Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation
99 Pages Posted: 1 Nov 2019 Publication Status: Review Complete
Natasha Ng
University of Oxford
Sara M. Willems
University of Cambridge
Juan Fernandez
University of Oxford - Wellcome Centre for Human Genetics
Rebecca S. Fine
Harvard University - Department of Genetics
Eleanor Wheeler
Wellcome Trust Sanger Institute
Jennifer Wessel
Indiana University - Department of Epidemiology and Biostatistics
Hidetoshi Kitajima
University of Oxford - Wellcome Centre for Human Genetics
Gaëlle Marenne
Wellcome Trust Sanger Institute
Jana K. Rundle
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Xueling Sim
National University of Singapore (NUS) - Saw Swee Hock School of Public Health
Hanieh Yeghootkar
University of Exeter - Medical School
Nicola L. Beer
University of Oxford
Anne Raimondo
University of Oxford
Andrei I. Tarasov
University of Oxford
Soren K. Thomsen
University of Oxford
Martijn van de Bunt
University of Oxford - Wellcome Centre for Human Genetics
Shuai Wang
Boston University - Department of Biostatistics
Sai Chen
University of Michigan at Ann Arbor
Yuning Chen
Boston University - Department of Biostatistics
Yii-Der Ida Chen
UCLA Medical Center
Hugoline G. de Haan
Leiden University - Leiden University Medical Center (LUMC)
Niels Grarup
University of Copenhagen - Novo Nordisk Foundation Center for Protein Research
Ruifang Li-Gao
Leiden University - Leiden University Medical Center (LUMC)
Tibor V. Varga
Lund University
Jennifer L Asimit
Wellcome Genome Campus - Wellcome Trust Sanger Institute; Wellcome Genome Campus - Wellcome Trust Sanger Institute
Shuang Feng
University of Michigan at Ann Arbor - School of Public Health
Rona J. Strawbridge
University of Glasgow - College of Medical, Veterinary & Life Sciences
Erica L. Kleinbrink
Wayne State University
Tarunveer S. Ahluwalia
University of Copenhagen - Herlev Hospital
Ping An
Washington University in St. Louis - Department of Genetics
Emil V. Appel
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Dan E Arking
Johns Hopkins University - School of Medicine
Juha Auvinen
University of Oulu
Lawrence F. Bielak
University of Michigan at Ann Arbor - Department of Epidemiology
Nathan A. Bihlmeyer
Johns Hopkins University - School of Medicine
Jette Bork-Jensen
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Jennifer A. Brody
University of Washington
Archie Campbell
University of Edinburgh
Audrey Y Chu
Harvard University - Brigham and Women's Hospital
Gail Davies
University of Edinburgh
Ayse Demirkan
Erasmus University Rotterdam (EUR) - Department of Epidemiology
James S. Floyd
University of Washington
Franco Giulianini
Harvard University - Brigham and Women's Hospital
Xiuqing Guo
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Stefan Gustafsson
Uppsala University - Clinical Epidemiology Unit
Benoit Hastoy
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Anne U. Jackson
University of Michigan at Ann Arbor
Johanna Jakobsdottir
Icelandic Heart Association
Marjo-Riitta Järvelin
University of Oulu
Richard A. Jensen
University of Washington
Stavroula Kanoni
Queen Mary University of London - William Harvey Research Institute
Sirkka Keinanen-Kiukaanniemi
University of Oulu - Centre for Life Course Health Research
Jin Li
Stanford University - Division of Cardiovascular Medicine
Man Li
University of Utah
Kurt Lohman
Wake Forest University
Yingchang Lu
Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine
Jian’an Luan
University of Cambridge - MRC Epidemiology Unit
Alisa K. Manning
Harvard University - Massachusetts General Hospital
Jonathan Marten
University of Edinburgh - Medical Research Council Human Genetics Unit
Carola Marzi
Helmholtz Association of German Research Centres - Helmholtz Zentrum München
Karina Meidtner
German Institute of Human Nutrition
Dennis O. Mook-Kanamori
Leiden University
Taulant Muka
Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)
Giorgio Pistis
Cittadella Universitaria
Bram Prins
Wellcome Sanger Institute - Department of Human Genetics
Kenneth M. Rice
University of Washington
Neil Robertson
University of Oxford - Wellcome Trust Centre for Human Genetics
Serena Sanna
Cittadella Universitaria
Yuan Shi
Singapore National Eye Centre - Singapore Eye Research Institute
Albert Vernon Smith
Icelandic Heart Association
Jennifer A. Smith
University of Michigan at Ann Arbor - Department of Epidemiology
Lorraine Southam
Wellcome Sanger Institute - Department of Human Genetics
Heather M. Stringham
University of Michigan at Ann Arbor
Salman M. Tajuddin
National Institutes of Health - Laboratory of Epidemiology and Population Sciences
Vinicius Tragante
Utrecht University
Sander W. van der Laan
University Medical Center (Utrecht)
Helen R. Warren
Queen Mary University of London - William Harvey Research Institute
Jie Yao
UCLA Medical Center
Andrianos M. Yiorkas
Imperial College London
Weihua Zhang
Imperial College London - Department of Epidemiology and Biostatistics
Wei Zhao
