Incorporating Redox-Sensitive Nanogels into Bioabsorbable Nanofibrous Membrane to Acquire ROS-Balance Capacity for Skin Regeneration

24 Pages Posted: 6 Dec 2019

See all articles by Yulin Li

Yulin Li

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Xiaofeng Qiu

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Anqi Jiao

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Xiajie Lin

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Xiaohui Zhang

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Zeren Zhang

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Jiachan Hong

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Changsheng Liu

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

Date Written: November 28, 2019

Abstract

Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly via adjustment of immune response and neovasculation. In this study, we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy. Firstly, redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker. The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid) (PLLA) via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity. In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane. In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process, where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.

Keywords: Polylactide, Nanofibrous membrane, Redox sensitivity, ROS-balance, Skin regeneration

Suggested Citation

Li, Yulin and Qiu, Xiaofeng and Jiao, Anqi and Lin, Xiajie and Zhang, Xiaohui and Zhang, Zeren and Hong, Jiachan and Liu, Changsheng, Incorporating Redox-Sensitive Nanogels into Bioabsorbable Nanofibrous Membrane to Acquire ROS-Balance Capacity for Skin Regeneration (November 28, 2019). Available at SSRN: https://ssrn.com/abstract=3494600 or http://dx.doi.org/10.2139/ssrn.3494600

Yulin Li (Contact Author)

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education ( email )

China

Xiaofeng Qiu

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education ( email )

China

Anqi Jiao

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

Xiajie Lin

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

Xiaohui Zhang

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

Zeren Zhang

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

Jiachan Hong

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

Changsheng Liu

East China University of Science and Technology (ECUST) - Key Laboratory for Ultrafine Materials of Ministry of Education

China

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