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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

99 Pages Posted: 1 Nov 2019 Publication Status: Review Complete

See all articles by Natasha Ng

Natasha Ng

University of Oxford

Sara M. Willems

University of Cambridge

Juan Fernandez

University of Oxford - Wellcome Centre for Human Genetics

Rebecca S. Fine

Harvard University - Department of Genetics

Eleanor Wheeler

Wellcome Trust Sanger Institute

Jennifer Wessel

Indiana University - Department of Epidemiology and Biostatistics

Hidetoshi Kitajima

University of Oxford - Wellcome Centre for Human Genetics

Gaëlle Marenne

Wellcome Trust Sanger Institute

Jana K. Rundle

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Xueling Sim

National University of Singapore (NUS) - Saw Swee Hock School of Public Health

Hanieh Yeghootkar

University of Exeter - Medical School

Nicola L. Beer

University of Oxford

Anne Raimondo

University of Oxford

Andrei I. Tarasov

University of Oxford

Soren K. Thomsen

University of Oxford

Martijn van de Bunt

University of Oxford - Wellcome Centre for Human Genetics

Shuai Wang

Boston University - Department of Biostatistics

Sai Chen

University of Michigan at Ann Arbor

Yuning Chen

Boston University - Department of Biostatistics

Yii-Der Ida Chen

UCLA Medical Center

Hugoline G. de Haan

Leiden University - Medical Center (LUMC)

Niels Grarup

University of Copenhagen - Novo Nordisk Foundation Center for Protein Research

Ruifang Li-Gao

Leiden University - Medical Center (LUMC)

Tibor V. Varga

Lund University

Jennifer L Asimit

Wellcome Genome Campus - Wellcome Trust Sanger Institute; Wellcome Genome Campus - Wellcome Trust Sanger Institute

Shuang Feng

University of Michigan at Ann Arbor - School of Public Health

Rona J. Strawbridge

University of Glasgow - College of Medical, Veterinary & Life Sciences

Erica L. Kleinbrink

Wayne State University

Tarunveer S. Ahluwalia

University of Copenhagen - Herlev Hospital

Ping An

Washington University in St. Louis - Department of Genetics

Emil V. Appel

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Dan E Arking

Johns Hopkins University - School of Medicine

Juha Auvinen

University of Oulu

Lawrence F. Bielak

University of Michigan at Ann Arbor - Department of Epidemiology

Nathan A. Bihlmeyer

Johns Hopkins University - School of Medicine

Jette Bork-Jensen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Jennifer A. Brody

University of Washington

Archie Campbell

University of Edinburgh

Audrey Y Chu

Harvard University - Brigham and Women's Hospital

Gail Davies

University of Edinburgh

Ayse Demirkan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

James S. Floyd

University of Washington

Franco Giulianini

Harvard University - Brigham and Women's Hospital

Xiuqing Guo

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Stefan Gustafsson

Uppsala University

Benoit Hastoy

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Anne U. Jackson

University of Michigan at Ann Arbor

Johanna Jakobsdottir

Icelandic Heart Association

Marjo-Riitta Järvelin

University of Oulu

Richard A. Jensen

University of Washington

Stavroula Kanoni

Queen Mary University of London - William Harvey Research Institute

Sirkka Keinanen-Kiukaanniemi

University of Oulu - Centre for Life Course Health Research

Jin Li

Stanford University - Division of Cardiovascular Medicine

Man Li

University of Utah

Kurt Lohman

Wake Forest University

Yingchang Lu

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

Jian’an Luan

University of Cambridge - MRC Epidemiology Unit

Alisa K. Manning

Harvard University - Massachusetts General Hospital

Jonathan Marten

University of Edinburgh - Medical Research Council Human Genetics Unit

Carola Marzi

Helmholtz Association of German Research Centres - Helmholtz Zentrum München

Karina Meidtner

German Institute of Human Nutrition

Dennis O. Mook-Kanamori

Leiden University

Taulant Muka

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Giorgio Pistis

Cittadella Universitaria

Bram Prins

Wellcome Sanger Institute - Department of Human Genetics

Kenneth M. Rice

University of Washington

Neil Robertson

University of Oxford - Wellcome Trust Centre for Human Genetics

Serena Sanna

Cittadella Universitaria

Yuan Shi

Singapore National Eye Centre - Singapore Eye Research Institute

Albert Vernon Smith

Icelandic Heart Association

Jennifer A. Smith

University of Michigan at Ann Arbor - Department of Epidemiology

Lorraine Southam

Wellcome Sanger Institute - Department of Human Genetics

Heather M. Stringham

University of Michigan at Ann Arbor

Salman M. Tajuddin

National Institutes of Health - Laboratory of Epidemiology and Population Sciences

Vinicius Tragante

Utrecht University

Sander W. van der Laan

University Medical Center (Utrecht)

Helen R. Warren

Queen Mary University of London - William Harvey Research Institute

Jie Yao

UCLA Medical Center

Andrianos M. Yiorkas

Imperial College London

Weihua Zhang

Imperial College London - Department of Epidemiology and Biostatistics

Wei Zhao

University of Michigan at Ann Arbor - Department of Epidemiology

Emma Ahlqvist

Lund University - Diabetes Centre

Mariaelisa Graff

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Heather M. Highland

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Anne E. Justice

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Ken Sin Lo

University of Montreal - Université de Montreal

Eirini Marouli

Queen Mary University of London - William Harvey Research Institute

Carolina Medina-Gomez

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Saima Afaq

Imperial College London - Department of Epidemiology and Biostatistics

Wesam A. Alhejily

Queen Mary University of London - William Harvey Research Institute

Najaf Amin

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Folkert W. Asselbergs

Utrecht University - University Medical Center (Utrecht); Netherlands Heart Institute; University College London

Lori L. Bonnycastle

Government of the United States of America - National Institutes of Health (NIH)

Michiel L. Bots

University Medical Center (Utrecht)