University of Michigan at Ann Arbor - Department of Epidemiology
Emma Ahlqvist
Lund University - Diabetes Centre
Mariaelisa Graff
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Heather M. Highland
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Anne E. Justice
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Ken Sin Lo
University of Montreal - Université de Montreal
Eirini Marouli
Queen Mary University of London - William Harvey Research Institute
Carolina Medina-Gomez
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Saima Afaq
Imperial College London - Department of Epidemiology and Biostatistics
Wesam A. Alhejily
Queen Mary University of London - William Harvey Research Institute
Najaf Amin
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Folkert W. Asselbergs
Utrecht University - University Medical Center (Utrecht); Netherlands Heart Institute; University College London
Lori L. Bonnycastle
Government of the United States of America - National Institutes of Health (NIH)
Michiel L. Bots
University Medical Center (Utrecht)
Ivan Brandslund
University of Southern Denmark - Lillebaelt Hospital
Ji Chen
Wellcome Sanger Institute - Department of Human Genetics
Cramer Christensen
University of Southern Denmark - Lillebaelt Hospital
John Danesh
University of Cambridge - Department of Public Health and Primary Care
Renée de Mutsert
Leiden University
Abbas Dehghan
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Tapani Ebeling
Oulu University Hospital
Paul Elliott
Imperial College London - Department of Epidemiology and Biostatistics
EPIC-InterAct Consortium
Independent
Aliki-Eleni Farmaki
Harokopio University
Jessica D. Faul
University of Michigan at Ann Arbor
Paul W. Franks
Lund University - Department of Clinical Sciences
Steve Franks
Imperial College London - Institute of Reproductive and Developmental Biology
Andreas Fritsche
University of Tuebingen - University Hospitals Tübingen
Anette P. Gjesing
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Mark O. Goodarzi
Cedars Sinai Medical Center
Vilmundur Gudnason
Icelandic Heart Association
Göran Hallmans
Umeå University
Tamara B. Harris
Icelandic Heart Association
Karl-Heinz Herzig
University of Oulu - Department of Physiology
Marie-France Hivert
Harvard Medical School
Jan-Håkan Jansson
Umeå University - Department of Public Health and Clinical Medicine
Min A. Jhun
University of Michigan at Ann Arbor - Department of Epidemiology
Torben Beck Jørgensen
University of Copenhagen
Marit E. Jørgensen
Steno Diabetes Center Copenhagen
Pekka Jousilahti
National Institute for Health and Welfare
Eero Kajantie
University of Oulu
Maria Karaleftheri
Echinos Medical Centre
Sharon L.R. Kardia
University of Michigan at Ann Arbor - Department of Epidemiology
Leena Kinnunen
National Institute for Health and Welfare
Heikki A. Koistinena
National Institute for Health and Welfare
Pirjo Komulainen
Kuopio Research Institute of Exercise Medicine
Peter Kovacs
University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases
Johanna Kuusisto
University of Eastern Finland - A.I. Virtanen Institute for Molecular Sciences
Markku Laakso
University of Eastern Finland
Leslie A. Lange
University of Colorado at Denver
Lenore J. Launer
National Institute for Health and Welfare
Jung-Jin Lee
University of Pennsylvania
Aaron Leong
Harvard Medical School
Jaana Lindström
National Institute for Health and Welfare
Jocelyn E. Manning Fox
University of Alberta
Satu Männistö
National Institute for Health and Welfare
Nisa M. Maruthur
Johns Hopkins University
Leena Moilanen
Kuopio University Hospital
Antonella Mulas
Cittadella Universitaria
Mike A. Nalls
National Institutes of Health - Molecular Genetics Section
Matthew Neville
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
James S. Pankow
University of Minnesota - Minneapolis - Division of Epidemiology and Community Health
Alison Pattie
University of Edinburgh
Eva R. B. Petersen
Odense University Hospital
Hannu Puolijoki
South Ostobothnia Central Hospital
Asif Rasheed
Center for Non-Communicable Diseases
Paul Redmond
University of Edinburgh
Frida Renström
Lund University - Department of Clinical Sciences
Michael Roden
Heinrich Heine University Dusseldorf
Danish Saleheen
University of Pennsylvania
Juha Saltevo
Central Finland Central Hospital
Kai Savonen
Kuopio Research Institute of Exercise Medicine
Sylvain P. Sébert
University of Oulu - Centre for Life Course Health Research
Tea Skaaby
Bispebjerg and Frederiksberg Hospitals
Kerrin S. Small
King’s College London - Department of Twin Research and Genetic Epidemiology
Alena Stančáková
University of Eastern Finland
Jakob Stokholm
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)
Konstantin Strauch
Helmholtz Zentrum München Research Center for Environmental Health
E-Shyong Tai
National University of Singapore (NUS) - Department of Medicine
Kent D. Taylor
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Betina H. Thuesen
Bispebjerg and Frederiksberg Hospitals
Anke Tönjes
University of Leipzig
