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Long-Term Extreme Fasting Following a Traditional Chinese 'Bigu' Regimen: A Preliminary Retrospective and Prospective Cohort Study

37 Pages Posted: 13 Nov 2019

See all articles by Chao Wang

Chao Wang

Tsinghua University - School of Medicine

Ligang Ming

Nanshan Branch of Qilu Hospital

Lijun Jia

Shanghai Jiao Tong University (SJTU) - Department of Oncology; Shanghai University of Traditional Chinese Medicine - Cancer Institute

Qi Wang

Chinese Academy of Sciences (CAS)

Tingting Cao

Tsinghua University - School of Medicine

Liping Wang

Nanshan Branch of Qilu Hospital

Zijing Zhou

Tsinghua University - School of Medicine

Dan Tong

Tsinghua University - School of Medicine

Wei Li

Chinese Academy of Sciences (CAS) - Guangdong Institute of Microbiology

Yiqing Wu

Tsinghua University - School of Medicine

Hong Ding

Government of the People's Republic of China - 309th Hospital

Di Liu

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology

Minghui Zhang

Tsinghua University - School of Medicine

More...

Abstract

Background: Fasting has long been a ritual or practice in varied religions, and recently, has been noticed to reduce the risk factors of metabolic diseases. In China, varied populations performed a traditional Taoism fasting practice, called Bigu regimen, which lasted for 21-day with <5% calorie intake. However, the safety and applicability of this procedure haven not been investigated.

Methods: A total of 144 volunteered participants in six camps following the 21-day fasting (with <5% of normal diet) were investigated. 124 were examined for physical biomarkers and 53 of which also had biochemical markers. Another open label, non-comparative, phase 1/2 prospective cohort study enrolling 20 participants with metabolic diseases was also performed. The physical indices and biochemical biomarkers were collected at varied point of the fasting procedure. Statistical comparison and metagenomic analysis were performed.

Findings: Our preliminary retrospective cohort study showed that no severe adverse event (grade 3 or above) was reported, and all biomarkers fluctuated within the safe ranges, except for the urea acid. The 21-day fasting could significantly reduce BMI and blood pressures. The prospective cohort study of the metabolic diseased participants showed a significant reduction of BMI (3.3±1.0) and systolic blood pressure (28.7±17.8 mmHg) after the fasting procedure. The data also presented significant ameliorations on overweight (16/16), hypertension (11/11) and fatty liver (9/9).

Interpretation: The 21-day fasting appeared safe and feasible for both healthy and unhealthy people. It could ameliorate the risk factors associated with hypertension and hyperlipidemia.

Trial Registration: This study was registered in ClinicalTrials.gov (NCT03193177).

Funding Statement: The study was supported by National Natural Science Foundation of China (numbers 81571532, 81771687 and 81601429). MZ was supported by the China Overseas-Educated Scholars Development Foundation. DL was supported by the National Program for Support of Top-notch Young Professionals.

Declaration of Interests: The authors declare that they have no conflicts of interest.

Ethics Approval Statement: All participants have signed voluntary informed consent for collection and analysis of blood and fecal microbiome samples under Institutional Review Board (IRB)–approved protocols (THUMED-BG-170612). All clinical examination and evaluation was carried out independently and recorded instantaneously.

Keywords: Fasting, Bigu, metabolic disorder, hypertension, hyperlipidemia, fatty liver

Suggested Citation

Wang, Chao and Ming, Ligang and Jia, Lijun and Wang, Qi and Cao, Tingting and Wang, Liping and Zhou, Zijing and Tong, Dan and Li, Wei and Wu, Yiqing and Ding, Hong and Liu, Di and Zhang, Minghui, Long-Term Extreme Fasting Following a Traditional Chinese 'Bigu' Regimen: A Preliminary Retrospective and Prospective Cohort Study (10/23/2019 08:08:54). Available at SSRN: https://ssrn.com/abstract=3474499 or http://dx.doi.org/10.2139/ssrn.3474499

Chao Wang

Tsinghua University - School of Medicine

Beijing, 100084
China

Ligang Ming

Nanshan Branch of Qilu Hospital

Yantai
China

Lijun Jia

Shanghai Jiao Tong University (SJTU) - Department of Oncology

Shanghai
China

Shanghai University of Traditional Chinese Medicine - Cancer Institute ( email )

Shanghai, 200032
China

Qi Wang

Chinese Academy of Sciences (CAS)

52 Sanlihe Rd.
Datun Road, Anwai
Beijing, Xicheng District 100864
China

Tingting Cao

Tsinghua University - School of Medicine

Beijing, 100084
China

Liping Wang

Nanshan Branch of Qilu Hospital

Yantai
China

Zijing Zhou

Tsinghua University - School of Medicine

Beijing, 100084
China

Dan Tong

Tsinghua University - School of Medicine

Beijing, 100084
China

Wei Li

Chinese Academy of Sciences (CAS) - Guangdong Institute of Microbiology

Guangzhou, 510070
China

Yiqing Wu

Tsinghua University - School of Medicine

Beijing, 100084
China

Hong Ding

Government of the People's Republic of China - 309th Hospital ( email )

Beijing
China

Di Liu

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology ( email )

Jiangxia, Hubei
China

Minghui Zhang (Contact Author)

Tsinghua University - School of Medicine ( email )

Beijing, 100084
China

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