puc-header

Direct PPARγ Activation by L-Thyroxin and TETRAC Links Thyroid Hormone and PPAR Signaling

55 Pages Posted: 15 Oct 2019 Sneak Peek Status: Review Complete

See all articles by Leonie Gellrich

Leonie Gellrich

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Pascal Heitel

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Jan Heering

Fraunhofer Institute for Molecular Biology and Applied Ecology

Whitney Kilu

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Tamara Goebel

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Astrid Kahnt

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Silvia Arifi

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Julius Pollinger

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Werner Pogoda

Goethe University Frankfurt - Department of Forensic Toxicology

Alexander Paulke

Goethe University Frankfurt - Department of Forensic Toxicology

Dieter Steinhilber

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Ewgenij Proschak

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Mario Wurglics

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Manfred Schubert-Zsilavecz

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Apirat Chaikuad

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Stefan Knapp

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Iris Bischoff

Goethe University Frankfurt - Institute of Pharmaceutical Biology

Robert Fürst

Goethe University Frankfurt - Institute of Pharmaceutical Biology

Daniel Merk

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

More...

Abstract

Thyroid hormones (THs) operate numerous physiological processes through the nuclear thyroid hormone receptors and several other proteins. Here we report direct peroxisome proliferator-activated receptor gamma (PPARγ) and retinoid X receptor (RXR) activation by the T4 metabolite TETRAC at nanomolar affinity. We demonstrate that TETRAC is a highly active PPARγ agonist promoting PPARγ signaling in cell-free, cellular and in vivo settings suggesting that TETRAC and other THs are activators of PPARγ linking TH and PPAR signaling.

Keywords: endocrinology, structural biology, metabolism, peroxisome proliferator-activatedreceptor, lipid mediators

Suggested Citation

Gellrich, Leonie and Heitel, Pascal and Heering, Jan and Kilu, Whitney and Goebel, Tamara and Kahnt, Astrid and Arifi, Silvia and Pollinger, Julius and Pogoda, Werner and Paulke, Alexander and Steinhilber, Dieter and Proschak, Ewgenij and Wurglics, Mario and Schubert-Zsilavecz, Manfred and Chaikuad, Apirat and Knapp, Stefan and Bischoff, Iris and Fürst, Robert and Merk, Daniel, Direct PPARγ Activation by L-Thyroxin and TETRAC Links Thyroid Hormone and PPAR Signaling (October 11, 2019). Available at SSRN: https://ssrn.com/abstract=3467825 or http://dx.doi.org/10.2139/ssrn.3467825
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Leonie Gellrich

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Pascal Heitel

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Jan Heering

Fraunhofer Institute for Molecular Biology and Applied Ecology

Germany

Whitney Kilu

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Tamara Goebel

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Astrid Kahnt

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Silvia Arifi

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Julius Pollinger

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Werner Pogoda

Goethe University Frankfurt - Department of Forensic Toxicology

Kennedyallee 104
Frankfurt, D-60596
Germany

Alexander Paulke

Goethe University Frankfurt - Department of Forensic Toxicology

Kennedyallee 104
Frankfurt, D-60596
Germany

Dieter Steinhilber

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Ewgenij Proschak

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Mario Wurglics

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Manfred Schubert-Zsilavecz

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Apirat Chaikuad

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Stefan Knapp

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Iris Bischoff

Goethe University Frankfurt - Institute of Pharmaceutical Biology

Frankfurt
Germany

Robert Fürst

Goethe University Frankfurt - Institute of Pharmaceutical Biology

Frankfurt
Germany

Daniel Merk (Contact Author)

Goethe University Frankfurt - Institute of Pharmaceutical Chemistry ( email )

Max-von-Laue-Str. 9
Frankfurt, D-60438
Germany

Click here to go to Cell.com

Paper statistics

Abstract Views
419
Downloads
6