Emmanouil Tsafantakis
Anogia Medical Centre
Tiinamaija Tuomi
Folkhälsan Research Center
Jaakko Tuomilehto
National Institute for Health and Welfare
Understanding Society Scientific Group
Independent
Matti I. Uusitupa
University of Eastern Finland
Marja Vääräsmäki
University of Oulu
Ilonca Vaartjes
University Medical Center (Utrecht)
Magdalena Zoledziewska
Cittadella Universitaria
Goncalo Abecasis
University of Michigan at Ann Arbor
Beverley Balkau
Centre de Recherche en Épidémiologie et Santé des Populations (CESP)
Hans Bisgaard
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)
Alexandra I. Blakemore
Brunel University London
Matthias Blüher
University of Leipzig - Department of Medicine
Heiner Boeing
German Institute of Human Nutrition - Department of Epidemiology
Eric Boerwinkle
University of Texas at Houston - School of Public Health
Klaus Bønnelykke
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)
Erwin P. Bottinger
Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine
Mark J. Caulfield
Queen Mary University of London - William Harvey Research Institute
John C. Chambers
Imperial College London
Daniel I. Chasman
Brigham and Women's Hospital
Ching-Yu Cheng
Singapore National Eye Centre - Singapore Eye Research Institute
Anne Clark
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Francis S. Collins
National Institutes of Health (NIH)
Josef Coresh
Johns Hopkins University
Francesco Cucca
National Research Council (CNR) - Istituto di Ricerca Genetica e Biomedica (IRGB)
Gert J. de Borst
University Medical Center (Utrecht)
Ian J. Deary
University of Edinburgh - School of Philosophy, Psychology and Language Studies
George Dedoussis
Harokopio University
Panos Deloukas
Queen Mary University of London - William Harvey Research Institute
Hester M. den Ruijter
University Medical Center Utrecht - Laboratory for Experimental Cardiology
Josée Dupuis
Boston University - Department of Biostatistics
Michele K. Evans
Government of the United States of America - Laboratory of Epidemiology and Population Sciences
Ele Ferrannini
CNR Institute of Clinical Physiology
Oscar H. Franco
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Harald Grallert
German Center for Diabetes Research; Helmholtz Zentrum München - Institute of Epidemiology (EPI)
Leif Groop
Lund University - Department of Clinical Sciences
Torben Hansen
University of Copenhagen - Faculty of Health and Medical Sciences
Andrew T. Hattersley
University of Exeter - Institute of Biomedical and Clinical Science
Caroline Hayward
University of Edinburgh - MRC Human Genetics Unit
Joel N. Hirschhorn
Harvard University - Department of Pediatrics
M. Arfan Ikram
Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology
Erik Ingelsson
Stanford University - Division of Cardiology
Fredrik Karpe
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Kay-Tee Kaw
University of Cambridge - Department of Public Health and Primary Care
Wieland Kiess
University of Leipzig - Center for Pediatric Research
Jaspal S. Kooner
Imperial College London
Antje Körner
University of Leipzig
Timo Lakka
University of Eastern Finland - Institute of Biomedicine
Claudia Langenberg
University of Cambridge - MRC Epidemiology Unit; Government of the United Kingdom - Public Health England; The Francis Crick Institute
Lars Lind
Uppsala University - Department of Medical Sciences
Cecilia M. Lindgren
Massachusetts Institute of Technology and Harvard University - Broad Institute
Allan Linneberg
Bispebjerg and Frederiksberg Hospitals
Leonard Lipovich
Wayne State University
Ching-Ti Liu
Boston University - Department of Biostatistics
Jun Liu
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Yongmei Liu
Wake Forest University
Ruth J. F. Loos
Mount Sinai Health System - Charles Bronfman Institute for Personalized Medicine
Patrick E. MacDonald
University of Alberta
Karen L. Mohlke
University of North Carolina (UNC) at Chapel Hill - Department of Genetics
Andrew D. Morris
University of Edinburgh - Usher Institute of Population Health Sciences and Informatics
Patricia B. Munroe
Queen Mary University of London - William Harvey Research Institute
Alison Murray
University of Aberdeen
Sandosh Padmanabhan
University of Glasgow
Colin N. A. Palmer
University of Dundee - Division of Population Health and Genomics
Gerard Pasterkamp
University Medical Center (Utrecht)
Oluf Pedersen
University of Copenhagen - Faculty of Health and Medical Sciences
Patricia A. Peyser
University of Michigan at Ann Arbor - Department of Epidemiology
Ozren Polasek
University of Split
David Porteous
University of Edinburgh
Michael A. Province
Washington University in St. Louis
Bruce M. Psaty
University of Washington
Rainer Rauramaa
Kuopio Research Institute of Exercise Medicine
Paul M. Ridker
Brigham and Women's Hospital
Olov Rolandsson
Umeå University
Patrik Rorsman
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Frits Rosendaal
Leiden University - Leiden University Medical Center (LUMC)
Igor Rudan
