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Coding Variant In LEP Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity

452 Pages Posted: 23 Oct 2019 Publication Status: Review Complete

See all articles by Hanieh Yaghootkar

Hanieh Yaghootkar

University of Exeter - Genetics of Complex Traits

Yiying Zhang

Columbia University

Cassandra N. Spracklen

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

Tugce Karaderi

University of Oxford - Wellcome Trust Centre for Human Genetics

Lam Opal Huang

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Jonathan Bradfield

The Children's Hospital of Philadelphia - Center for Applied Genomics

Claudia Schurmann

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

Rebecca S. Fine

Harvard University - Department of Genetics

Michael H. Preuss

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

Zoltan Kutalik

University of Exeter - Genetics of Complex Traits

Laura BL Wittemans

University of Oxford - Wellcome Trust Centre for Human Genetics

Yingchang Lu

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

Sophia Metz

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Sara M. Willems

University of Cambridge

Ruifang Li-Gao

Leiden University - Leiden University Medical Center (LUMC)

Niels Grarup

University of Copenhagen - Novo Nordisk Foundation Center for Protein Research

Shuai Wang

Boston University - Department of Biostatistics

Sophie Molnos

German Center for Diabetes Research

América A. Sandoval-Zárate

Institute for Molecular Medicine Finland (FIMM)

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Leslie A. Lange

University of Colorado at Denver

Jeffrey Haesser

Fred Hutchinson Cancer Research Center - Public Health Sciences Division

Xiuqing Guo

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Leo-Pekka Lyytikäinen

Tampere University - Department of Clinical Chemistry

Mary F. Feitosa

Washington University in St. Louis

Colleen M. Sitlani

University of Washington

Cristina Venturini

King's College London - Department of Twin Research and Genetic Epidemiology

Anubha Mahajan

University of Oxford - Wellcome Trust Centre for Human Genetics

Tim Kacprowski

University Medicine Greifswald

Carol A. Wang

Boston University - Department of Biostatistics

Daniel I. Chasman

Brigham and Women's Hospital

Najaf Amin

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Linda Broer

Erasmus University Rotterdam (EUR) - Department of Internal Medicine

Neil Robertson

University of Oxford - Wellcome Trust Centre for Human Genetics

Kristin L. Young

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Matthew Allison

University of California, San Diego (UCSD) - Department of Family Medicine and Public Health

Paul L. Auer

University of Wisconsin - Milwaukee

Matthias Blüher

University of Leipzig - Department of Medicine

Judith B. Borja

Universidad de San Carlo de Guatemala

Jette Bork-Jensen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Germán D. Carrasquilla

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Paraskevi Christofidou

King's College London - Department of Twin Research and Genetic Epidemiology

Ayse Demirkan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Claudia A. Doege

Columbia University - Department of Pathology and Cell Biology

Melissa E. Garcia

National Heart, Lung, and Blood Institute

Mariaelisa Graff

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Kaiying Guo

Columbia University

Hakon Hakonarson

The Children’s Hospital of Philadelphia - Center for Applied Genomics; University of Pennsylvania - Department of Pediatrics; University of Pennsylvania - Division of Human Genetics

Jaeyoung Hong

Boston University - Department of Biostatistics

Yii-Der Ida Chen

UCLA Medical Center

Rebecca Jackson

Ohio State University (OSU)

Hermina Jakupović

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Pekka Jousilahti

National Institute for Health and Welfare

Anne E. Justice

Center for Biomedical and Translational Informatics

Mika Kähönen

Tampere University - Tampere University Hospital

Jorge R. Kizer

University of California, San Diego (UCSD)

Jennifer Kriebel

German Center for Diabetes Research

Charles A. LeDuc

Columbia University

Jin Li

Stanford University

Lars Lind

Uppsala University - Department of Medical Sciences

Jian’an Luan

University of Cambridge - MRC Epidemiology Unit

David Mackey

University of Western Australia - Centre for Ophthalmology and Visual Science

Massimo Mangino

King's College London - Department of Twin Research and Genetic Epidemiology

Satu Männistö

National Institute for Health and Welfare

Jayne F. Martin Carli

Columbia University

Carolina Medina-Gomez

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Dennis O. Mook-Kanamori

Leiden University

Andrew P. Morris

University of Liverpool - Department of Biostatistics

Renée de Mutsert

Leiden University

Matthias Nauck

University of Greifswald - University Medicine Greifswald

Ivana Nedeljkovic

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Craig E. Pennell

Boston University - Department of Biostatistics

Arund D. Pradhan

Brigham and Women's Hospital

Bruce M. Psaty

University of Washington

Olli T. Raitakari

Turku University Hospital

Robert A. Scott

University of Cambridge - MRC Epidemiology Unit

Tea Skaaby

Bispebjerg and Frederiksberg Hospitals

Konstantin Strauch

Helmholtz Zentrum München Research Center for Environmental Health

Kent D. Taylor

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Alexander Teumer

University of Greifswald - University Medicine Greifswald

Andre G. Uitterlinden

Erasmus University Rotterdam (EUR), Medical Center, Department of Internal Medicine ; Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Ying Wu

