Highly Porous Poly (N-Isopropylacrylamide) Hydrogels With Rapid Deswelling Properties

Posted: 2 Dec 2019

See all articles by MB Dharmasiri

MB Dharmasiri

Department of Chemistry, Faculty of Applied Sciences

TK Mudiyanselage

University of Sri Jayewardenepura - Department of Polymer Science

Date Written: December 2, 2019

Abstract

Stimuli-responsive materials are beneficial in a myriad of applications, including biosensing and biomaterials, actuation, and in controlled drug delivery systems. Temperature responsive materials have been among the most broadly studied. Thermo-responsive PNIPAM has attracted a tremendous focus as it can be triggered at physiologically significant temperatures, but its applications have been greatly limited because of the long response time. Fast responding PNIPAM hydrogels were synthesised by manipulating the phase separation technique. Highly porous PNIPAM hydrogels with very short response time were prepared by emulsion templated polymerization, (2.5 M NIPAM monomer solution was crosslinked with 1% N,N-methylene bisacrylamide using 5% potassium persulfate as the initiator. Virgin coconut oil (70% v/v) was used as the pore-forming agent, dispersed in the aqueous monomer solution by 5% tween80 (non-ionic surfactant) followed by subsequent removal of the oil by refluxing in acetone. This resulted in an extremely macro-porous hydrogel as vivid in the SEM studies. The response time has been reduced due to interconnected macro-pores which function as effective water release channels. Swelling ratio studies showed that the physically modified hydrogel dwells more than 85% of its total volume of water at equilibrium swollen state in 15 seconds upon increasing temperature above the volume phase transition temperature (VPTT). This is approximately seven times faster than the response rate of the hydrogel synthesised by the conventional method. The extreme porous structure did not influence the VPTT of the hydrogel. This PNIPAM hydrogel with extremely fast responding rate has promising potential for advanced applications predominantly in the field of medicine.

Keywords: N-isopropylacrylamide, thermo-responsive, fast deswelling, microporous, emulsion templated polymerization

Suggested Citation

Dharmasiri, MB and Mudiyanselage, TK, Highly Porous Poly (N-Isopropylacrylamide) Hydrogels With Rapid Deswelling Properties (December 2, 2019). Proceedings of the 6th International Conference on Multidisciplinary Approaches (iCMA) 2019 | Faculty of Graduate Studies, University of Sri Jayewardenepura. Available at SSRN: https://ssrn.com/abstract=3496503

MB Dharmasiri

Department of Chemistry, Faculty of Applied Sciences ( email )

Sri Lanka

TK Mudiyanselage (Contact Author)

University of Sri Jayewardenepura - Department of Polymer Science ( email )

Sri Soratha Mawatha
Nugegoda, 10250
Sri Lanka

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