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Fundamentals on the Molecular Mechanism of Action of Antimicrobial Peptides

34 Pages Posted: 29 Oct 2019 First Look: Accepted

See all articles by Jessica Audrey Feijó Corrêa

Jessica Audrey Feijó Corrêa

Pontifical Catholic University of Parana - School of Life Sciences

Alberto G. Evangelista

Pontifical Catholic University of Parana - School of Life Sciences

Tiago M. Nazareth

Pontifical Catholic University of Parana - School of Life Sciences; University of Valencia - Laboratory of Food Chemistry and Toxicology

Fernando B. Luciano

Pontifical Catholic University of Parana - School of Life Sciences

Abstract

Antimicrobial peptides (AMPs) are produced by several organisms as their first line of defense. Constituted by amino acids, they may present different mechanisms of action. The antimicrobial activity can be used by the peptide-producing organism itself, as innate immune strategy, or in the industry, applying as natural source preservatives. Understanding the possibilities of the operation of these compounds is a prerequisite for the development of effective uses, as well as for the establishment of combinations, which can even expand their applications considering the possibilities of genetic manipulations. Thus, the objective of this article is to review the basic principles of AMPs acting. The main mechanisms of peptides are related to changes in the physiological function of membranes, but there are also alterations in cytoplasmic components. We gathered the three most described and accepted, the barrel-stave, the carpet and the wormhole mechanisms, along with the possible microorganisms' mechanisms of resistance towards AMPs action. Such information may contribute to the process of choosing the best peptide to obtain an expected action against a given microorganism, optimizing the handling of financial and human resources in research projects.

Keywords: Antimicrobials resistance, Bioactive molecules, Peptides biochemistry

Suggested Citation

Corrêa, Jessica Audrey Feijó and Evangelista, Alberto G. and Nazareth, Tiago M. and Luciano, Fernando B., Fundamentals on the Molecular Mechanism of Action of Antimicrobial Peptides (2019). Available at SSRN: https://ssrn.com/abstract=3474484 or http://dx.doi.org/10.2139/ssrn.3474484

Jessica Audrey Feijó Corrêa (Contact Author)

Pontifical Catholic University of Parana - School of Life Sciences ( email )

Brazil

Alberto G. Evangelista

Pontifical Catholic University of Parana - School of Life Sciences

Brazil

Tiago M. Nazareth

Pontifical Catholic University of Parana - School of Life Sciences

Brazil

University of Valencia - Laboratory of Food Chemistry and Toxicology

Spain

Fernando B. Luciano

Pontifical Catholic University of Parana - School of Life Sciences

Brazil

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