The Effect of Chitosan Type and Concentration on Physical Characteristics and Drug Release Behavior of Andrographolide-Chitosan Microparticles Prepared by Ionic Gelation – Freeze Drying

9 Pages Posted: 11 Oct 2019 Last revised: 6 Dec 2019

See all articles by Retno Sari

Retno Sari

Faculty of Pharmacy, Airlangga University

M.L.L. Sugiarto

Airlangga University - Faculty of Pharmacy, Airlangga University

W. Amirah

Airlangga University - Faculty of Pharmacy, Airlangga University

H. Yusuf

Airlangga University - Faculty of Pharmacy, Airlangga University

Date Written: September 30, 2019

Abstract

Andrographolide is low in solubility and bioavailability, with short half-life (t1/2 = 1.5-2 hours), with chitosan micro-particles expected to improve its dissolution. Therefore, the objective of this research was to investigate the effect of chitosan concentration and the in vitro release of andrographolide from micro-particles prepared by ionic gelation using sodium tripolyphosphate (TPP) as cross-linker. Furthermore, the micro-particles used were prepared with two different concentration of chitosan namely 19 cPs and 50 cPs. The result showed that the micro-particles obtained were spherical in shape and heterogeneous in size, with Infrared spectra indicating ionic bonding between chitosan and TPP. The DTA thermogram and XRD diffractogram exhibited a change in crystal structure to a more amorphous form. The entrapment efficiency (EE) of andrographolide in micro-particles was about 78%, with no impact on the chitosan concentrations (19 cPs and 50 cPs) affected by EE. The kinetics released was followed by the Higuchi model in phosphate buffer, with pH 7 ± 0,05 higher than the andrographolide substance. It was investigated that andrographolide-chitosan micro-particles had the ability to enhance its dissolution rate.

Keywords: microparticle, andrographolide, chitosan, ionic gelation, drug release

Suggested Citation

Sari, Retno and Sugiarto, M.L.L. and Amirah, W. and Yusuf, H., The Effect of Chitosan Type and Concentration on Physical Characteristics and Drug Release Behavior of Andrographolide-Chitosan Microparticles Prepared by Ionic Gelation – Freeze Drying (September 30, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018, Available at SSRN: https://ssrn.com/abstract=3461443 or http://dx.doi.org/10.2139/ssrn.3461443

Retno Sari (Contact Author)

Faculty of Pharmacy, Airlangga University ( email )

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

M.L.L. Sugiarto

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

W. Amirah

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

H. Yusuf

Airlangga University - Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia

HOME PAGE: http://ff.unair.ac.id/

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