Ivan Brandslund

Lillebaelt Hospital

Ji Chen

Wellcome Sanger Institute - Department of Human Genetics

Cramer Christensen

Lillebaelt Hospital

John Danesh

University of Cambridge - Department of Public Health and Primary Care

Renée de Mutsert

Leiden University

Abbas Dehghan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Tapani Ebeling

Oulu University Hospital

Paul Elliott

Imperial College London - Department of Epidemiology and Biostatistics

EPIC-InterAct Consortium

Aliki-Eleni Farmaki

Harokopio University

Jessica D. Faul

University of Michigan at Ann Arbor

Paul W. Franks

Lund University - Department of Clinical Sciences

Steve Franks

Imperial College London - Institute of Reproductive and Developmental Biology

Andreas Fritsche

University of Tuebingen - University Hospitals Tübingen

Anette P. Gjesing

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Mark O. Goodarzi

Cedars Sinai Medical Center

Vilmundur Gudnason

Icelandic Heart Association

Göran Hallmans

University of Umea

Tamara B. Harris

Icelandic Heart Association

Karl-Heinz Herzig

University of Oulu - Department of Physiology

Marie-France Hivert

Harvard Medical School

Jan-Håkan Jansson

University of Umea - Department of Public Health and Clinical Medicine

Min A. Jhun

University of Michigan at Ann Arbor - Department of Epidemiology

Torben Beck Jørgensen

University of Copenhagen

Marit E. Jørgensen

Steno Diabetes Center Copenhagen

Pekka Jousilahti

National Institute for Health and Welfare

Eero Kajantie

University of Oulu

Maria Karaleftheri

Echinos Medical Centre

Sharon L.R. Kardia

University of Michigan at Ann Arbor - Department of Epidemiology

Leena Kinnunen

National Institute for Health and Welfare

Heikki A. Koistinena

National Institute for Health and Welfare

Pirjo Komulainen

Kuopio Research Institute of Exercise Medicine

Peter Kovacs

University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases

Johanna Kuusisto

University of Eastern Finland

Markku Laakso

University of Eastern Finland

Leslie A. Lange

University of Colorado at Denver

Lenore J. Launer

National Institute for Health and Welfare

Jung-Jin Lee

University of Pennsylvania

Aaron Leong

Harvard Medical School

Jaana Lindström

National Institute for Health and Welfare

Jocelyn E. Manning Fox

University of Alberta

Satu Männistö

National Institute for Health and Welfare

Nisa M. Maruthur

Johns Hopkins University

Leena Moilanen

Kuopio University Hospital

Antonella Mulas

Cittadella Universitaria

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Matthew Neville

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

James S. Pankow

University of Minnesota - Minneapolis - Division of Epidemiology and Community Health

Alison Pattie

University of Edinburgh

Eva R. B. Petersen

Odense University Hospital

Hannu Puolijoki

South Ostobothnia Central Hospital

Asif Rasheed

Center for Non-Communicable Diseases

Paul Redmond

University of Edinburgh

Frida Renström

Lund University - Department of Clinical Sciences

Michael Roden

Heinrich Heine University Dusseldorf

Danish Saleheen

University of Pennsylvania

Juha Saltevo

Central Finland Central Hospital

Kai Savonen

Kuopio Research Institute of Exercise Medicine

Sylvain P. Sébert

University of Oulu - Centre for Life Course Health Research

Tea Skaaby

Bispebjerg and Frederiksberg Hospitals

Kerrin S. Small

University of London - Department of Twin Research and Genetic Epidemiology

Alena Stančáková

University of Eastern Finland

Jakob Stokholm

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

Konstantin Strauch

Helmholtz Zentrum München Research Center for Environmental Health

E-Shyong Tai

National University of Singapore (NUS) - Department of Medicine

Kent D. Taylor

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Betina H. Thuesen

Bispebjerg and Frederiksberg Hospitals

Anke Tönjes

University of Leipzig

Emmanouil Tsafantakis

Anogia Medical Centre

Tiinamaija Tuomi

Folkhälsan Research Center

Jaakko Tuomilehto

National Institute for Health and Welfare

Understanding Society Scientific Group

Matti I. Uusitupa

University of Eastern Finland

Marja Vääräsmäki

University of Oulu

Ilonca Vaartjes

University Medical Center (Utrecht)

Magdalena Zoledziewska

Cittadella Universitaria

Goncalo Abecasis

University of Michigan at Ann Arbor

Beverley Balkau

Centre de Recherche en Épidémiologie et Santé des Populations (CESP)

Hans Bisgaard

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

Alexandra I. Blakemore

Brunel University London

Matthias Blüher

University of Leipzig - Department of Medicine

Heiner Boeing

German Institute of Human Nutrition - Department of Epidemiology

Eric Boerwinkle

University of Texas at Houston

Klaus Bønnelykke

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

Erwin P. Bottinger

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

Mark J. Caulfield

Queen Mary University of London - William Harvey Research Institute

John C. Chambers

Imperial College London

Daniel I. Chasman

Brigham and Women's Hospital

Ching-Yu Cheng

Singapore National Eye Centre - Singapore Eye Research Institute

Anne Clark

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Francis S. Collins

National Institutes of Health (NIH)

Josef Coresh

Johns Hopkins University

Francesco Cucca

Italian National Research Council (CNR) - Istituto di Ricerca Genetica e Biomedica (IRGB)

Gert J. de Borst

University Medical Center (Utrecht)

Ian J. Deary

University of Edinburgh - School of Philosophy, Psychology and Language Studies

George Dedoussis

Harokopio University

Panos Deloukas

Queen Mary University of London - William Harvey Research Institute

Hester M. den Ruijter

University Medical Center (Utrecht)

Josée Dupuis

Boston University - Department of Biostatistics

Michele K. Evans

Government of the United States of America - Laboratory of Epidemiology and Population Sciences

Ele Ferrannini

University of Pisa

Oscar H. Franco

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Harald Grallert

German Center for Diabetes Research; Helmholtz Zentrum München - Institute of Epidemiology (EPI)

