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Oxytocin Controls Male Sexual Activity  via Non-Synaptic Axonal Release in the Spinal Cord

61 Pages Posted: 21 Jan 2020 Sneak Peek Status: Review Complete

See all articles by Takumi Oti

Takumi Oti

Okayama University - Ushimado Marine Institute (UMI)

Keita Satoh

Okayama University - Ushimado Marine Institute (UMI)

Daisuke Uta

University of Toyama - Department of Applied Pharmacology

Junta Nagafuchi

Okayama University - Ushimado Marine Institute (UMI)

Ryota Ueda

Okayama University - Ushimado Marine Institute (UMI)

Keiko Takanami

Okayama University - Ushimado Marine Institute (UMI)

Larry J. Young

Emory University - Center for Translational Social Neuroscience

Antony Galione

University of Oxford - Department of Pharmacology

John F. Morris

University of Oxford - Department of Physiology, Anatomy and Genetics

Tatsuya Sakamoto

Okayama University - Ushimado Marine Institute (UMI)

Hirotaka Sakamoto

Okayama University - Ushimado Marine Institute (UMI)

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Abstract

There is considerable current interest concerning the role of the neuropeptide oxytocin in the regulation of socio-sexual behaviors in mammals, ranging from social bonding  to empathy. However, the precise mechanisms by which sparsely dispersed oxytocin fibers in the central nervous system lead to activation of distributed receptor populations are unclear. Here we present evidence, in rats, that release of oxytocin in the lumbar spinal cord is not limited to synapses, but occurs from axonal varicosities and acts by diffusion – a localized volume transmission – to reach oxytocin receptors and facilitate male sexual function. Although somato-dendritic release of oxytocin has been reported in the hypothalamus, our findings demonstrate for the first time that extra-synaptic release occurs from axons in the spinal cord, far distant from the somata and dendrites, to modulate male sexual activity during copulatory behavior.

Keywords: oxytocin, localized volume transmission, spinal cord, male sexual activity

Suggested Citation

Oti, Takumi and Satoh, Keita and Uta, Daisuke and Nagafuchi, Junta and Ueda, Ryota and Takanami, Keiko and Young, Larry J. and Galione, Antony and Morris, John F. and Sakamoto, Tatsuya and Sakamoto, Hirotaka, Oxytocin Controls Male Sexual Activity  via Non-Synaptic Axonal Release in the Spinal Cord. CURRENT-BIOLOGY-D-19-02138. Available at SSRN: https://ssrn.com/abstract=3515384 or http://dx.doi.org/10.2139/ssrn.3515384
This is a paper under consideration at Cell Press and has not been peer-reviewed.

Takumi Oti

Okayama University - Ushimado Marine Institute (UMI)

Japan

Keita Satoh

Okayama University - Ushimado Marine Institute (UMI)

Japan

Daisuke Uta

University of Toyama - Department of Applied Pharmacology

Japan

Junta Nagafuchi

Okayama University - Ushimado Marine Institute (UMI)

Japan

Ryota Ueda

Okayama University - Ushimado Marine Institute (UMI)

Japan

Keiko Takanami

Okayama University - Ushimado Marine Institute (UMI)

Japan

Larry J. Young

Emory University - Center for Translational Social Neuroscience

United States

Antony Galione

University of Oxford - Department of Pharmacology

United Kingdom

John F. Morris

University of Oxford - Department of Physiology, Anatomy and Genetics

United Kingdom

Tatsuya Sakamoto

Okayama University - Ushimado Marine Institute (UMI)

Japan

Hirotaka Sakamoto (Contact Author)

Okayama University - Ushimado Marine Institute (UMI) ( email )

Japan

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