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

Jie Yao

UCLA Medical Center

Mark Walker

University of Newcastle - Institute of Cellular Medicine

Kari E. North

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Peter Kovacs

University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases

M. Arfan Ikram

Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Cornelia M. van Duijn

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Paul M. Ridker

Brigham and Women's Hospital

Stephen Lye

Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Research Centre for Women’s and Infants’ Health; University of Toronto - Department of Obstetrics and Gynaecology; University of Toronto, Faculty of Medicine, Department of Physiology

Georg Homuth

University Medicine Greifswald

Erik Ingelsson

Stanford University - Division of Cardiology

Timothy D. Spector

King's College London, Department of Twin Research and Genetic Epidemiology

Barbara McKnight

University of Washington - Department of Biostatistics

Michael A. Province

Washington University in St. Louis

Terho Lehtimäki

University of Turku

Linda Adair

Nutrition Epidemiology Division, UNC-CH

Jerome I. Rotter

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Alexander P. Reiner

Fred Hutchinson Cancer Research Center - Public Health Sciences Division

James G. Wilson

University of Mississippi - Medical Center

Tamara Harris

Government of the United States of America - Laboratory of Epidemiology, Demography, and Biometry

Samuli Ripatti

Masssachusetts Institute of Technology and Harvard University - Broad Institute

Harald Grallert

German Center for Diabetes Research; Helmholtz Zentrum München - Institute of Epidemiology (EPI)

James B. Meigs

Massachusetts General Hospital

Veikko Salomaa

National Institute for Health and Welfare

Torben Hansen

University of Copenhagen - Faculty of Health and Medical Sciences

Ko Willems van Dijk

Leiden University - Division of Endocrinology

Nicholas J. Wareham

University of Cambridge - Department of Public Health and Primary Care

Struan FA Grant

The Children's Hospital of Philadelphia - Center for Applied Genomics

Claudia Langenberg

University of Cambridge - MRC Epidemiology Unit; Government of the United Kingdom - Public Health England; Francis Crick Institute

Timothy M. Frayling

University of Exeter - Genetics of Complex Traits

Cecilia M. Lindgren

Masssachusetts Institute of Technology and Harvard University - Broad Institute

Karen L. Mohlke

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

Rudolph L. Leibel

Columbia University

Ruth JF Loos

Icahn School of Medicine at Mount Sinai - Mindich Child Health and Development Institute

Tuomas O. Kilpeläinen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

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Abstract

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin concentrations in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We confirmed five previously established and identified five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The novel missense Val94Met (rs17151919) variant in LEP was common in individuals with African ancestry ( minor allele frequency ( MAF) AFR=8%; MAFEUR=0.02%) and was associated with 0.34 standard deviations lower leptin concentrations per Met94 allele in adults (P=2x10-16, n=3,901). Using in vitro analyses, we showed that the Met94 allele decreases leptin secretion (P=0.025). The Met94 allele was associated with higher BMI in young African-ancestry children (P=0.002, n=2,030) but not in adults, suggesting leptin regulates early adiposity.