Leif Groop

Lund University - Department of Clinical Sciences

Torben Hansen

University of Copenhagen - Faculty of Health and Medical Sciences

Andrew T. Hattersley

University of Exeter - Medical School

Caroline Hayward

University of Edinburgh - MRC Human Genetics Unit

Joel N. Hirschhorn

Harvard University - Department of Pediatrics

M. Arfan Ikram

Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Erik Ingelsson

Stanford University - Division of Cardiology

Fredrik Karpe

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Kay-Tee Kaw

University of Cambridge - Department of Public Health and Primary Care

Wieland Kiess

University of Leipzig - Center for Pediatric Research

Jaspal S. Kooner

Imperial College London

Antje Körner

University of Leipzig

Timo Lakka

University of Eastern Finland - Institute of Biomedicine

Claudia Langenberg

University of Cambridge - MRC Epidemiology Unit; Government of the United Kingdom - Public Health England; Francis Crick Institute

Lars Lind

Uppsala University - Department of Medical Sciences

Cecilia M. Lindgren

Masssachusetts Institute of Technology and Harvard University - Broad Institute

Allan Linneberg

Bispebjerg and Frederiksberg Hospitals

Leonard Lipovich

Wayne State University

Ching-Ti Liu

Boston University - Department of Biostatistics

Jun Liu

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Yongmei Liu

Wake Forest University

Ruth J. F. Loos

Mount Sinai Health System - Charles Bronfman Institute for Personalized Medicine

Patrick E. MacDonald

University of Alberta

Karen L. Mohlke

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

Andrew D. Morris

University of Edinburgh - Usher Institute of Population Health Sciences and Informatics

Patricia B. Munroe

Queen Mary University of London - William Harvey Research Institute

Alison Murray

University of Aberdeen

Sandosh Padmanabhan

University of Glasgow

Colin N. A. Palmer

University of Dundee - Division of Population Health and Genomics

Gerard Pasterkamp

University Medical Center (Utrecht)

Oluf Pedersen

University of Copenhagen - Faculty of Health and Medical Sciences

Patricia A. Peyser

University of Michigan at Ann Arbor - Department of Epidemiology

Ozren Polasek

University of Split

David Porteous

University of Edinburgh

Michael A. Province

Washington University in St. Louis

Bruce M. Psaty

University of Washington

Rainer Rauramaa

Kuopio Research Institute of Exercise Medicine

Paul M. Ridker

Brigham and Women's Hospital

Olov Rolandsson

University of Umea

Patrik Rorsman

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Frits Rosendaal

Leiden University - Medical Center (LUMC)

Igor Rudan

University of Edinburgh - Usher Institute of Population Health Sciences and Informatics

Veikko Salomaa

National Institute for Health and Welfare

Matthias B. Schulze

German Institute of Human Nutrition

Robert Sladek

McGill University - Department of Medicine

Blair H. Smith

University of Dundee - Division of Population Health and Genomics

Timothy D. Spector

King's College London, Department of Twin Research and Genetic Epidemiology

John M. Starr

University of Edinburgh

Michael Stumvoll

University of Leipzig

Cornelia M. van Duijn

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Mark Walker

University of Newcastle - Institute of Cellular Medicine

Nick J. Wareham

University of Cambridge - MRC Epidemiology Unit

David R. Weir

University of Michigan at Ann Arbor

James G. Wilson

University of Mississippi - Medical Center

Tien Yin Wong

Singapore National Eye Centre - Singapore Eye Research Institute

Eleftheria Zeggini

Wellcome Trust Sanger Institute

Alan B. Zonderman

Government of the United States of America - Laboratory of Epidemiology and Population Sciences

Jerome I. Rotter

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Andrew P. Morris

University of Liverpool - Department of Biostatistics

Michael Boehnke

University of Michigan at Ann Arbor

Jose Florez

Massachusetts General Hospital

Mark I. McCarthy

University of Oxford - Wellcome Centre for Human Genetics; University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

James B. Meigs

Massachusetts General Hospital

Anubha Mahajan

University of Oxford - Wellcome Trust Centre for Human Genetics

Robert A. Scott

University of Cambridge - MRC Epidemiology Unit

Anna L. Gloyn

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Ines Barroso

Wellcome Trust Sanger Institute

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Abstract

Metabolic dysregulation in multiple tissues influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits we investigated associations of exome-array variants in up to 144,060 nondiabetic individuals of multiple ancestries. Single-variant analyses identified 21 novel coding variant associations (18 loci), whilst gene-based tests revealed novel signals at TF (HbA1c) and G6PC [(Fasting Glucose (FG), Fasting Insulin (FI)]. Pathway and tissue enrichment analyses of trait-associated transcripts confirmed the importance of  liver and kidney for FI and islets for FG, implicated adipose tissue in FI and gut in 2hGlu, and a role for the non-endocrine pancreas in glucose homeostasis. Functional studies demonstrated that the liver-enriched G6PC and the islet-specific G6PC2 were driven by multiple rare variants, with G6PC2 including two alleles within the same codon with divergent effects on glucose levels. Our findings highlight the value of integrating genomic and functional data to maximize biological inference.

Keywords: genetics, Genomics, glycemic traits, type 2 diabetes, tissue, pathways, effector transcript

