Rajul Vijay

University of Iowa - Department of Microbiology and Immunology ( email )

United States

Laura Mallinger

University of Iowa - Department of Microbiology and Immunology ( email )

United States

Chester Joyner

Emory University ( email )

201 Dowman Drive
Atlanta, GA 30322
United States

Mary Galinski

Emory University ( email )

201 Dowman Drive
Atlanta, GA 30322
United States

Noah Butler

University of Iowa - Department of Microbiology and Immunology ( email )

United States

Wendy Maury (Contact Author)

University of Iowa - Department of Microbiology and Immunology

United States

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