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A New Method Prevents Catheter Associated Urinary Tract Infection by Inhibiting Bacterial Biofilm Formation on Catheters in Catheterized Patients

27 Pages Posted: 18 Sep 2019

See all articles by Zhangqun Ye

Zhangqun Ye

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital

Zhiping Wang

Lanzhou University

Wei He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital

Peifen Ma

Lanzhou University

Lu Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital

Dongmin Wang

Lanzhou University

Xin Li

Beijing Hospital

Xinqiao Wen

Sun Yat-Sen University (SYSU) - Third Affiliated Hospital

Yi Zuo

Southern Medical University - Nanfang Hospital

Qin Guo

Southern Medical University - Nanfang Hospital

Yanhong Zhang

Southern Medical University - Nanfang Hospital

Ru Cheng

Tianjin Medical University

More...

Abstract

Background: Catheter associated urinary tract infection (CAUTI) remains the most important dilemma in hospital acquired infections (HAIs), which is still unresolved. We aimed to introduce a physical antimicrobial method to reduce the risk of CAUTI.

Methods: In this multicenter, randomized, double-blind study, we enrolled adults who suffered from acute urinary retention (AUR) and required catheterization in 13 hospitals in China. Participants were randomly allocated 1:1 according to a random number table to receive JUC spray dressing or placebo (normal saline, NS). Urine samples and catheter samples were collected after catheterization by trial staff for further investigation.

Results: Between April, 2012 and April, 2014, we enrolled 264 patients and randomly assigned them to the JUC group (n=132) and the placebo group (n=132). Clinical symptoms and urine bacterial cultures showed the incidence of CAUTI of the JUC group was significantly lower than that of the placebo group (P < 0.01). Another 30 patients were recruited to evaluate the biofilm formation (10 groups, n=3 in each group) on catheters in catheterized patients. Scanning electronic microscope (SEM) results demonstrated that in the placebo group, bacterial biofilm was formed on day 5, and in JUC group, no bacterial biofilm was formed on day 5.

Conclusion: Bacterial biofilm formation on catheters implanted in patients was confirmed for the first time and JUC spray dressing could significantly decrease the incidence of CAUTI by forming a layer of physical antimicrobial film to prevent bacterial biofilm formation on the catheters, which provides an innovative approach for controlling CAUTI.

Funding Statement: National Natural Science Foundation of China.

Declaration of Interest: We have no conflicts of interest to disclose.

Ethical Approval Statement: The trial was approved by the Chinese Ethics Committee of Registering Clinical Trials (approval No. ChiECRCT-2012021), registered at the Chinese Clinical Trial Registry (Registration No. ChiCTR-TRC-12002562) and conducted in accordance with the latest version of the Declaration of Helsinki after all participants signed informed consent.

Suggested Citation

Ye, Zhangqun and Wang, Zhiping and He, Wei and Ma, Peifen and Li, Lu and Wang, Dongmin and Li, Xin and Wen, Xinqiao and Zuo, Yi and Guo, Qin and Zhang, Yanhong and Cheng, Ru, A New Method Prevents Catheter Associated Urinary Tract Infection by Inhibiting Bacterial Biofilm Formation on Catheters in Catheterized Patients (September 13, 2019). Available at SSRN: https://ssrn.com/abstract=3453334 or http://dx.doi.org/10.2139/ssrn.3453334

Zhangqun Ye (Contact Author)

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital ( email )

1239 Siping Road
Shanghai, 200092
China

Zhiping Wang

Lanzhou University ( email )

222 Tianshui South Road
Chengguan
Lanzhou, gansu 730000
China

Wei He

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital

1239 Siping Road
Shanghai, 200092
China

Peifen Ma

Lanzhou University

222 Tianshui South Road
Chengguan
Lanzhou, gansu 730000
China

Lu Li

Huazhong University of Science and Technology (Formerly Tongi Medical University) - Tongji Hospital

1239 Siping Road
Shanghai, 200092
China

Dongmin Wang

Lanzhou University

222 Tianshui South Road
Chengguan
Lanzhou, gansu 730000
China

Xin Li

Beijing Hospital

China

Xinqiao Wen

Sun Yat-Sen University (SYSU) - Third Affiliated Hospital

No.600, Tianhe Road
Guangzhou, 510630
China

Yi Zuo

Southern Medical University - Nanfang Hospital

Guangzhou, Guangdong Province
China

Qin Guo

Southern Medical University - Nanfang Hospital

Guangzhou, Guangdong Province
China

Yanhong Zhang

Southern Medical University - Nanfang Hospital

Guangzhou, Guangdong Province
China

Ru Cheng

Tianjin Medical University

Tianjin Shi
China

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