Suggested Citation

Ng, Natasha and Willems, Sara M. and Fernandez, Juan and Fine, Rebecca S. and Wheeler, Eleanor and Wessel, Jennifer and Kitajima, Hidetoshi and Marenne, Gaëlle and Rundle, Jana K. and Sim, Xueling and Yeghootkar, Hanieh and Beer, Nicola L. and Raimondo, Anne and Tarasov, Andrei I. and Thomsen, Soren K. and van de Bunt, Martijn and Wang, Shuai and Chen, Sai and Chen, Yuning and Chen, Yii-Der Ida and de Haan, Hugoline G. and Grarup, Niels and Li-Gao, Ruifang and Varga, Tibor V. and Asimit, Jennifer L and Feng, Shuang and Strawbridge, Rona J. and Kleinbrink, Erica L. and Ahluwalia, Tarunveer S. and An, Ping and Appel, Emil V. and Arking, Dan E and Auvinen, Juha and Bielak, Lawrence F. and Bihlmeyer, Nathan A. and Bork-Jensen, Jette and Brody, Jennifer A. and Campbell, Archie and Chu, Audrey Y and Davies, Gail and Demirkan, Ayse and Floyd, James S. and Giulianini, Franco and Guo, Xiuqing and Gustafsson, Stefan and Hastoy, Benoit and Jackson, Anne U. and Jakobsdottir, Johanna and Järvelin, Marjo-Riitta and Jensen, Richard A. and Kanoni, Stavroula and Keinanen-Kiukaanniemi, Sirkka and Li, Jin and Li, Man and Lohman, Kurt and Lu, Yingchang and Luan, Jian’an and Manning, Alisa K. and Marten, Jonathan and Marzi, Carola and Meidtner, Karina and Mook-Kanamori, Dennis O. and Muka, Taulant and Pistis, Giorgio and Prins, Bram and Rice, Kenneth M. and Robertson, Neil and Sanna, Serena and Shi, Yuan and Smith, Albert Vernon and Smith, Jennifer A. and Southam, Lorraine and Stringham, Heather M. and Tajuddin, Salman M. and Tragante, Vinicius and van der Laan, Sander W. and Warren, Helen R. and Yao, Jie and Yiorkas, Andrianos M. and Zhang, Weihua and Zhao, Wei and Ahlqvist, Emma and Graff, Mariaelisa and Highland, Heather M. and Justice, Anne E. and Lo, Ken Sin and Marouli, Eirini and Medina-Gomez, Carolina and Afaq, Saima and Alhejily, Wesam A. and Amin, Najaf and Asselbergs, Folkert W. and Bonnycastle, Lori L. and Bots, Michiel L. and Brandslund, Ivan and Chen, Ji and Christensen, Cramer and Danesh, John and de Mutsert, Renée and Dehghan, Abbas and Ebeling, Tapani and Elliott, Paul and Consortium, EPIC-InterAct and Farmaki, Aliki-Eleni and Faul, Jessica D. and Franks, Paul W. and Franks, Steve and Fritsche, Andreas and Gjesing, Anette P. and Goodarzi, Mark O. and Gudnason, Vilmundur and Hallmans, Göran and Harris, Tamara B. and Herzig, Karl-Heinz and Hivert, Marie-France and Jansson, Jan-Håkan and Jhun, Min A. and Beck Jørgensen, Torben and Jørgensen, Marit E. and Jousilahti, Pekka and Kajantie, Eero and Karaleftheri, Maria and Kardia, Sharon L.R. and Kinnunen, Leena and Koistinena, Heikki A. and Komulainen, Pirjo and Kovacs, Peter and Kuusisto, Johanna and Laakso, Markku and Lange, Leslie A. and Launer, Lenore J. and Lee, Jung-Jin and Leong, Aaron and Lindström, Jaana and Fox, Jocelyn E. Manning and Männistö, Satu and Maruthur, Nisa M. and Moilanen, Leena and Mulas, Antonella and Nalls, Mike A. and Neville, Matthew and Pankow, James S. and Pattie, Alison and Petersen, Eva R. B. and Puolijoki, Hannu and Rasheed, Asif and Redmond, Paul and Renström, Frida and Roden, Michael and Saleheen, Danish and Saltevo, Juha and Savonen, Kai and Sébert, Sylvain P. and Skaaby, Tea and Small, Kerrin S. and Stančáková, Alena and Stokholm, Jakob and Strauch, Konstantin and Tai, E-Shyong and Taylor, Kent D. and Thuesen, Betina H. and Tönjes, Anke and Tsafantakis, Emmanouil and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Group, Understanding Society Scientific and Uusitupa, Matti I. and Vääräsmäki, Marja and Vaartjes, Ilonca and Zoledziewska, Magdalena and Abecasis, Goncalo and Balkau, Beverley and Bisgaard, Hans and Blakemore, Alexandra I. and Blüher, Matthias and Boeing, Heiner and Boerwinkle, Eric and Bønnelykke, Klaus and Bottinger, Erwin P. and Caulfield, Mark J. and Chambers, John C. and Chasman, Daniel I. and Cheng, Ching-Yu and Clark, Anne and Collins, Francis S. and Coresh, Josef and Cucca, Francesco and de Borst, Gert J. and Deary, Ian J. and Dedoussis, George and Deloukas, Panos and den Ruijter, Hester M. and Dupuis, Josée and Evans, Michele K. and Ferrannini, Ele and Franco, Oscar H. and Grallert, Harald and Groop, Leif and Hansen, Torben and Hattersley, Andrew T. and Hayward, Caroline and Hirschhorn, Joel N. and Ikram, M. Arfan and Ingelsson, Erik and Karpe, Fredrik and Kaw, Kay-Tee and Kiess, Wieland and Kooner, Jaspal S. and Körner, Antje and Lakka, Timo and Langenberg, Claudia and Lind, Lars and Lindgren, Cecilia M. and Linneberg, Allan and Lipovich, Leonard and Liu, Ching-Ti and Liu, Jun and Liu, Yongmei and Loos, Ruth J. F. and MacDonald, Patrick E. and Mohlke, Karen L. and Morris, Andrew D. and Munroe, Patricia B. and Murray, Alison and Padmanabhan, Sandosh and Palmer, Colin N. A. and Pasterkamp, Gerard and Pedersen, Oluf and Peyser, Patricia A. and Polasek, Ozren and Porteous, David and Province, Michael A. and Psaty, Bruce M. and Rauramaa, Rainer and Ridker, Paul M. and Rolandsson, Olov and Rorsman, Patrik and Rosendaal, Frits and Rudan, Igor and Salomaa, Veikko and Schulze, Matthias B. and Sladek, Robert and Smith, Blair H. and Spector, Timothy D. and Starr, John M. and Stumvoll, Michael and van Duijn, Cornelia M. and Walker, Mark and Wareham, Nick J. and Weir, David R. and Wilson, James G. and Wong, Tien Yin and Zeggini, Eleftheria and Zonderman, Alan B. and Rotter, Jerome I. and Morris, Andrew P. and Boehnke, Michael and Florez, Jose and McCarthy, Mark I. and Meigs, James B. and Mahajan, Anubha and Scott, Robert A. and Gloyn, Anna L. and Barroso, Ines, Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation (October 15, 2019). Available at SSRN: https://ssrn.com/abstract=3469835 or http://dx.doi.org/10.2139/ssrn.3469835
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Natasha Ng (Contact Author)

