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Maternal Serum Metals Exposure Pattern By Metallomics Profiling and Risk of Preterm Birth in Rural Bangladesh

78 Pages Posted: 10 Dec 2019

See all articles by Yongyue Wei

Yongyue Wei

Nanjing Medical University - State Key Laboratory of Reproductive Medicine; Nanjing Medical University - Department of Biostatistics

Hui Huang

Nanjing Medical University - Department of Biostatistics

Yankai Xia

Nanjing Medical University - School of Public Health; Nanjing Medical University - State Key Laboratory of Reproductive Medicine; Nanjing Medical University - Key Laboratory of Modern Toxicology

Liangmin Wei

Nanjing Medical University - State Key Laboratory of Reproductive Medicine; Nanjing Medical University - Department of Biostatistics

Xin Chen

Nanjing Medical University - Department of Biostatistics

Ruyang Zhang

Nanjing Medical University - China International Cooperation Center for Environment and Human Health; Nanjing Medical University - Department of Biostatistics

Weiwei Duan

Nanjing Medical University - Department of Biostatistics

Li Su

Harvard University - Department of Environmental Health

Mohammad L. Rahman

Harvard University - Harvard Medical School

Mahmudur Rahman

Dhaka Community Hospital Trust

Md. Golam Mostofa

Dhaka Community Hospital Trust

Quazi Qamruzzaman

Dhaka Community Hospital Trust

Wenhui Guo

Nanjing Medical University - Key Laboratory of Modern Toxicology

Xian Sun

Nanjing Medical University - Key Laboratory of Modern Toxicology

Hao Yu

Nanjing Medical University - Department of Biostatistics

Hongbin Shen

Nanjing Medical University - China International Cooperation Center for Environment and Human Health

Zhibin Hu

Nanjing Medical University - State Key Laboratory of Reproductive Medicine

David C. Christiani

Nanjing Medical University - China International Cooperation Center for Environment and Human Health; Harvard University - Department of Environmental Health

Feng Chen

Nanjing Medical University - State Key Laboratory of Reproductive Medicine; Nanjing Medical University - China International Cooperation Center for Environment and Human Health; Nanjing Medical University - Department of Biostatistics

More...

Abstract

Background: The prevalence of preterm birth in Bangladesh is estimated to be 19·1%, the highest in the world. Although, prenatal exposure to several metals has been linked with preterm birth, fewer prospective studies have investigated multiple metals simultaneously or potential interaction between metals.

Methods: This study included data from 780 mother-offspring pairs recruited in a well-established prospective birth cohort in Bangladesh. Serum concentrations of 19 metals were measured in first and second trimesters using inductively coupled plasma mass spectrometry. Logistic regression and mediation analyses were used to investigate the crucial metals and their exposure windows and interactions, as well as mediating role of the metals.

Findings: Maternal exposure to zinc, arsenic, and strontium in the first trimester and exposure to barium in the second trimester were significantly associated with preterm risk. Zinc in the first trimester showed antagonistic effect against arsenic toxicity in the first (ORinteraction= 0·35; 95% CI: 0·12–0·97) and second (ORinteraction= 0·31; 95% CI: 0·11–0·90) trimesters. Furthermore, low marriage age was associated with an exponential increase in the risk of preterm, while 30.16% of its risk effect was mediated through affecting these four metal concentrations.

Interpretation: Multiple maternal serum metals are individually and interactively associated with the risk of preterm during pregnancy. The findings suggest that zinc supplementation at early pregnancy might attenuate the risk of preterm attributed to prenatal arsenic exposure.

Funding: Funding of China Ministry of Science and Technology and the U.S. National Institutes of Health.

Declaration of Interest: All authors declare no competing interests

Ethical Approval: All protocols were reviewed and approved by the Human Research Committees at Harvard T.H. Chan School of Public Health, Nanjing Medical University, and Dhaka Community Hospital Trust.

Keywords: metal exposure; preterm birth; inductively coupled plasma mass spectrometry

Suggested Citation

Wei, Yongyue and Huang, Hui and Xia, Yankai and Wei, Liangmin and Chen, Xin and Zhang, Ruyang and Duan, Weiwei and Su, Li and Rahman, Mohammad L. and Rahman, Mahmudur and Mostofa, Md. Golam and Qamruzzaman, Quazi and Guo, Wenhui and Sun, Xian and Yu, Hao and Shen, Hongbin and Hu, Zhibin and Christiani, David C. and Chen, Feng, Maternal Serum Metals Exposure Pattern By Metallomics Profiling and Risk of Preterm Birth in Rural Bangladesh (11/25/2019). Available at SSRN: https://ssrn.com/abstract=3494380 or http://dx.doi.org/10.2139/ssrn.3494380

Yongyue Wei

Nanjing Medical University - State Key Laboratory of Reproductive Medicine ( email )

Nanjing
China

Nanjing Medical University - Department of Biostatistics ( email )

Nanjing
China

Hui Huang

Nanjing Medical University - Department of Biostatistics

Nanjing
China

Yankai Xia

Nanjing Medical University - School of Public Health

Nanjing
China

Nanjing Medical University - State Key Laboratory of Reproductive Medicine ( email )

Nanjing
China

Nanjing Medical University - Key Laboratory of Modern Toxicology ( email )

Nanjing
China

Liangmin Wei

Nanjing Medical University - State Key Laboratory of Reproductive Medicine

Nanjing
China

Nanjing Medical University - Department of Biostatistics

Nanjing
China

Xin Chen

Nanjing Medical University - Department of Biostatistics

Nanjing
China

Ruyang Zhang

Nanjing Medical University - China International Cooperation Center for Environment and Human Health ( email )

Nanjing
China

Nanjing Medical University - Department of Biostatistics ( email )

Nanjing
China

Weiwei Duan

Nanjing Medical University - Department of Biostatistics

Nanjing
China

Li Su

Harvard University - Department of Environmental Health

401 Park Dr
Boston, MA 02215
United States

Mohammad L. Rahman

Harvard University - Harvard Medical School

25 Shattuck St
Boston, MA 02115
United States

Mahmudur Rahman

Dhaka Community Hospital Trust

Dhaka 1217, Bangladesh
India

Md. Golam Mostofa

Dhaka Community Hospital Trust

Dhaka 1217, Bangladesh
India

Quazi Qamruzzaman

Dhaka Community Hospital Trust

Dhaka 1217, Bangladesh
India

Wenhui Guo

Nanjing Medical University - Key Laboratory of Modern Toxicology

Nanjing
China

Xian Sun

Nanjing Medical University - Key Laboratory of Modern Toxicology

Nanjing
China

Hao Yu

Nanjing Medical University - Department of Biostatistics

Nanjing
China

Hongbin Shen

Nanjing Medical University - China International Cooperation Center for Environment and Human Health

Nanjing
China

Zhibin Hu

Nanjing Medical University - State Key Laboratory of Reproductive Medicine ( email )

Nanjing
China

David C. Christiani

Nanjing Medical University - China International Cooperation Center for Environment and Human Health ( email )

Nanjing
China

Harvard University - Department of Environmental Health ( email )

401 Park Dr
Boston, MA 02215
United States

Feng Chen (Contact Author)

Nanjing Medical University - State Key Laboratory of Reproductive Medicine ( email )

Nanjing
China

Nanjing Medical University - China International Cooperation Center for Environment and Human Health ( email )

Nanjing
China

Nanjing Medical University - Department of Biostatistics ( email )

Nanjing
China

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