Kojic Acid Penetration: Effect of Carbomer - Tween 80 Agregate Formation

6 Pages Posted: 31 Oct 2019 Last revised: 6 Dec 2019

See all articles by N. Rosita

N. Rosita

Faculty of Pharmacy, Airlangga University

S.E. Jayanti

Faculty of Pharmacy, Airlangga University

T. Erawati

Faculty of Pharmacy, Airlangga University

Date Written: September 30, 2019

Abstract

Kojic acid is well known as a depigmentation agent is used for hyper-pigmentation therapy. The objective of this study was to determine the effect of Carbomer-Tween 80 aggregate on kojic acid penetration. Kojic acid is quickly absorbed through the skin, remaining on the epidermis not long enough to inhibit melanogenesis activities; Carbomer-Tween 80 aggregate was used to control the release of kojic acid. Tween 80 was added in different concentrations (0.01% for F1, 0.02% for F2, and 0.04% for F3) to carbomer (0.25%) dispersion to create aggregate, then the aggregate was added to a vanishing cream base. Kojic acid penetration was observed by measuring the inhibition activity of tyrosinase. The inhibitor activity was determined by measuring the absorbance of dopachrome, a product of tyrosinase reacting to L-tyrosine as a substrate, and with kojic acid as an inhibitor. The value of inhibition percentage for the formulas without Carbomer-Tween 80 aggregates, F1, F2, and F3 was 64.8367 ± 3.16, 67.2833 ± 1.89, 71.0867 ± 4.05, and 49.2867±2.75%, respectively. The inhibition percent of F3 (with addition of 0.04% Tween 80) was significantly lower than the others, demonstrating that increasing Tween 80 concentrations decreases kojic acid penetration.

Keywords: kojic acid, carbomer-tween 80 aggregation, penetration

Suggested Citation

Rosita, N. and Jayanti, S.E. and Erawati, T., Kojic Acid Penetration: Effect of Carbomer - Tween 80 Agregate Formation (September 30, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018, Available at SSRN: https://ssrn.com/abstract=3478500 or http://dx.doi.org/10.2139/ssrn.3478500

N. Rosita

Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

S.E. Jayanti

Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

T. Erawati (Contact Author)

Faculty of Pharmacy, Airlangga University ( email )

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

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