University of Oxford

Sara M. Willems

University of Cambridge

Juan Fernandez

University of Oxford - Wellcome Centre for Human Genetics

Oxford, OX3 7BN
United Kingdom

Rebecca S. Fine

Harvard University - Department of Genetics

Boston, MA 02115
United States

Eleanor Wheeler

Wellcome Trust Sanger Institute

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

Jennifer Wessel

Indiana University - Department of Epidemiology and Biostatistics

Bloomington, ID
United States

Hidetoshi Kitajima

University of Oxford - Wellcome Centre for Human Genetics

Oxford, OX3 7BN
United Kingdom

Gaëlle Marenne

Wellcome Trust Sanger Institute

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

Jana K. Rundle

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

Xueling Sim

National University of Singapore (NUS) - Saw Swee Hock School of Public Health

12 Science Drive 2
#10-01
117549
Singapore

Hanieh Yeghootkar

University of Exeter - Medical School

Exeter
United Kingdom

Nicola L. Beer

University of Oxford

Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom

Anne Raimondo

University of Oxford

Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom

Andrei I. Tarasov

University of Oxford

Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom

Soren K. Thomsen

University of Oxford

Mansfield Road
Oxford, Oxfordshire OX1 4AU
United Kingdom

Martijn Van de Bunt

University of Oxford - Wellcome Centre for Human Genetics

Oxford, OX3 7BN
United Kingdom

Shuai Wang

Boston University - Department of Biostatistics

Boston, MA
United States

Sai Chen

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Yuning Chen

Boston University - Department of Biostatistics

Boston, MA
United States

Yii-Der Ida Chen

UCLA Medical Center

Los Angeles, CA
United States

Hugoline G. De Haan

Leiden University - Medical Center (LUMC)

Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands

Niels Grarup

University of Copenhagen - Novo Nordisk Foundation Center for Protein Research

Nørregade 10
Copenhagen, København DK-1165
Denmark

Ruifang Li-Gao

Leiden University - Medical Center (LUMC)

Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands

Tibor V. Varga

Lund University

Box 117
Lund, SC Skane S221 00
Sweden

Jennifer L Asimit

Wellcome Genome Campus - Wellcome Trust Sanger Institute

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

Wellcome Genome Campus - Wellcome Trust Sanger Institute

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

Shuang Feng

University of Michigan at Ann Arbor - School of Public Health

1415 Washington Heights
Ann Arbor, MI 48109-2029
United States

Rona J. Strawbridge

University of Glasgow - College of Medical, Veterinary & Life Sciences

Wolfson Medical School Building
University Avenue
Glasgow, Scotland G12 8QQ
United Kingdom

Erica L. Kleinbrink

Wayne State University

Detroit, MI 48202
United States

Tarunveer S. Ahluwalia

University of Copenhagen - Herlev Hospital

Herlev Ringvej 75
DK-2730 Herlev
Denmark

Ping An

Washington University in St. Louis - Department of Genetics

4515 McKinley Ave
St. Louis, WA 63110
United States

Emil V. Appel

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Dan E Arking

Johns Hopkins University - School of Medicine

733 North Broadway
Suite G-49
Baltimore, MD 21205-2196
United States

Juha Auvinen

University of Oulu

P.O. Box 4600
Oulu FIN-90014, 90570
Finland

Lawrence F. Bielak

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Nathan A. Bihlmeyer

Johns Hopkins University - School of Medicine

733 North Broadway
Suite G-49
Baltimore, MD 21205-2196
United States

Jette Bork-Jensen

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Jennifer A. Brody

University of Washington

Seattle, WA 98195
United States

Archie Campbell

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Audrey Y Chu

Harvard University - Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Gail Davies

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Ayse Demirkan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

James S. Floyd

University of Washington

Seattle, WA 98195
United States

Franco Giulianini

Harvard University - Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Xiuqing Guo

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Stefan Gustafsson

Uppsala University

Box 513
Uppsala, 751 20
Sweden

Benoit Hastoy

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

Anne U. Jackson

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Johanna Jakobsdottir

Icelandic Heart Association

Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland

Marjo-Riitta Järvelin

University of Oulu

P.O. Box 4600
Oulu FIN-90014, 90570
Finland

Richard A. Jensen

University of Washington

Seattle, WA 98195
United States

Stavroula Kanoni

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Sirkka Keinanen-Kiukaanniemi

University of Oulu - Centre for Life Course Health Research

Finland

Jin Li

Stanford University - Division of Cardiovascular Medicine

Stanford, CA
United States

Man Li

University of Utah

1645 E. Campus Center
Salt Lake City, UT 84112
United States

Kurt Lohman

Wake Forest University

2601 Wake Forest Road
Winston-Salem, NC 27109
United States

Yingchang Lu

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Jian’an Luan

University of Cambridge - MRC Epidemiology Unit

United Kingdom

Alisa K. Manning

Harvard University - Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Jonathan Marten

University of Edinburgh - Medical Research Council Human Genetics Unit

Edinburgh
United Kingdom

Carola Marzi

Helmholtz Association of German Research Centres - Helmholtz Zentrum München

Ingolstaedter Landstraße 1
Neuherberg, Bavaria D-85764
Germany

Karina Meidtner

German Institute of Human Nutrition

Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany

Dennis O. Mook-Kanamori

Leiden University

Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands

Taulant Muka

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Doctor Molewaterplein 40
Rotterdam, South Holland 3015 GD
Netherlands

Giorgio Pistis

Cittadella Universitaria

Monserrato, 09042
Italy

Bram Prins

Wellcome Sanger Institute - Department of Human Genetics

Hinxton, Cambridge
United Kingdom

Kenneth M. Rice

University of Washington

Seattle, WA 98195
United States

Neil Robertson

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Serena Sanna

Cittadella Universitaria

Monserrato, 09042
Italy

Yuan Shi

Singapore National Eye Centre - Singapore Eye Research Institute

168751
Singapore

Albert Vernon Smith

Icelandic Heart Association

Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland

Jennifer A. Smith

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Lorraine Southam

Wellcome Sanger Institute - Department of Human Genetics

Hinxton, Cambridge
United Kingdom

Heather M. Stringham

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Salman M. Tajuddin

National Institutes of Health - Laboratory of Epidemiology and Population Sciences

