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Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China

26 Pages Posted: 27 Jan 2020

See all articles by Nanshan Chen

Nanshan Chen

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

Min Zhou

Shanghai Jiao Tong University (SJTU)

Xuan Dong

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

Jieming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine

Fengyun Gong

Wuhan Jinyintan Hospital

Yang Han

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Yang Qiu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Jingli Wang

Wuhan Jinyintan Hospital

Ying Liu

Wuhan Jinyintan Hospital

Yuan Wei

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

Jia'an Xia

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

Ting Yu

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

Xinxin Zhang

Shanghai Jiao Tong University (SJTU) - Research Laboratory of Clinical Virology

Li Zhang

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

More...

Abstract

Background: Since December 2019, a novel coronavirus (2019-nCoV) associated pneumonia has emerged in Wuhan, China. The study aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.

Methods: 99 cases admitted to Wuhan Jinyintan Hospital during January 1 to 20, 2020 and confirmed by real-time reverse-transcriptase polymerase-chain-reaction (RT-PCR) test were analyzed for epidemiological, demographic, clinical, radiological features, and laboratory data.

Findings: Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the South China Seafood Wholesale Market. The average age of the patients was 62.85 ± 11.99 years, including 67 males and 32 females. 2019-nCoV was detected in all patients by RT-PCR, and some of them also by serological testing, and metagenomics sequencing analysis. 50 cases (50.51%) had chronic basic diseases. Patients had clinical manifestations of fever (83%), cough (82%), shortness of breath (31%), muscle aches (11%), headache (8%), fuzzy confusion (7%), chest pain (2%), and diarrhea (2%). According to imaging examination, 74 patients showed bilateral pneumonia (74.75%), 25 patients showed multiple mottled and ground-glass opacity, and 1 patient had pneumothorax. Most patients received antiviral, antibiotics, supportive treatments, continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO), and had good prognosis. 17 patients developed acute Respiratory Distress Syndrome (ARDS) and among them, 2 patients worsened in a short period of time and died of multiple organ failure.

Interpretation: The infection of the 2019-nCoV can result in severe and even fatal respiratory disease like ARDS. It is very important to actively prevent complications and secondary infections, treat underlying diseases, and provide timely organ function support. Early diagnosis, early isolation, multiple treatment, and intervention of CRRT and ECMO when necessary can effectively reduce mortality caused by severe coronavirus pneumonia.

Funding: National Key R&D Program of China (No. 2017YFC1309700)

Declaration of Interest: The author reports no conflicts of interest in this work.

Ethical Approval: The study was approved by Jinyintan Hospital Ethics Committee and written informed consent was obtained from all patients involved before enrolment.

Keywords: novel coronavirus; 2019-nCoV pneumonia; diagnosis; treatment

Suggested Citation

Chen, Nanshan and Zhou, Min and Dong, Xuan and Qu, Jieming and Gong, Fengyun and Han, Yang and Qiu, Yang and Wang, Jingli and Liu, Ying and Wei, Yuan and Xia, Jia'an and Yu, Ting and Zhang, Xinxin and Zhang, Li, Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China (1/21/2020). Available at SSRN: https://ssrn.com/abstract=3523861

Nanshan Chen

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

China

Min Zhou

Shanghai Jiao Tong University (SJTU)

KoGuan Law School
Shanghai 200030, Shanghai 200052
China

Xuan Dong

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

China

Jieming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine

China

Fengyun Gong

Wuhan Jinyintan Hospital

China

Yang Han

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Wuhan, 430071
China

Yang Qiu

Chinese Academy of Sciences (CAS) - State Key Laboratory of Virology

Wuhan, 430071
China

Jingli Wang

Wuhan Jinyintan Hospital

China

Ying Liu

Wuhan Jinyintan Hospital

China

Yuan Wei

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

China

Jia'an Xia

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

China

Ting Yu

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory

China

Xinxin Zhang

Shanghai Jiao Tong University (SJTU) - Research Laboratory of Clinical Virology ( email )

Ruijin Er Road 197
Shanghai, 200025
China

Li Zhang (Contact Author)

Wuhan Jinyintan Hospital - Department of Tuberculosis and Respiratory ( email )

China

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