Keywords: Leptin, adiposity, exome-targeted array, GWAS, obesity

Suggested Citation

Yaghootkar, Hanieh and Zhang, Yiying and Spracklen, Cassandra N. and Karaderi, Tugce and Huang, Lam Opal and Bradfield, Jonathan and Schurmann, Claudia and Fine, Rebecca S. and Preuss, Michael H. and Kutalik, Zoltan and Wittemans, Laura BL and Lu, Yingchang and Metz, Sophia and Willems, Sara M. and Li-Gao, Ruifang and Grarup, Niels and Wang, Shuai and Molnos, Sophie and Sandoval-Zárate, América A. and Nalls, Mike A. and Lange, Leslie A. and Haesser, Jeffrey and Guo, Xiuqing and Lyytikäinen, Leo-Pekka and Feitosa, Mary F. and Sitlani, Colleen M. and Venturini, Cristina and Mahajan, Anubha and Kacprowski, Tim and Wang, Carol A. and Chasman, Daniel I. and Amin, Najaf and Broer, Linda and Robertson, Neil and Young, Kristin L. and Allison, Matthew and Auer, Paul L. and Blüher, Matthias and Borja, Judith B. and Bork-Jensen, Jette and Carrasquilla, Germán D. and Christofidou, Paraskevi and Demirkan, Ayse and Doege, Claudia A. and Garcia, Melissa E. and Graff, Mariaelisa and Guo, Kaiying and Hakonarson, Hakon and Hong, Jaeyoung and Chen, Yii-Der Ida and Jackson, Rebecca and Jakupović, Hermina and Jousilahti, Pekka and Justice, Anne E. and Kähönen, Mika and Kizer, Jorge R. and Kriebel, Jennifer and LeDuc, Charles A. and Li, Jin and Lind, Lars and Luan, Jian’an and Mackey, David and Mangino, Massimo and Männistö, Satu and Martin Carli, Jayne F. and Medina-Gomez, Carolina and Mook-Kanamori, Dennis O. and Morris, Andrew P. and de Mutsert, Renée and Nauck, Matthias and Nedeljkovic, Ivana and Pennell, Craig E. and Pradhan, Arund D. and Psaty, Bruce M. and Raitakari, Olli T. and Scott, Robert A. and Skaaby, Tea and Strauch, Konstantin and Taylor, Kent D. and Teumer, Alexander and Uitterlinden, Andre G. and Wu, Ying and Yao, Jie and Walker, Mark and North, Kari E. and Kovacs, Peter and Ikram, M. Arfan and van Duijn, Cornelia M. and Ridker, Paul M. and Lye, Stephen and Homuth, Georg and Ingelsson, Erik and Spector, Timothy D. and McKnight, Barbara and Province, Michael A. and Lehtimäki, Terho and Adair, Linda and Rotter, Jerome I. and Reiner, Alexander P. and Wilson, James G. and Harris, Tamara and Ripatti, Samuli and Grallert, Harald and Meigs, James B. and Salomaa, Veikko and Hansen, Torben and van Dijk, Ko Willems and Wareham, Nicholas J. and Grant, Struan FA and Langenberg, Claudia and Frayling, Timothy M. and Lindgren, Cecilia M. and Mohlke, Karen L. and Leibel, Rudolph L. and Loos, Ruth JF and Kilpeläinen, Tuomas O., Coding Variant In LEP Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity (October 8, 2019). Available at SSRN: https://ssrn.com/abstract=3466334 or http://dx.doi.org/10.2139/ssrn.3466334
This version of the paper has not been formally peer reviewed.

Hanieh Yaghootkar (Contact Author)

University of Exeter - Genetics of Complex Traits ( email )

Exeter
United Kingdom

Yiying Zhang

Columbia University

3022 Broadway
New York, NY 10027
United States

Cassandra N. Spracklen

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

102 Ridge Road
Chapel Hill, NC 27514
United States

Tugce Karaderi

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Lam Opal Huang

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Jonathan Bradfield

The Children's Hospital of Philadelphia - Center for Applied Genomics

Philadelphia, PA 19004
United States

Claudia Schurmann

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Rebecca S. Fine

Harvard University - Department of Genetics

Boston, MA 02115
United States

Michael H. Preuss

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Zoltan Kutalik

University of Exeter - Genetics of Complex Traits

Exeter
United Kingdom

Laura BL Wittemans

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Yingchang Lu

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Sophia Metz

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Sara M. Willems

University of Cambridge

Ruifang Li-Gao

Leiden University - Leiden University Medical Center (LUMC)

Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands

Niels Grarup

University of Copenhagen - Novo Nordisk Foundation Center for Protein Research

Nørregade 10
Copenhagen, København DK-1165
Denmark

Shuai Wang

Boston University - Department of Biostatistics

Boston, MA
United States

Sophie Molnos

German Center for Diabetes Research

85764 Neuherberg
Germany

América A. Sandoval-Zárate

Institute for Molecular Medicine Finland (FIMM)

Helsinki, FIN-00014
Finland

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Bethseda, MD 20892
United States