United States

Vinicius Tragante

Utrecht University

Vredenburg 138
Utrecht, 3511 BG
Netherlands

Sander W. Van der Laan

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Helen R. Warren

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Jie Yao

UCLA Medical Center

Santa Monica, CA
United States

Andrianos M. Yiorkas

Imperial College London

South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom

Weihua Zhang

Imperial College London - Department of Epidemiology and Biostatistics

London
United Kingdom

Wei Zhao

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Emma Ahlqvist

Lund University - Diabetes Centre

Malmö
Sweden

Mariaelisa Graff

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Heather M. Highland

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Anne E. Justice

University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology

Chapel Hill, NC 27599
United States

Ken Sin Lo

University of Montreal - Université de Montreal

H3T 1J4
2350 Édouard Montpetit 11139
Montréal, Quebec H3T 1J4
Canada

Eirini Marouli

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Carolina Medina-Gomez

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Saima Afaq

Imperial College London - Department of Epidemiology and Biostatistics

London
United Kingdom

Wesam A. Alhejily

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Najaf Amin

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Folkert W. Asselbergs

Utrecht University - University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Netherlands Heart Institute

Netherlands

University College London

Gower Street
London, WC1E 6BT
United Kingdom

Lori L. Bonnycastle

Government of the United States of America - National Institutes of Health (NIH)

9000 Rockville Pike
Bethesda, MD 20892
United States

Michiel L. Bots

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Ivan Brandslund

Lillebaelt Hospital

Vejle
Denmark

Ji Chen

Wellcome Sanger Institute - Department of Human Genetics

Hinxton, Cambridge
United Kingdom

Cramer Christensen

Lillebaelt Hospital

Vejle
Denmark

John Danesh

University of Cambridge - Department of Public Health and Primary Care

Cambridge
United Kingdom

Renée De Mutsert

Leiden University

Postbus 9500
Leiden, Zuid Holland 2300 RA
Netherlands

Abbas Dehghan

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Tapani Ebeling

Oulu University Hospital

Oulu
United States

Paul Elliott

Imperial College London - Department of Epidemiology and Biostatistics ( email )

St Mary's Campus
Norfolk Pl, Paddington
London, W2 1QN
United Kingdom

Aliki-Eleni Farmaki

Harokopio University

Greece

Jessica D. Faul

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Paul W. Franks

Lund University - Department of Clinical Sciences

Sweden

Steve Franks

Imperial College London - Institute of Reproductive and Developmental Biology

London
United Kingdom

Andreas Fritsche

University of Tuebingen - University Hospitals Tübingen

Geschwister-Scholl-Platz
Tübingen, 72074
Germany

Anette P. Gjesing

University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Mark O. Goodarzi

Cedars Sinai Medical Center

8700 Beverly Blvd.
Los Angeles, CA 90048
United States

Vilmundur Gudnason

Icelandic Heart Association

Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland

Göran Hallmans

University of Umea

Samhallsvetarhuset, Plan 2
Umea University
Umeå, SE 901 87
Sweden

Tamara B. Harris

Icelandic Heart Association

Hjartavernd / Holtasmára 1
201 Kópavogur
Iceland

Karl-Heinz Herzig

University of Oulu - Department of Physiology ( email )

Oulu
Finland

Marie-France Hivert

Harvard Medical School

1875 Cambridge Street
Cambridge, MA 02138
United States

Jan-Håkan Jansson

University of Umea - Department of Public Health and Clinical Medicine

SE-901 87
Umeå
Sweden

Min A. Jhun

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Torben Beck Jørgensen

University of Copenhagen ( email )

Nørregade 10
Copenhagen, København DK-1165
Denmark

Marit E. Jørgensen

Steno Diabetes Center Copenhagen

Denmark

Pekka Jousilahti

National Institute for Health and Welfare

Helsinki
Finland

Eero Kajantie

University of Oulu

P.O. Box 4600
Oulu FIN-90014, 90570
Finland

Maria Karaleftheri

Echinos Medical Centre

Echinos
Greece

Sharon L.R. Kardia

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Leena Kinnunen

National Institute for Health and Welfare

Helsinki
Finland

Heikki A. Koistinena

National Institute for Health and Welfare

Helsinki
Finland

Pirjo Komulainen

Kuopio Research Institute of Exercise Medicine

Kuopio, 70100
Finland

Peter Kovacs

University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases

Germany

Johanna Kuusisto

University of Eastern Finland

PO Box 111
Joensuu, 80100
Finland

Markku Laakso

University of Eastern Finland ( email )

PO Box 111
Joensuu, 80100
Finland

Leslie A. Lange

University of Colorado at Denver

Box 173364
1250 14th Street
Denver, CO 80217
United States

Lenore J. Launer

National Institute for Health and Welfare

Helsinki
Finland

Jung-Jin Lee

University of Pennsylvania

Philadelphia, PA 19104
United States

Aaron Leong

Harvard Medical School

25 Shattuck St
Boston, MA 02115
United States

Jaana Lindström

National Institute for Health and Welfare

Helsinki
Finland

Jocelyn E. Manning Fox

University of Alberta

Edmonton, Alberta T6G 2R3
Canada

Satu Männistö

National Institute for Health and Welfare

Helsinki
Finland

Nisa M. Maruthur

Johns Hopkins University

Baltimore, MD 20036-1984
United States

Leena Moilanen

Kuopio University Hospital

Kuopio, 70210
Finland

Antonella Mulas

Cittadella Universitaria

Monserrato, 09042
Italy

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Bethseda, MD 20892
United States

Matthew Neville

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

James S. Pankow

University of Minnesota - Minneapolis - Division of Epidemiology and Community Health

