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Layer-Specific Contributions to Imagined and Executed Hand Movements in Human Primary Motor Cortex

22 Pages Posted: 8 Nov 2019 Sneak Peek Status: Review Complete

See all articles by Andrew Steven Persichetti

Andrew Steven Persichetti

National Institutes of Health - Laboratory of Brain and Cognition

Jason A. Avery

National Institutes of Health - Laboratory of Brain and Cognition

Laurentius Huber

Maastricht University - Maastricht Brain Imaging Center

Elisha P. Merriam

National Institutes of Health - Laboratory of Brain and Cognition

Alex Martin

National Institutes of Health - Laboratory of Brain and Cognition

More...

Abstract

Although it is well established that imagined motor actions can affect motor performance, the neural mechanism underpinning this relationship is unknown. Using a powerful new, non-BOLD method for collecting fMRI data, called vascular space occupancy (VASO), we were able to measure layer-specific neural activations in the primary motor cortex (M1) while participants either tapped their thumb and forefinger together or simply imagined doing so. We report that, while executed movements elicited neural responses in both superficial and deep layers of M1, imagined movements elicited responses in superficial layers only. Furthermore, imagined actions produced layer-specific repetition suppression and enhancement effects on finger tapping, thus providing evidence for a mechanism whereby imagined movements can directly affect motor performance.

Keywords: fMRI, motor Imagery, Primary Motor Cortex, cortical layers, repetition suppression, priming, VASO

Suggested Citation

Persichetti, Andrew Steven and Avery, Jason A. and Huber, Laurentius and Merriam, Elisha P. and Martin, Alex, Layer-Specific Contributions to Imagined and Executed Hand Movements in Human Primary Motor Cortex (November 8, 2019). CURRENT-BIOLOGY-D-19-01844. Available at SSRN: https://ssrn.com/abstract=3482808 or http://dx.doi.org/10.2139/ssrn.3482808
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Andrew Steven Persichetti (Contact Author)

National Institutes of Health - Laboratory of Brain and Cognition ( email )

6001 Executive Boulevard, Rm. 7117, MSC 9629
Bethesda, MA 20892
United States

Jason A. Avery

National Institutes of Health - Laboratory of Brain and Cognition

9000 Rockville Pike
Bethesda, MD 20892
United States

Laurentius Huber

Maastricht University - Maastricht Brain Imaging Center

Netherlands

Elisha P. Merriam

National Institutes of Health - Laboratory of Brain and Cognition

9000 Rockville Pike
Bethesda, MD 20892
United States

Alex Martin

National Institutes of Health - Laboratory of Brain and Cognition

9000 Rockville Pike
Bethesda, MD 20892
United States

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