The Effect of Different Ratios of the Hydrophilic Polymers Sodium Alginate 20cP and Hydroxy Propyl Methyl Cellulose E15 on the Physicochemical Characteristics of Meloxicam Patch

5 Pages Posted: 19 Nov 2019 Last revised: 6 Dec 2019

See all articles by E. Hendradi

E. Hendradi

Faculty of Pharmacy, Airlangga University

A.I.K.E. Riantiny

Faculty of Pharmacy, Airlangga University

J. Hasiholan

Faculty of Pharmacy, Airlangga University

Andang Miatmoko

Airlangga University

Date Written: October 1, 2019

Abstract

Meloxicam is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) often used for osteoarthritis treatment. However, long-term use of meloxicam can cause side effects within the digestive tract, such as ulceration of the gastric mucosa. Transdermal patches offer an alternative route to reduce the side effects of meloxicam. This study aimed to determine the effect that different ratios of hydrophilic polymers had on the physicochemical characteristics of meloxicam patches. The hydrophilic polymers used were Sodium alginate 20 cP and Hydroxy Propyl Methyl Cellulose (HPMC) E15. Several comparisons were made between the hydrophobic polymer Ethyl Cellulose (EC) N22 including F1 (4:6:1), F2 (4,5:5:1,5), F3 (5:5:1) and F4 (5:4,5:1,5) which were made by a solvent evaporation method. Patches were then evaluated for their physicochemical properties, including organoleptic characteristics, moisture content, surface homogeneity, drug homogeneity, and assay testing. The results showed that increases in HPMC concentration can increase the results obtained. Based on statistical analysis results, no significant differences between the four formulas were found. In conclusion, a combination of HPMC E15, sodium alginate 20cP, and EC N22 with the most HPMC E15 produced the highest physicochemical characteristics.

Keywords: meloxicam, patch, hydroxy propyl methyl cellulose, sodium alginate, ethyl cellulose

Suggested Citation

Hendradi, E. and Riantiny, A.I.K.E. and Hasiholan, J. and Miatmoko, Andang, The Effect of Different Ratios of the Hydrophilic Polymers Sodium Alginate 20cP and Hydroxy Propyl Methyl Cellulose E15 on the Physicochemical Characteristics of Meloxicam Patch (October 1, 2019). Proceedings of International Conference on Applied Pharmaceutical Sciences (ICoAPS) 2018. Available at SSRN: https://ssrn.com/abstract=3489586 or http://dx.doi.org/10.2139/ssrn.3489586

E. Hendradi (Contact Author)

Faculty of Pharmacy, Airlangga University ( email )

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

A.I.K.E. Riantiny

Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

J. Hasiholan

Faculty of Pharmacy, Airlangga University

FF UNAIR Kampus C UNAIR
Surabaya, East Java 60115
Indonesia
5033710 (Phone)
60115 (Fax)

HOME PAGE: http://ff.unair.ac.id/

Andang Miatmoko

Airlangga University ( email )

Jl. Darmawangsa Dalam 2
Surabaya, 60286
Indonesia

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