1300 S. 2nd St.
300 West Bank Office Building
Minneapolis, MN 55454
United States

Alison Pattie

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Eva R. B. Petersen

Odense University Hospital

J. B. Winsløws Vej 4
Odense
Denmark

Hannu Puolijoki

South Ostobothnia Central Hospital

Seinajoki, 60220
Finland

Asif Rasheed

Center for Non-Communicable Diseases

Karachi
Pakistan

Paul Redmond

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Frida Renström

Lund University - Department of Clinical Sciences

Sweden

Michael Roden

Heinrich Heine University Dusseldorf

Universitätsstrasse 1
Duesseldorf, DE NRW 40225
Germany

Danish Saleheen

University of Pennsylvania

Philadelphia, PA 19104
United States

Juha Saltevo

Central Finland Central Hospital

Jyvaskyla, 40620
Finland

Kai Savonen

Kuopio Research Institute of Exercise Medicine

Kuopio, 70100
Finland

Sylvain P. Sébert

University of Oulu - Centre for Life Course Health Research ( email )

Finland
+358 503440842 (Phone)

Tea Skaaby

Bispebjerg and Frederiksberg Hospitals

Bispebjerg Bakke 23
2400 København
Denmark

Kerrin S. Small

University of London - Department of Twin Research and Genetic Epidemiology

London
United Kingdom

Alena Stančáková

University of Eastern Finland

PO Box 111
Joensuu, 80100
Finland

Jakob Stokholm

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

Ledreborg Alle 34
Gentofte, 2820
Denmark

Konstantin Strauch

Helmholtz Zentrum München Research Center for Environmental Health

Ingolstaedter Landstraße 1
Neuherberg, Bavaria D-85764
Germany

E-Shyong Tai

National University of Singapore (NUS) - Department of Medicine

Singapore

Kent D. Taylor

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Betina H. Thuesen

Bispebjerg and Frederiksberg Hospitals

Bispebjerg Bakke 23
2400 København
Denmark

Anke Tönjes

University of Leipzig

Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany

Emmanouil Tsafantakis

Anogia Medical Centre

Anogia
Greece

Tiinamaija Tuomi

Folkhälsan Research Center

Finland

Jaakko Tuomilehto

National Institute for Health and Welfare

Helsinki
Finland

Matti I. Uusitupa

University of Eastern Finland ( email )

PO Box 111
Joensuu, 80100
Finland

Marja Vääräsmäki

University of Oulu

P.O. Box 4600
Oulu FIN-90014, 90570
Finland

Ilonca Vaartjes

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Magdalena Zoledziewska

Cittadella Universitaria

Monserrato, 09042
Italy

Goncalo Abecasis

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Beverley Balkau

Centre de Recherche en Épidémiologie et Santé des Populations (CESP)

France

Hans Bisgaard

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC) ( email )

Ledreborg Alle 34
Gentofte, 2820
Denmark

Alexandra I. Blakemore

Brunel University London

Kingston Lane
Uxbridge, Middlesex UB8 3PH
United Kingdom

Matthias Blüher

University of Leipzig - Department of Medicine

Germany

Heiner Boeing

German Institute of Human Nutrition - Department of Epidemiology ( email )

Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany

Eric Boerwinkle

University of Texas at Houston

Houston, TX 77030
United States

Klaus Bønnelykke

Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC)

Ledreborg Alle 34
Gentofte, 2820
Denmark

Erwin P. Bottinger

Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Mark J. Caulfield

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

John C. Chambers

Imperial College London

South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom

Daniel I. Chasman

Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Ching-Yu Cheng

Singapore National Eye Centre - Singapore Eye Research Institute ( email )

168751
Singapore

Anne Clark

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

Francis S. Collins

National Institutes of Health (NIH)

9000 Rockville Pike
Bethesda, MD 20892
United States

Josef Coresh

Johns Hopkins University

Baltimore, MD 20036-1984
United States

Francesco Cucca

Italian National Research Council (CNR) - Istituto di Ricerca Genetica e Biomedica (IRGB)

SS 554 bivio per Sestu Km 4,500
Monserrato, 09042
Italy

Gert J. De Borst

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Ian J. Deary

University of Edinburgh - School of Philosophy, Psychology and Language Studies ( email )

Teviot Place
Edinbrurgh, EH8 9AG
United Kingdom

George Dedoussis

Harokopio University

Greece

Panos Deloukas

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Hester M. Den Ruijter

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Josée Dupuis

Boston University - Department of Biostatistics

Boston, MA
United States

Michele K. Evans

Government of the United States of America - Laboratory of Epidemiology and Population Sciences

United States

Ele Ferrannini

University of Pisa

Lungarno Pacinotti, 43
Pisa PI, 56126
Italy

Oscar H. Franco

Erasmus University Rotterdam (EUR) - Department of Epidemiology ( email )

Rotterdam
Netherlands

Harald Grallert

German Center for Diabetes Research

85764 Neuherberg
Germany

Helmholtz Zentrum München - Institute of Epidemiology (EPI)