Leslie A. Lange

University of Colorado at Denver

Box 173364
1250 14th Street
Denver, CO 80217
United States

Jeffrey Haesser

Fred Hutchinson Cancer Research Center - Public Health Sciences Division

1100 Fairview Avenue North
Seattle, WA 98109-1024
United States

Xiuqing Guo

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Leo-Pekka Lyytikäinen

Tampere University - Department of Clinical Chemistry

Tampere
Finland

Mary F. Feitosa

Washington University in St. Louis

One Brookings Drive
Campus Box 1208
Saint Louis, MO MO 63130-4899
United States

Colleen M. Sitlani

University of Washington

Seattle, WA 98195
United States

Cristina Venturini

King's College London - Department of Twin Research and Genetic Epidemiology

London
United Kingdom

Anubha Mahajan

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Tim Kacprowski

University Medicine Greifswald

Fleischmannstraße 8
Greifswald, 17475
Germany

Carol A. Wang

Boston University - Department of Biostatistics

Boston, MA
United States

Daniel I. Chasman

Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Najaf Amin

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Linda Broer

Erasmus University Rotterdam (EUR) - Department of Internal Medicine

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Neil Robertson

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Kristin L. Young

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Matthew Allison

University of California, San Diego (UCSD) - Department of Family Medicine and Public Health

United States

Paul L. Auer

University of Wisconsin - Milwaukee

Bolton Hall 802
3210 N. Maryland Ave.
Milwaukee, WI 53211
United States

Matthias Blüher

University of Leipzig - Department of Medicine

Germany

Judith B. Borja

Universidad de San Carlo de Guatemala

Cebu City
Philippines

Jette Bork-Jensen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Germán D. Carrasquilla

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Paraskevi Christofidou

King's College London - Department of Twin Research and Genetic Epidemiology

London
United Kingdom

Ayse Demirkan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Claudia A. Doege

Columbia University - Department of Pathology and Cell Biology

New York, NY 10032
United States

Melissa E. Garcia

National Heart, Lung, and Blood Institute

73 Mr. Wayte Avenue
Bethesda, MD 01702
United States

Mariaelisa Graff

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Kaiying Guo

Columbia University

3022 Broadway
New York, NY 10027
United States

Hakon Hakonarson

The Children’s Hospital of Philadelphia - Center for Applied Genomics ( email )

Philadelphia, PA 19004
United States

University of Pennsylvania - Department of Pediatrics ( email )

34th Street & Civic Center Boulevard
Philadelphia, PA 19104
United States

University of Pennsylvania - Division of Human Genetics ( email )

Philadelphia, PA 19104
United States

Jaeyoung Hong

Boston University - Department of Biostatistics

Boston, MA
United States

Yii-Der Ida Chen

UCLA Medical Center

Los Angeles, CA
United States

Rebecca Jackson

Ohio State University (OSU)

Blankenship Hall-2010
901 Woody Hayes Drive
Columbus, OH OH 43210
United States

Hermina Jakupović

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Pekka Jousilahti

National Institute for Health and Welfare

Helsinki
Finland

Anne E. Justice

Center for Biomedical and Translational Informatics

United States

Mika Kähönen

Tampere University - Tampere University Hospital

Tampere
Finland

Jorge R. Kizer

University of California, San Diego (UCSD)

9500 Gilman Drive
Mail Code 0502
La Jolla, CA 92093-0112
United States

Jennifer Kriebel

German Center for Diabetes Research

85764 Neuherberg
Germany

Charles A. LeDuc

Columbia University

3022 Broadway
New York, NY 10027
United States

Jin Li

Stanford University

Stanford, CA 94305
United States

Lars Lind

Uppsala University - Department of Medical Sciences

Uppsala
Sweden

Jian’an Luan

University of Cambridge - MRC Epidemiology Unit

United Kingdom

David Mackey

University of Western Australia - Centre for Ophthalmology and Visual Science ( email )

35 Stirling Highway
Crawley, Western Australia 6009
Australia

Massimo Mangino

King's College London - Department of Twin Research and Genetic Epidemiology

London
United Kingdom

Satu Männistö

National Institute for Health and Welfare

Helsinki
Finland

Jayne F. Martin Carli

Columbia University

3022 Broadway
New York, NY 10027
United States

Carolina Medina-Gomez

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Dennis O. Mook-Kanamori

Leiden University

Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands

Andrew P. Morris

University of Liverpool - Department of Biostatistics

United Kingdom

Renée De Mutsert

Leiden University

Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands

Matthias Nauck

University of Greifswald - University Medicine Greifswald

Fleischmannstraße 8
Greifswald, 17475
Germany

Ivana Nedeljkovic

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Craig E. Pennell

Boston University - Department of Biostatistics

Boston, MA
United States

Arund D. Pradhan

Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Bruce M. Psaty

University of Washington

Seattle, WA 98195
United States

Olli T. Raitakari

Turku University Hospital

Turku, 20014
Finland

Robert A. Scott

University of Cambridge - MRC Epidemiology Unit

United Kingdom

Tea Skaaby

Bispebjerg and Frederiksberg Hospitals

Bispebjerg Bakke 23
2400 København
Denmark

Konstantin Strauch

Helmholtz Zentrum München Research Center for Environmental Health

Ingolstaedter Landstraße 1
Neuherberg, Bavaria D-85764
Germany

Kent D. Taylor

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Alexander Teumer

University of Greifswald - University Medicine Greifswald

Fleischmannstraße 8
Greifswald, 17475
Germany

Andre G. Uitterlinden

Erasmus University Rotterdam (EUR), Medical Center, Department of Internal Medicine

