Quality Evaluation of Midazolam Hydrochloride Injection Prepared at the Intensive Care Unit of Dr. Soetomo Hospital

5 Pages Posted: 11 Oct 2019 Last revised: 6 Dec 2019

See all articles by M.D. Wulandari

M.D. Wulandari

Dr. Soetomo Hospital

Andang Miatmoko

Airlangga University

N Aryanti

Dr. Soetomo Hospital

E.B. Warsito

Dr. Soetomo Hospital

Date Written: September 30, 2019

Abstract

Midazolam hydrochloride (MDZ) is a benzodiazepine drug, characterized as a high alert medicine, which is frequently prescribed in the Intensive Care Unit (ICU) of Dr. Soetomo Hospital, Surabaya, Indonesia. This study is, therefore, aimed at evaluating the physicochemical and microbiological stability of 1 mg/mL MDZ solution, prepared by nurses in the ICU of Dr. Soetomo Hospital, Surabaya. The samples were prepared by aseptic techniques using alcohol swap and subsequently stored in different containers, i.e. injection syringe and glass vial, at room and cold temperatures. Furthermore, the samples were evaluated 24 hours after preparation, and the result showed no significant difference in solution clarity, pH, as well as MDZ content, and no microbial contamination was observed. In conclusion, it is suggested that the use of alcohol swab techniques, and diluted MDZ solution prepared in ICU, had good stability and feasible for use on patients.

Keywords: midazolam hydrochloride, pH stability, microbial contamination, HPLC, alcohol swab

Suggested Citation

Wulandari, Mela Dwi and Miatmoko, Andang and Aryanti, N and Warsito, E.B., Quality Evaluation of Midazolam Hydrochloride Injection Prepared at the Intensive Care Unit of Dr. Soetomo Hospital (September 30, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018, Available at SSRN: https://ssrn.com/abstract=3461433 or http://dx.doi.org/10.2139/ssrn.3461433

Mela Dwi Wulandari

Dr. Soetomo Hospital ( email )

Jl. Prof. Dr. Moestopo 6-8
Surabaya, East Java 60286
Indonesia

Andang Miatmoko (Contact Author)

Airlangga University ( email )

Jl. Darmawangsa Dalam 2
Surabaya, 60286
Indonesia

N Aryanti

Dr. Soetomo Hospital

Jl. Prof. Dr. Moestopo 6-8
Surabaya, East Java 60286
Indonesia

HOME PAGE: http://rsudrsoetomo.jatimprov.go.id/

E.B. Warsito

Dr. Soetomo Hospital

Jl. Prof. Dr. Moestopo 6-8
Surabaya, East Java 60286
Indonesia

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