Neuherberg, Bavaria
Germany

Leif Groop

Lund University - Department of Clinical Sciences

Sweden

Torben Hansen

University of Copenhagen - Faculty of Health and Medical Sciences

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Andrew T. Hattersley

University of Exeter - Medical School

Exeter
United Kingdom

Caroline Hayward

University of Edinburgh - MRC Human Genetics Unit

Edinburgh
United Kingdom

Joel N. Hirschhorn

Harvard University - Department of Pediatrics

Boston, MA
United States

M. Arfan Ikram

Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology

Rotterdam
Netherlands

Erik Ingelsson

Stanford University - Division of Cardiology

Stanford, CA
United States

Fredrik Karpe

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

Kay-Tee Kaw

University of Cambridge - Department of Public Health and Primary Care

Cambridge
United Kingdom

Wieland Kiess

University of Leipzig - Center for Pediatric Research

Leipzig
Germany

Jaspal S. Kooner

Imperial College London

South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom

Antje Körner

University of Leipzig

Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany

Timo Lakka

University of Eastern Finland - Institute of Biomedicine

PO Box 111
Joensuu, 80100
Finland

Claudia Langenberg

University of Cambridge - MRC Epidemiology Unit

United Kingdom

Government of the United Kingdom - Public Health England

Wellington House
133-155 Waterloo Road
London, SE1 8UG
United Kingdom

Francis Crick Institute

1 Midland Road
London, NW1 1AT
United Kingdom

Lars Lind

Uppsala University - Department of Medical Sciences

Uppsala
Sweden

Cecilia M. Lindgren

Masssachusetts Institute of Technology and Harvard University - Broad Institute

415 Main Street
Cambridge, MA 02142
United States

Allan Linneberg

Bispebjerg and Frederiksberg Hospitals

Bispebjerg Bakke 23
2400 København
Denmark

Leonard Lipovich

Wayne State University

Detroit, MI 48202
United States

Ching-Ti Liu

Boston University - Department of Biostatistics

Boston, MA
United States

Jun Liu

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Yongmei Liu

Wake Forest University

2601 Wake Forest Road
Winston-Salem, NC 27109
United States

Ruth J. F. Loos

Mount Sinai Health System - Charles Bronfman Institute for Personalized Medicine

1468 Madison Avenue
New York, NY 10029
United States

Patrick E. MacDonald

University of Alberta

Edmonton, Alberta T6G 2R3
Canada

Karen L. Mohlke

University of North Carolina (UNC) at Chapel Hill - Department of Genetics

102 Ridge Road
Chapel Hill, NC 27514
United States

Andrew D. Morris

University of Edinburgh - Usher Institute of Population Health Sciences and Informatics

Teviot Place
Edinburgh, EH8 9AG
United Kingdom

Patricia B. Munroe

Queen Mary University of London - William Harvey Research Institute

Charterhouse Square
London
United Kingdom

Alison Murray

University of Aberdeen

Dunbar Street
Aberdeen, Scotland AB24 3QY
United Kingdom

Sandosh Padmanabhan

University of Glasgow

Adam Smith Business School
Glasgow, Scotland G12 8LE
United Kingdom

Colin N. A. Palmer

University of Dundee - Division of Population Health and Genomics ( email )

Dundee
United Kingdom

Gerard Pasterkamp

University Medical Center (Utrecht)

6.119, PO Box 85500
Utrecht, 3508 GA
Netherlands

Oluf Pedersen

University of Copenhagen - Faculty of Health and Medical Sciences

Blegdamsvej 3B
Copenhagen, DK-2200
Denmark

Patricia A. Peyser

University of Michigan at Ann Arbor - Department of Epidemiology

Ann Arbor, MI
United States

Ozren Polasek

University of Split

Livanjska ulica 5
Split, 21000
Croatia

David Porteous

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Michael A. Province

Washington University in St. Louis

One Brookings Drive
Campus Box 1208
Saint Louis, MO MO 63130-4899
United States

Bruce M. Psaty

University of Washington

Seattle, WA 98195
United States

Rainer Rauramaa

Kuopio Research Institute of Exercise Medicine

Kuopio, 70100
Finland

Paul M. Ridker

Brigham and Women's Hospital

75 Francis St.
Boston, MA 02115
United States

Olov Rolandsson

University of Umea

Samhallsvetarhuset, Plan 2
Umea University
Umeå, SE 901 87
Sweden

Patrik Rorsman

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

Frits Rosendaal

Leiden University - Medical Center (LUMC)

Albinusdreef 2
Leiden, South Holland 2333 ZA
Netherlands

Igor Rudan

University of Edinburgh - Usher Institute of Population Health Sciences and Informatics

Teviot Place
Edinburgh, EH8 9AG
United Kingdom

Veikko Salomaa

National Institute for Health and Welfare

Helsinki
Finland

Matthias B. Schulze

German Institute of Human Nutrition

Arthur-Scheunert-Allee 114-116
Nuthetal, 14558
Germany

Robert Sladek

McGill University - Department of Medicine

Montreal, Quebec
Canada

Blair H. Smith

University of Dundee - Division of Population Health and Genomics

Dundee
United Kingdom

Timothy D. Spector

King's College London, Department of Twin Research and Genetic Epidemiology

London
United Kingdom

John M. Starr

University of Edinburgh

Old College
South Bridge
Edinburgh, Scotland EH8 9JY
United Kingdom

Michael Stumvoll

University of Leipzig

Marschnerstrasse 31
D-04109 Leipzig, 04109
Germany

Cornelia M. Van Duijn

Erasmus University Rotterdam (EUR) - Department of Epidemiology

Rotterdam
Netherlands

Mark Walker

University of Newcastle - Institute of Cellular Medicine

Framlington Place
United Kingdom

Nick J. Wareham

University of Cambridge - MRC Epidemiology Unit

United Kingdom

David R. Weir

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

James G. Wilson

University of Mississippi - Medical Center

Jackson, MS 39216-4505
United States

Tien Yin Wong

Singapore National Eye Centre - Singapore Eye Research Institute ( email )

168751
Singapore

Eleftheria Zeggini

Wellcome Trust Sanger Institute

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

Alan B. Zonderman

Government of the United States of America - Laboratory of Epidemiology and Population Sciences

United States

Jerome I. Rotter

UCLA Medical Center - The Institute for Translational Genomics and Population Sciences

Santa Monica, CA
United States

Andrew P. Morris

University of Liverpool - Department of Biostatistics

United Kingdom

Michael Boehnke

University of Michigan at Ann Arbor

500 S. State Street
Ann Arbor, MI 48109
United States

Jose Florez

Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Mark I. McCarthy

University of Oxford - Wellcome Centre for Human Genetics

Oxford, OX3 7BN
United Kingdom

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism

Oxford, OX3 7LE
United Kingdom

James B. Meigs

Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Anubha Mahajan

University of Oxford - Wellcome Trust Centre for Human Genetics

Old Road Campus
Roosevelt Drive
Oxford, OX3 7FZ
United Kingdom

Robert A. Scott

University of Cambridge - MRC Epidemiology Unit

United Kingdom

Anna L. Gloyn

University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism ( email )

Oxford, OX3 7LE
United Kingdom

Ines Barroso

Wellcome Trust Sanger Institute ( email )

Hinxton, Saffron Walden
Cambridge, England CB10 1SA
United Kingdom

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No contact information is available for Understanding Society Scientific Group

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