University of Edinburgh - Usher Institute of Population Health Sciences and Informatics
Veikko Salomaa
National Institute for Health and Welfare
Matthias B. Schulze
German Institute of Human Nutrition
Robert Sladek
McGill University - Department of Medicine
Blair H. Smith
University of Dundee - Division of Population Health and Genomics
Timothy D. Spector
King's College London, Department of Twin Research and Genetic Epidemiology
John M. Starr
University of Edinburgh
Michael Stumvoll
University of Leipzig
Cornelia M. van Duijn
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Mark Walker
University of Newcastle - Institute of Cellular Medicine
Nick J. Wareham
University of Cambridge - MRC Epidemiology Unit
David R. Weir
University of Michigan at Ann Arbor
James G. Wilson
University of Mississippi - Medical Center
Tien Yin Wong
Singapore National Eye Centre - Singapore Eye Research Institute
Eleftheria Zeggini
Wellcome Trust Sanger Institute
Alan B. Zonderman
Government of the United States of America - Laboratory of Epidemiology and Population Sciences
Jerome I. Rotter
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Andrew P. Morris
University of Liverpool - Department of Biostatistics
Michael Boehnke
University of Michigan at Ann Arbor
Jose Florez
Massachusetts General Hospital
Mark I. McCarthy
University of Oxford - Wellcome Centre for Human Genetics; University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
James B. Meigs
Massachusetts General Hospital
Anubha Mahajan
University of Oxford - Wellcome Trust Centre for Human Genetics
Robert A. Scott
University of Cambridge - MRC Epidemiology Unit
Anna L. Gloyn
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Ines Barroso
Wellcome Trust Sanger Institute
Abstract
Metabolic dysregulation in multiple tissues influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits we investigated associations of exome-array variants in up to 144,060 nondiabetic individuals of multiple ancestries. Single-variant analyses identified 21 novel coding variant associations (18 loci), whilst gene-based tests revealed novel signals at TF (HbA1c) and G6PC [(Fasting Glucose (FG), Fasting Insulin (FI)]. Pathway and tissue enrichment analyses of trait-associated transcripts confirmed the importance of liver and kidney for FI and islets for FG, implicated adipose tissue in FI and gut in 2hGlu, and a role for the non-endocrine pancreas in glucose homeostasis. Functional studies demonstrated that the liver-enriched G6PC and the islet-specific G6PC2 were driven by multiple rare variants, with G6PC2 including two alleles within the same codon with divergent effects on glucose levels. Our findings highlight the value of integrating genomic and functional data to maximize biological inference.
Keywords: genetics, Genomics, glycemic traits, type 2 diabetes, tissue, pathways, effector transcript
Suggested Citation: Suggested Citation
Natasha Ng (Contact Author)
University of Oxford
Sara M. Willems
University of Cambridge
Juan Fernandez
University of Oxford - Wellcome Centre for Human Genetics
Oxford, OX3 7BN
United Kingdom
Rebecca S. Fine
Harvard University - Department of Genetics
Boston, MA 02115
United States
Eleanor Wheeler
Wellcome Trust Sanger Institute
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
Jennifer Wessel
Indiana University - Department of Epidemiology and Biostatistics
Bloomington, ID
United States
Hidetoshi Kitajima
University of Oxford - Wellcome Centre for Human Genetics
Oxford, OX3 7BN
United Kingdom
Gaëlle Marenne
Wellcome Trust Sanger Institute
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
Jana K. Rundle
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
Xueling Sim
National University of Singapore (NUS) - Saw Swee Hock School of Public Health
12 Science Drive 2
#10-01
117549
Singapore
Hanieh Yeghootkar
University of Exeter - Medical School
Exeter
United Kingdom
Nicola L. Beer
University of Oxford
Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom
Anne Raimondo
University of Oxford
Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom
Andrei I. Tarasov
University of Oxford
Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom
Soren K. Thomsen
University of Oxford
Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom
Martijn Van de Bunt
University of Oxford - Wellcome Centre for Human Genetics
Oxford, OX3 7BN
United Kingdom
Shuai Wang
Boston University - Department of Biostatistics
Boston, MA
United States
Sai Chen
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Yuning Chen
Boston University - Department of Biostatistics
Boston, MA
United States
Yii-Der Ida Chen
UCLA Medical Center
Los Angeles, CA
United States
Hugoline G. De Haan
Leiden University - Leiden University Medical Center (LUMC)
Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands
Niels Grarup
University of Copenhagen - Novo Nordisk Foundation Center for Protein Research
Nørregade 10
Copenhagen, København DK-1165
Denmark
Ruifang Li-Gao
Leiden University - Leiden University Medical Center (LUMC)
Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands
Tibor V. Varga
Lund University
Box 117
Lund, SC Skane S221 00
Sweden
Jennifer L Asimit
Wellcome Genome Campus - Wellcome Trust Sanger Institute
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
Wellcome Genome Campus - Wellcome Trust Sanger Institute
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
Shuang Feng
University of Michigan at Ann Arbor - School of Public Health
1415 Washington Heights
Ann Arbor, MI 48109-2029
United States
Rona J. Strawbridge
University of Glasgow - College of Medical, Veterinary & Life Sciences
Wolfson Medical School Building
University Avenue
Glasgow, Scotland G12 8QQ
United Kingdom
Erica L. Kleinbrink
Wayne State University
Department of Physiology, Wayne State University
Detroit, MI 48202
United States
Tarunveer S. Ahluwalia
University of Copenhagen - Herlev Hospital
Herlev Ringvej 75
DK-2730 Herlev
Denmark
Ping An
Washington University in St. Louis - Department of Genetics
4515 McKinley Ave
St. Louis, WA 63110
United States
Emil V. Appel
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Blegdamsvej 3B
Copenhagen, DK-2200
Denmark
Dan E Arking
Johns Hopkins University - School of Medicine
733 North Broadway
Suite G-49
Baltimore, MD 21205-2196
United States
Juha Auvinen
University of Oulu
P.O. Box 4600
Oulu FIN-90014, 90570
Finland
Lawrence F. Bielak
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Nathan A. Bihlmeyer
Johns Hopkins University - School of Medicine
733 North Broadway
Suite G-49
Baltimore, MD 21205-2196
United States
Jette Bork-Jensen
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Blegdamsvej 3B
Copenhagen, DK-2200
Denmark
Jennifer A. Brody
University of Washington
Seattle, WA 98195
United States
Archie Campbell
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Audrey Y Chu
Harvard University - Brigham and Women's Hospital
75 Francis St.
Boston, MA 02115
United States
Gail Davies
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Ayse Demirkan
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
James S. Floyd
University of Washington
Seattle, WA 98195
United States
Franco Giulianini
Harvard University - Brigham and Women's Hospital
75 Francis St.
Boston, MA 02115
United States
Xiuqing Guo
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Santa Monica, CA
United States
Stefan Gustafsson
Uppsala University - Clinical Epidemiology Unit
Uppsala
Sweden
Benoit Hastoy
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
Anne U. Jackson
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Johanna Jakobsdottir
Icelandic Heart Association
Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland
Marjo-Riitta Järvelin
University of Oulu
P.O. Box 4600
Oulu FIN-90014, 90570
Finland
Richard A. Jensen
University of Washington
Seattle, WA 98195
United States
Stavroula Kanoni
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Sirkka Keinanen-Kiukaanniemi
University of Oulu - Centre for Life Course Health Research
Finland
Jin Li
Stanford University - Division of Cardiovascular Medicine
Stanford, CA
United States
Man Li
University of Utah
1645 E. Campus Center
Salt Lake City, UT 84112
United States
Kurt Lohman
Wake Forest University
2601 Wake Forest Road
Winston-Salem, NC 27109
United States
Yingchang Lu
Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine
1468 Madison Avenue
New York, NY 10029
United States
Jian’an Luan
University of Cambridge - MRC Epidemiology Unit
United Kingdom
Alisa K. Manning
Harvard University - Massachusetts General Hospital
55 Fruit Street Boston
Boston, MA 02114
United States
Jonathan Marten
University of Edinburgh - Medical Research Council Human Genetics Unit
Edinburgh
United Kingdom
Carola Marzi
Helmholtz Association of German Research Centres - Helmholtz Zentrum München
Ingolstaedter Landstraße 1
Neuherberg, Bavaria D-85764
Germany
Karina Meidtner
German Institute of Human Nutrition
Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany
Dennis O. Mook-Kanamori
Leiden University
Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands
Taulant Muka
Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)
Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands
Giorgio Pistis
Cittadella Universitaria
Monserrato, 09042
Italy
Bram Prins
Wellcome Sanger Institute - Department of Human Genetics
Hinxton, Cambridge
United Kingdom
Kenneth M. Rice
University of Washington
Seattle, WA 98195
United States
Neil Robertson
University of Oxford - Wellcome Trust Centre for Human Genetics
Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom
Serena Sanna
Cittadella Universitaria
Monserrato, 09042
Italy
Yuan Shi
Singapore National Eye Centre - Singapore Eye Research Institute
168751
Singapore
Albert Vernon Smith
Icelandic Heart Association
Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland
Jennifer A. Smith
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Lorraine Southam
Wellcome Sanger Institute - Department of Human Genetics
Hinxton, Cambridge
United Kingdom
Heather M. Stringham
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Salman M. Tajuddin
National Institutes of Health - Laboratory of Epidemiology and Population Sciences
United States
Vinicius Tragante
Utrecht University
Vredenburg 138
Utrecht, 3511 BG
Netherlands
Sander W. Van der Laan
University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Helen R. Warren
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Jie Yao
UCLA Medical Center
Santa Monica, CA
United States
Andrianos M. Yiorkas
Imperial College London
South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom
Weihua Zhang
Imperial College London - Department of Epidemiology and Biostatistics
London
United Kingdom
Wei Zhao
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Emma Ahlqvist
Lund University - Diabetes Centre
Malmö
Sweden
Mariaelisa Graff
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Chapel Hill, NC 27599
United States
Heather M. Highland
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Chapel Hill, NC 27599
United States
Anne E. Justice
University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology
Chapel Hill, NC 27599
United States
Ken Sin Lo
University of Montreal - Université de Montreal
H3T 1J4
2350 Édouard Montpetit 11139
Montréal, Quebec H3T 1J4
Canada
Eirini Marouli
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Carolina Medina-Gomez
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
Saima Afaq
Imperial College London - Department of Epidemiology and Biostatistics
London
United Kingdom
Wesam A. Alhejily
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Najaf Amin
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
Folkert W. Asselbergs
Utrecht University - University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Netherlands Heart Institute
Netherlands
University College London
Gower Street
London, WC1E 6BT
United Kingdom
Lori L. Bonnycastle
Government of the United States of America - National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, MD 20892
United States
Michiel L. Bots
University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Ivan Brandslund
University of Southern Denmark - Lillebaelt Hospital
Vejle
Denmark
Ji Chen
Wellcome Sanger Institute - Department of Human Genetics
Hinxton, Cambridge
United Kingdom
Cramer Christensen
University of Southern Denmark - Lillebaelt Hospital
Vejle
Denmark
John Danesh
University of Cambridge - Department of Public Health and Primary Care
Cambridge
United Kingdom
Renée De Mutsert
Leiden University
Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands
Abbas Dehghan
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
Tapani Ebeling
Oulu University Hospital
Oulu
United States
Paul Elliott
Imperial College London - Department of Epidemiology and Biostatistics ( email )
