Direct PPARγ Activation by L-Thyroxin and TETRAC Links Thyroid Hormone and PPAR Signaling
55 Pages Posted: 15 Oct 2019 Sneak Peek Status: Review CompleteMore...
Thyroid hormones (THs) operate numerous physiological processes through the nuclear thyroid hormone receptors and several other proteins. Here we report direct peroxisome proliferator-activated receptor gamma (PPARγ) and retinoid X receptor (RXR) activation by the T4 metabolite TETRAC at nanomolar affinity. We demonstrate that TETRAC is a highly active PPARγ agonist promoting PPARγ signaling in cell-free, cellular and in vivo settings suggesting that TETRAC and other THs are activators of PPARγ linking TH and PPAR signaling.
Keywords: endocrinology, structural biology, metabolism, peroxisome proliferator-activatedreceptor, lipid mediators
Suggested Citation: Suggested Citation