The Gut Microbiota Drives Metabolic Disorders Which Compromise Sociability in Alcoholic Patients
74 Pages Posted: 1 Oct 2019 Sneak Peek Status: Under ReviewMore...
Patients with alcohol use disorder (AUD) present with important emotional, cognitive and social impairments. The gut microbiota has been recently shown to regulate brain functions and behavior but convincing evidence of its role in AUD is lacking. Here, we show for the first time that the gut microbiota drives behavioral features of alcohol addiction including reduced sociability. By transplanting the gut microbiota from AUD patients to mice, we pointed out that the production of ethanol by specific bacterial genera, is associated with a lower hepatic synthesis of beta-hydroxybutyrate (BHB), and thereby prevent the protective effect of BHB on social behavior, neuroinflammation and neurotransmission. We confirmed this hypothesis detoxified AUD patients, in which we observed a persisting ethanol production in the feces as well as correlations between low plasma BHB levels and social impairments. Our data support new pathways involved in behavioral disorders associated with alcohol addiction, that could be considered for future treatments.
Keywords: gut microbiota, gut-brain axis, sociability: metabolomics, ethanol, β-hydroxybutyrate, liver, ketogenic diet, alcoholism, addiction
Suggested Citation: Suggested Citation