St Mary's Campus
Norfolk Pl, Paddington
London, W2 1QN
United Kingdom
EPIC-InterAct Consortium
Independent
Aliki-Eleni Farmaki
Harokopio University
Greece
Jessica D. Faul
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Paul W. Franks
Lund University - Department of Clinical Sciences
Sweden
Steve Franks
Imperial College London - Institute of Reproductive and Developmental Biology
London
United Kingdom
Andreas Fritsche
University of Tuebingen - University Hospitals Tübingen
Geschwister-Scholl-Platz
Tübingen, 72074
Germany
Anette P. Gjesing
University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
Blegdamsvej 3B
Copenhagen, DK-2200
Denmark
Mark O. Goodarzi
Cedars Sinai Medical Center
8700 Beverly Blvd.
Los Angeles, CA 90048
United States
Vilmundur Gudnason
Icelandic Heart Association
Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland
Göran Hallmans
Umeå University
Samhallsvetarhuset, Plan 2
Umea University
Umeå, SE 901 87
Sweden
Tamara B. Harris
Icelandic Heart Association
Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland
Karl-Heinz Herzig
University of Oulu - Department of Physiology ( email )
Oulu
Finland
Marie-France Hivert
Harvard Medical School
1875 Cambridge Street
Cambridge, MA 02138
United States
Jan-Håkan Jansson
Umeå University - Department of Public Health and Clinical Medicine
SE-901 87
Umeå
Sweden
Min A. Jhun
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Torben Beck Jørgensen
University of Copenhagen ( email )
Nørregade 10
Copenhagen, København DK-1165
Denmark
Marit E. Jørgensen
Steno Diabetes Center Copenhagen
Denmark
Pekka Jousilahti
National Institute for Health and Welfare
Helsinki
Finland
Eero Kajantie
University of Oulu
P.O. Box 4600
Oulu FIN-90014, 90570
Finland
Maria Karaleftheri
Echinos Medical Centre
Echinos
Greece
Sharon L.R. Kardia
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Leena Kinnunen
National Institute for Health and Welfare
Helsinki
Finland
Heikki A. Koistinena
National Institute for Health and Welfare
Helsinki
Finland
Pirjo Komulainen
Kuopio Research Institute of Exercise Medicine
Kuopio, 70100
Finland
Peter Kovacs
University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases
Germany
Leslie A. Lange
University of Colorado at Denver
Box 173364
1250 14th Street
Denver, CO 80217
United States
Lenore J. Launer
National Institute for Health and Welfare
Helsinki
Finland
Jung-Jin Lee
University of Pennsylvania
Philadelphia, PA 19104
United States
Aaron Leong
Harvard Medical School
25 Shattuck St
Boston, MA 02115
United States
Jaana Lindström
National Institute for Health and Welfare
Helsinki
Finland
Jocelyn E. Manning Fox
University of Alberta
Edmonton, Alberta T6G 2R3
Canada
Satu Männistö
National Institute for Health and Welfare
Helsinki
Finland
Nisa M. Maruthur
Johns Hopkins University
Baltimore, MD 20036-1984
United States
Leena Moilanen
Kuopio University Hospital
Kuopio, 70210
Finland
Antonella Mulas
Cittadella Universitaria
Monserrato, 09042
Italy
Mike A. Nalls
National Institutes of Health - Molecular Genetics Section
Bethseda, MD 20892
United States
Matthew Neville
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
James S. Pankow
University of Minnesota - Minneapolis - Division of Epidemiology and Community Health
1300 S. 2nd St.
300 West Bank Office Building
Minneapolis, MN 55454
United States
Alison Pattie
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Eva R. B. Petersen
Odense University Hospital
J. B. Winsløws Vej 4
Odense
Denmark
Hannu Puolijoki
South Ostobothnia Central Hospital
Seinajoki, 60220
Finland
Asif Rasheed
Center for Non-Communicable Diseases
Karachi
Pakistan
Paul Redmond
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Frida Renström
Lund University - Department of Clinical Sciences
Sweden
Michael Roden
Heinrich Heine University Dusseldorf
Universitätsstrasse 1
Duesseldorf, DE NRW 40225
Germany
Danish Saleheen
University of Pennsylvania
Philadelphia, PA 19104
United States
Juha Saltevo
Central Finland Central Hospital
Jyvaskyla, 40620
Finland
Kai Savonen
Kuopio Research Institute of Exercise Medicine
Kuopio, 70100
Finland
Sylvain P. Sébert
University of Oulu - Centre for Life Course Health Research ( email )
Finland
+358 503440842 (Phone)
Tea Skaaby
Bispebjerg and Frederiksberg Hospitals
Bispebjerg Bakke 23
2400 København
Denmark
Kerrin S. Small
King’s College London - Department of Twin Research and Genetic Epidemiology
London
United Kingdom
Jakob Stokholm
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)
Ledreborg Alle 34
Gentofte, 2820
Denmark
Konstantin Strauch
Helmholtz Zentrum München Research Center for Environmental Health
Ingolstaedter Landstraße 1
Neuherberg, Bavaria D-85764
Germany
E-Shyong Tai
National University of Singapore (NUS) - Department of Medicine
Singapore
Kent D. Taylor
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Santa Monica, CA
United States
Betina H. Thuesen
Bispebjerg and Frederiksberg Hospitals
Bispebjerg Bakke 23
2400 København
Denmark
Anke Tönjes
University of Leipzig
Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany
Emmanouil Tsafantakis
Anogia Medical Centre
Anogia
Greece
Tiinamaija Tuomi
Folkhälsan Research Center
Finland
