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Now published in The Lancet

Burden of Osteoarthritis in China, 1990 to 2017: Findings from the Global Burden of Disease Study 2017

30 Pages Posted: 17 Nov 2019

See all articles by Huibin Long

Huibin Long

Peking University - People’s Hospital

Xinying Zeng

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention

Qiang Liu

Peking University - People’s Hospital

Haidong Wang

University of Washington - The Institute for Health Metrics and Evaluation

Theo Vos

University of Washington - The Institute for Health Metrics and Evaluation

Yunfei Hou

Peking University - People’s Hospital

Chutong Lin

Peking University - People’s Hospital

Yudian Qiu

Peking University - People’s Hospital

Kai Wang

Peking University - People’s Hospital

Dan Xing

Peking University - People’s Hospital

Yuqing Zhang

Harvard University - Massachusetts General Hospital

Jianhao Lin

Peking University - People’s Hospital

Maigeng Zhou

Chinese Center for Disease Control and Prevention - Non-Communicable Disease Center

More...

Abstract

Background: China has experienced a remarkable epidemiological and demographic transition during the past three decades. We aimed to describe the prevalence and years lived with disability (YLDs) caused by osteoarthritis (OA) in China according to age, sex, and geographic location from 1990 to 2017.

Methods: Data came from systematic reviews of symptomatic OA at the knee and hip in the Global Burden of Diseases Injuries, and Risk Factors Study 2017 (GBD 2017). Three sequelae (mild, moderate and severe) of OA were developed to indicate levels of OA severity and its associated functional loss. A Bayesian meta-regression tool was applied to estimate prevalence of OA and its distribution of severity. YLDs were calculated by multiplying the prevalence of OA sequelae with the corresponding disability weight (DW). All data was analyzed by age-sex-province-year groups in China.

Findings: We estimated that 26·1 million individuals had OA in 1990, rising to 61·2 million in 2017. The age-standardized prevalence of OA increased from 2·9% (95% UI: 2·5%-3·3%) in 1990 to 3·1% (95% UI: 2·7%- 3·4%) in 2017. The YLDs of OA increased from 0.84 million (95% UI: 0·42- 1·69 million) in 1990 to 1·97 million (95% UI: 0·98-3·94 million) in 2017. The age-standardized YLDs rate (per 100,000 population) increased from 92·5 (95% UI: 45·7-185·6) in 1990 to 98·8 (95% UI: 49·4-197·6) in 2017. A female preponderance was observed for prevalence and YLDs due to OA.

Interpretation: OA prevalence is high in China. Between 1990 and 2017 disease burden increased and varied greatly according to geographic location. We call for the development of appropriate prevention and treatment strategies that predominantly target women, the elderly, and underdeveloped areas in order to reduce the burden of OA.

Funding Statement: National Natural Science Foundation of China.

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: Not required.

Keywords: Osteoarthritis; Epidemiology; Burden of OA across China

Suggested Citation

Long, Huibin and Zeng, Xinying and Liu, Qiang and Wang, Haidong and Vos, Theo and Hou, Yunfei and Lin, Chutong and Qiu, Yudian and Wang, Kai and Xing, Dan and Zhang, Yuqing and Lin, Jianhao and Zhou, Maigeng, Burden of Osteoarthritis in China, 1990 to 2017: Findings from the Global Burden of Disease Study 2017 (10/28/2019 13:59:21). Available at SSRN: https://ssrn.com/abstract=3478119 or http://dx.doi.org/10.2139/ssrn.3478119

Huibin Long

Peking University - People’s Hospital

China

Xinying Zeng

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Center for Chronic and Noncommunicable Disease Control and Prevention ( email )

Beijing 100050
China

Qiang Liu

Peking University - People’s Hospital

China

Haidong Wang

University of Washington - The Institute for Health Metrics and Evaluation

Seattle, WA
United States

Theo Vos

University of Washington - The Institute for Health Metrics and Evaluation

Seattle, WA
United States

Yunfei Hou

Peking University - People’s Hospital

China

Chutong Lin

Peking University - People’s Hospital

China

Yudian Qiu

Peking University - People’s Hospital

China

Kai Wang

Peking University - People’s Hospital

China

Dan Xing

Peking University - People’s Hospital

China

Yuqing Zhang

Harvard University - Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Jianhao Lin

Peking University - People’s Hospital ( email )

China

Maigeng Zhou (Contact Author)

Chinese Center for Disease Control and Prevention - Non-Communicable Disease Center ( email )

Beijing 100050
China

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