cAMP-Dependent Co-Stabilization of Axonal Arbors from Adjacent Developing Neurons
33 Pages Posted: 10 Jan 2020 Sneak Peek Status: Under ReviewMore...
Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize their connections, but the demonstration of such interactions is lacking. Here we provide experimental evidence that reducing cAMP signaling in a subset of retinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization.
Keywords: competition, cooperation, retina, pruning, retinal ganglion cells, spontaneous activity, dorso-lateral geniculate nucleus, axon
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