Characterization of Recrystallized Carbamazepine Using Acetone as Solvent

6 Pages Posted: 31 Oct 2019 Last revised: 6 Dec 2019

See all articles by Dewi Isadiartuti

Dewi Isadiartuti

Faculty of Pharmacy, Airlangga University

A. Radjaram

Faculty of Pharmacy, Airlangga University

P.D. Handini

Faculty of Pharmacy, Airlangga University

Date Written: September 30, 2019

Abstract

Carbamazepine is used as a first line drug in seizure treatment. It is classified as BCS class II according to the Biopharmaceutical classification system which means that carbamazepine has high membrane permeability and low water solubility. This makes dissolution the rate limiting process in carbamazepine absorption. Thus crystallization of carbamazepine using the solvent acetone was chosen to increase dissolution rates and improve the bioavailability of carbamazepine. This study therefore aims to compare the characteristics and dissolution rate of carbamazepine recrystallized with acetone using two methods; rapid cooling and solvent evaporation. Characterization of carbamazepine crystals was carried out using Differential Thermal Analysis (DTA), Fourier Transform Infrared (FTIR) Spectroscopy, X-Ray Diffractometry (XRD) and Scanning Electron Microscopy (SEM) while dissolution test was carried out using Type I Dissolution Apparatus operated at 100 rpm and in 900 mL of CO2-free water medium at a temperature of 37 ± 0.5 ◦C. Sampling was carried out at 5, 10, 15, 20, 30, 45, and 60 minutes. The results showed that the melting point, infrared absorption and crystallinity of the acetone recrystallized carbamazepine did not show significant changes compared with the initial carbamazepine compound. The morphology of the recrystallized carbamazepine crystals using the two methods produced a polycrystalline structure which influenced the rate of dissolution. The dissolution rate of acetone recrystallized carbamazepine significantly increased the dissolution of carbamazepine, with a faster dissolution rate for carbamazepine recrystallized using rapid cooling method than the solvent evaporation method or the initial carbamazepine compound.

Keywords: carbamazepine, characterization, recrystallization, acetone, solvent, dissolution

Suggested Citation

Isadiartuti, Dewi and Radjaram, A. and Handini, P.D., Characterization of Recrystallized Carbamazepine Using Acetone as Solvent (September 30, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018, Available at SSRN: https://ssrn.com/abstract=3478432 or http://dx.doi.org/10.2139/ssrn.3478432

Dewi Isadiartuti (Contact Author)

Faculty of Pharmacy, Airlangga University ( email )

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

A. Radjaram

Faculty of Pharmacy, Airlangga University

Jl. Darmawangsa Dalam 2
Surabaya, 60286
Indonesia
5033710 (Phone)
60115 (Fax)

P.D. Handini

Faculty of Pharmacy, Airlangga University

Jl. Darmawangsa Dalam 2
Surabaya, 60286
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

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