Jaakko Tuomilehto
National Institute for Health and Welfare
Helsinki
Finland
Understanding Society Scientific Group
Independent
Marja Vääräsmäki
University of Oulu
P.O. Box 4600
Oulu FIN-90014, 90570
Finland
Ilonca Vaartjes
University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Magdalena Zoledziewska
Cittadella Universitaria
Monserrato, 09042
Italy
Goncalo Abecasis
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Beverley Balkau
Centre de Recherche en Épidémiologie et Santé des Populations (CESP)
France
Hans Bisgaard
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC) ( email )
Ledreborg Alle 34
Gentofte, 2820
Denmark
Alexandra I. Blakemore
Brunel University London
Kingston Lane
Uxbridge, Middlesex UB8 3PH
United Kingdom
Matthias Blüher
University of Leipzig - Department of Medicine
Germany
Heiner Boeing
German Institute of Human Nutrition - Department of Epidemiology ( email )
Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany
Eric Boerwinkle
University of Texas at Houston - School of Public Health
1200 Pressler Street
Houston, TX 77030
United States
Klaus Bønnelykke
University of Copenhagen - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)
Ledreborg Alle 34
Gentofte, 2820
Denmark
Erwin P. Bottinger
Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine
1468 Madison Avenue
New York, NY 10029
United States
Mark J. Caulfield
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
John C. Chambers
Imperial College London
South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom
Daniel I. Chasman
Brigham and Women's Hospital
75 Francis St.
Boston, MA 02115
United States
Ching-Yu Cheng
Singapore National Eye Centre - Singapore Eye Research Institute ( email )
168751
Singapore
Anne Clark
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
Francis S. Collins
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, MD 20892
United States
Josef Coresh
Johns Hopkins University
Baltimore, MD 20036-1984
United States
Francesco Cucca
National Research Council (CNR) - Istituto di Ricerca Genetica e Biomedica (IRGB)
SS 554 bivio per Sestu Km 4,500
Monserrato, 09042
Italy
Gert J. De Borst
University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Ian J. Deary
University of Edinburgh - School of Philosophy, Psychology and Language Studies ( email )
Teviot Place
Edinbrurgh, EH8 9AG
United Kingdom
George Dedoussis
Harokopio University
Greece
Panos Deloukas
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Hester M. Den Ruijter
University Medical Center Utrecht - Laboratory for Experimental Cardiology
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Josée Dupuis
Boston University - Department of Biostatistics
Boston, MA
United States
Michele K. Evans
Government of the United States of America - Laboratory of Epidemiology and Population Sciences
United States
Ele Ferrannini
CNR Institute of Clinical Physiology
Lungarno Pacinotti, 43
Pisa PI, 56126
Italy
Oscar H. Franco
Erasmus University Rotterdam (EUR) - Department of Epidemiology ( email )
Rotterdam
Netherlands
Harald Grallert
German Center for Diabetes Research
85764 Neuherberg
Germany
Helmholtz Zentrum München - Institute of Epidemiology (EPI)
Neuherberg, Bavaria
Germany
Leif Groop
Lund University - Department of Clinical Sciences
Sweden
Torben Hansen
University of Copenhagen - Faculty of Health and Medical Sciences
Blegdamsvej 3B
Copenhagen, DK-2200
Denmark
Andrew T. Hattersley
University of Exeter - Institute of Biomedical and Clinical Science
Exeter
United Kingdom
Caroline Hayward
University of Edinburgh - MRC Human Genetics Unit
Edinburgh
United Kingdom
Joel N. Hirschhorn
Harvard University - Department of Pediatrics
Boston, MA
United States
M. Arfan Ikram
Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology
Rotterdam
Netherlands
Erik Ingelsson
Stanford University - Division of Cardiology
Stanford, CA
United States
Fredrik Karpe
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
Kay-Tee Kaw
University of Cambridge - Department of Public Health and Primary Care
Cambridge
United Kingdom
Wieland Kiess
University of Leipzig - Center for Pediatric Research
Leipzig
Germany
Jaspal S. Kooner
Imperial College London
South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom
Antje Körner
University of Leipzig
Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany
Timo Lakka
University of Eastern Finland - Institute of Biomedicine
PO Box 111
Joensuu, 80100
Finland
Claudia Langenberg
University of Cambridge - MRC Epidemiology Unit
United Kingdom
Government of the United Kingdom - Public Health England
Wellington House
133-155 Waterloo Road
London, SE1 8UG
United Kingdom
The Francis Crick Institute
1 Midland Road
London, NW1 1AT
United Kingdom
Lars Lind
Uppsala University - Department of Medical Sciences
Uppsala
Sweden
Cecilia M. Lindgren
Massachusetts Institute of Technology and Harvard University - Broad Institute
415 Main Street
Cambridge, MA 02142
United States
Allan Linneberg
Bispebjerg and Frederiksberg Hospitals
Bispebjerg Bakke 23
2400 København
Denmark
Leonard Lipovich
Wayne State University
Department of Physiology, Wayne State University
Detroit, MI 48202
United States
Ching-Ti Liu