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Rotterdam
Netherlands

Ying Wu

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

102 Ridge Road
Chapel Hill, NC 27514
United States

Jie Yao

UCLA Medical Center

Santa Monica, CA
United States

Mark Walker

University of Newcastle - Institute of Cellular Medicine

Framlington Place
United Kingdom

Kari E. North

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Peter Kovacs

University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases

Germany

M. Arfan Ikram

Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Rotterdam
Netherlands

Cornelia M. Van Duijn

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Paul M. Ridker

Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Stephen Lye

Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Research Centre for Women’s and Infants’ Health ( email )

Toronto
Canada

University of Toronto - Department of Obstetrics and Gynaecology

123 Edward Street, Suite 1200
Toronto, M5G1E2
Canada

University of Toronto, Faculty of Medicine, Department of Physiology

Medical Sciences Building, 3rd Floor
1 King's College Circle
Toronto
Canada

Georg Homuth

University Medicine Greifswald

Fleischmannstraße 8
Greifswald, 17475
Germany

Erik Ingelsson

Stanford University - Division of Cardiology

Stanford, CA
United States

Timothy D. Spector

King's College London, Department of Twin Research and Genetic Epidemiology

London
United Kingdom

Barbara McKnight

University of Washington - Department of Biostatistics

Seattle, WA 98195
United States

Michael A. Province

Washington University in St. Louis

One Brookings Drive
Campus Box 1208
Saint Louis, MO MO 63130-4899
United States

Terho Lehtimäki

University of Turku

Turku, 20014
Finland

Linda Adair

Nutrition Epidemiology Division, UNC-CH ( email )

Chapel Hill, NC 27599
United States

HOME PAGE: http://www.cpc.unc.edu/people/fellows/bio?person=adair

Jerome I. Rotter

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Alexander P. Reiner

Fred Hutchinson Cancer Research Center - Public Health Sciences Division

1100 Fairview Avenue North
Seattle, WA 98109-1024
United States

James G. Wilson

University of Mississippi - Medical Center

Jackson, MS 39216-4505
United States

Tamara Harris

Government of the United States of America - Laboratory of Epidemiology, Demography, and Biometry

251 Bayview Boulevard, Suite 100
Baltimore, MD 21224-6825
United States

Samuli Ripatti

Masssachusetts Institute of Technology and Harvard University - Broad Institute

415 Main Street
Cambridge, MA 02142
United States

Harald Grallert

German Center for Diabetes Research

85764 Neuherberg
Germany

Helmholtz Zentrum München - Institute of Epidemiology (EPI)

Neuherberg, Bavaria
Germany

James B. Meigs

Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Veikko Salomaa

National Institute for Health and Welfare

Helsinki
Finland

Torben Hansen

University of Copenhagen - Faculty of Health and Medical Sciences

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Ko Willems Van Dijk

Leiden University - Division of Endocrinology

Leiden
Netherlands

Nicholas J. Wareham

University of Cambridge - Department of Public Health and Primary Care

Cambridge
United Kingdom

Struan FA Grant

The Children's Hospital of Philadelphia - Center for Applied Genomics

Philadelphia, PA 19004
United States

Claudia Langenberg

University of Cambridge - MRC Epidemiology Unit

United Kingdom

Government of the United Kingdom - Public Health England

Wellington House
133-155 Waterloo Road
London, SE1 8UG
United Kingdom

Francis Crick Institute

1 Midland Road
London, NW1 1AT
United Kingdom

Timothy M. Frayling

University of Exeter - Genetics of Complex Traits

Exeter
United Kingdom

Cecilia M. Lindgren

Masssachusetts Institute of Technology and Harvard University - Broad Institute

415 Main Street
Cambridge, MA 02142
United States

Karen L. Mohlke

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

102 Ridge Road
Chapel Hill, NC 27514
United States

Rudolph L. Leibel

Columbia University

3022 Broadway
New York, NY 10027
United States

Ruth JF Loos

Icahn School of Medicine at Mount Sinai - Mindich Child Health and Development Institute

New York, NY
United States

Tuomas O. Kilpeläinen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

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