Cocrystallization of Loratadine With Succinic Acid Using Neat Grinding Method

6 Pages Posted: 11 Oct 2019 Last revised: 6 Dec 2019

See all articles by Dwi Setyawan

Dwi Setyawan

Faculty of Pharmacy, Airlangga University

E.R.D. Pravianti

Airlangga University - Faculty of Pharmacy, Airlangga University

K.D. Pratiwi

Airlangga University - Faculty of Pharmacy, Airlangga University

D. Isadiartuti

Airlangga University - Faculty of Pharmacy, Airlangga University

D.P. Paramita

Airlangga University - Faculty of Pharmacy, Airlangga University

Date Written: September 30, 2019

Abstract

Cocrystal of loratadine (L) was produced using succinic acid (SA), in order to improve the poor aqueous solubility profile. This was prepared in molar ratio of 1:1 (CC1) and 1:2 (CC2), applying the neat grinding method, therefore, the physicochemical properties and in vitro dissolution of both were characterized in free CO2 aquadest. The thermogram DSC of CC1 exhibited single endothermic peak at 116.8°C, two peaks were seen in CC2, at 90.2 and 152.2°C, and L had one, at 137.5°C. In addition, the results of XRPD showed a new peak at 2θ 21.93° and 21.88°, respectively, while C=O and –OH band shifts were identified in the FTIR spectra of both preparations. SEM photomicrographs revealed particle size reduction without habit alteration, while physicochemical characterization confirmed the incomplete cocrystal formation of loratadine with succinic acid, which promotes efficiency dissolution (DE15), in contrast with loratadine.

Keywords: loratadine, succinic acid, cocrystal, physical characterization, dissolution

Suggested Citation

Setyawan, Dwi and Pravianti, E.R.D. and Pratiwi, K.D. and Isadiartuti, D. and Paramita, D.P., Cocrystallization of Loratadine With Succinic Acid Using Neat Grinding Method (September 30, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018, Available at SSRN: https://ssrn.com/abstract=3461442 or http://dx.doi.org/10.2139/ssrn.3461442

Dwi Setyawan (Contact Author)

Faculty of Pharmacy, Airlangga University ( email )

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

E.R.D. Pravianti

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

K.D. Pratiwi

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

D. Isadiartuti

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

D.P. Paramita

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

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