Boston University - Department of Biostatistics
Boston, MA
United States
Jun Liu
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
Yongmei Liu
Wake Forest University
2601 Wake Forest Road
Winston-Salem, NC 27109
United States
Ruth J. F. Loos
Mount Sinai Health System - Charles Bronfman Institute for Personalized Medicine
1468 Madison Avenue
New York, NY 10029
United States
Patrick E. MacDonald
University of Alberta
Edmonton, Alberta T6G 2R3
Canada
Karen L. Mohlke
University of North Carolina (UNC) at Chapel Hill - Department of Genetics
102 Ridge Road
Chapel Hill, NC 27514
United States
Andrew D. Morris
University of Edinburgh - Usher Institute of Population Health Sciences and Informatics
Teviot Place
Edinburgh, EH8 9AG
United Kingdom
Patricia B. Munroe
Queen Mary University of London - William Harvey Research Institute
Charterhouse Square
London
United Kingdom
Alison Murray
University of Aberdeen
Dunbar Street
Aberdeen, Scotland AB24 3QY
United Kingdom
Sandosh Padmanabhan
University of Glasgow
Adam Smith Business School
Glasgow, Scotland G12 8LE
United Kingdom
Colin N. A. Palmer
University of Dundee - Division of Population Health and Genomics ( email )
Dundee
United Kingdom
Gerard Pasterkamp
University Medical Center (Utrecht)
6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands
Oluf Pedersen
University of Copenhagen - Faculty of Health and Medical Sciences
Blegdamsvej 3B
Copenhagen, DK-2200
Denmark
Patricia A. Peyser
University of Michigan at Ann Arbor - Department of Epidemiology
Ann Arbor, MI
United States
Ozren Polasek
University of Split
Livanjska ulica 5
Split, 21000
Croatia
David Porteous
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Michael A. Province
Washington University in St. Louis
One Brookings Drive
Campus Box 1208
Saint Louis, MO MO 63130-4899
United States
Bruce M. Psaty
University of Washington
Seattle, WA 98195
United States
Rainer Rauramaa
Kuopio Research Institute of Exercise Medicine
Kuopio, 70100
Finland
Paul M. Ridker
Brigham and Women's Hospital
75 Francis St.
Boston, MA 02115
United States
Olov Rolandsson
Umeå University
Samhallsvetarhuset, Plan 2
Umea University
Umeå, SE 901 87
Sweden
Patrik Rorsman
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
Frits Rosendaal
Leiden University - Leiden University Medical Center (LUMC)
Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands
Igor Rudan
University of Edinburgh - Usher Institute of Population Health Sciences and Informatics
Teviot Place
Edinburgh, EH8 9AG
United Kingdom
Veikko Salomaa
National Institute for Health and Welfare
Helsinki
Finland
Matthias B. Schulze
German Institute of Human Nutrition
Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany
Robert Sladek
McGill University - Department of Medicine
Montreal, Quebec
Canada
Blair H. Smith
University of Dundee - Division of Population Health and Genomics
Dundee
United Kingdom
Timothy D. Spector
King's College London, Department of Twin Research and Genetic Epidemiology
London
United Kingdom
John M. Starr
University of Edinburgh
Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom
Michael Stumvoll
University of Leipzig
Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany
Cornelia M. Van Duijn
Erasmus University Rotterdam (EUR) - Department of Epidemiology
Rotterdam
Netherlands
Mark Walker
University of Newcastle - Institute of Cellular Medicine
Framlington Place
United Kingdom
Nick J. Wareham
University of Cambridge - MRC Epidemiology Unit
United Kingdom
David R. Weir
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
James G. Wilson
University of Mississippi - Medical Center
Jackson, MS 39216-4505
United States
Tien Yin Wong
Singapore National Eye Centre - Singapore Eye Research Institute ( email )
168751
Singapore
Eleftheria Zeggini
Wellcome Trust Sanger Institute
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
Alan B. Zonderman
Government of the United States of America - Laboratory of Epidemiology and Population Sciences
United States
Jerome I. Rotter
UCLA Medical Center - The Institute for Translational Genomics and Population Sciences
Santa Monica, CA
United States
Andrew P. Morris
University of Liverpool - Department of Biostatistics
United Kingdom
Michael Boehnke
University of Michigan at Ann Arbor
500 S. State Street
Ann Arbor, MI 48109
United States
Jose Florez
Massachusetts General Hospital
55 Fruit Street Boston
Boston, MA 02114
United States
Mark I. McCarthy
University of Oxford - Wellcome Centre for Human Genetics
Oxford, OX3 7BN
United Kingdom
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, OX3 7LE
United Kingdom
James B. Meigs
Massachusetts General Hospital
55 Fruit Street Boston
Boston, MA 02114
United States
Anubha Mahajan
University of Oxford - Wellcome Trust Centre for Human Genetics
Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom
Robert A. Scott
University of Cambridge - MRC Epidemiology Unit
United Kingdom
Anna L. Gloyn
University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism ( email )
Oxford, OX3 7LE
United Kingdom
Ines Barroso
Wellcome Trust Sanger Institute ( email )
Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom
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