Silibinin Releasing Mesoporous Bioactive Glass Nanoparticles: New Weapons Against Human Breast Cancer Cells

27 Pages Posted: 25 Oct 2019

See all articles by Qaisar Nawaz

Qaisar Nawaz

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Miguel Angel Fuentes

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Varun Tharmalingam

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Muhammad Atiq Ur Rehman

Institute of Space Technology - Department of Materials Science and Engineering

Aldo Leal-Egaña

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Aldo R. Boccaccini

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Abstract

Mesoporous materials have attracted extensive consideration in the field of drug delivery. The targeted release of anti-neoplastic agents depends on the carrier used to transport such drugs in the body. In this study, mesoporous bioactive glass nanoparticles (MBGN) were used to release silibinin, which is a natural flavonolignan, described as anticancer agent and tumor suppressor. Mesoporous bioactive glass nanoparticles were characterized in terms of morphology and release potential after being loaded with silibinin. The chemotherapeutic effect of this molecule was tested on metastatic MDA-MB-231 breast cells and the non-malignant breast cell line MCF-10. We found that mesoporous bioactive glass nanoparticles have maximum loading efficiency of 61 % against optimal silibinin concentration (i.e. 40 μg/ml silibinin solutions). This drug was released in a sustained manner from loaded mesoporous bioactive glass nanoparticles and a release of 18 μg/ml silibinin was recorded in the first 24 hours. The chemotherapeutic effect of silibinin was tested at two different concentrations (9.0 μg/ml and 18 μg /ml). Moreover, silibinin showed a chemotherapeutic potential towards MDA-MB-231 cells line, which is a much lower concentration compared to values reported in literature. According to our knowledge, this is the first study elucidating the use of MBGN as a carrier for silibinin, as well as testing its lethal effect in contact with breast neoplastic cells. Taken collectively, the present study suggests that the silibinin-loaded MBGN can be applied as an effective drug delivery system to cause chemo preventive response which will be beneficial for the treatment of breast cancer.

Keywords: Mesoporous nanoparticles, Silibinin, Breast cancer, Chemotherapeutic-agent, Drug delivery system, Bioactive glass

Suggested Citation

Nawaz, Qaisar and Fuentes, Miguel Angel and Tharmalingam, Varun and Atiq Ur Rehman, Muhammad and Leal-Egaña, Aldo and Boccaccini, Aldo R., Silibinin Releasing Mesoporous Bioactive Glass Nanoparticles: New Weapons Against Human Breast Cancer Cells. Available at SSRN: https://ssrn.com/abstract=3473993 or http://dx.doi.org/10.2139/ssrn.3473993

Qaisar Nawaz (Contact Author)

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Germany

Miguel Angel Fuentes

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Germany

Varun Tharmalingam

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials

Germany

Muhammad Atiq Ur Rehman

Institute of Space Technology - Department of Materials Science and Engineering

Pakistan

Aldo Leal-Egaña

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials ( email )

Germany

Aldo R. Boccaccini

Friedrich-Alexander-Universität Erlangen-Nürnberg - Institute of Biomaterials ( email )

Germany

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