cNMA and Fuzzy -Logic Based Ligand Screening for Preventing Myocardial Lipid Accumulation in Pressure-Overload Cardiac Hypertrophy and Metabolic Syndrome
Posted: 4 Feb 2020
Date Written: February 1, 2020
Inherited and acquired cardiomyopathy due to obesity and diabetes results in impaired lipid accumulation in the myocyte. Lipid accumulation in the heart leads to its death(Heart failure) by non-oxidative and oxidative metabolic pathways. Identification of the appropriate proteins which are rate limiting factor for lipid accumulation and suitable antagonist screening methods using conventional normal mode analysis based on anisotrophic network and adaptive Neuro-Fuzzy Inference System are discussed in this paper.
Keywords: Cardiac Hypertrophy, Inhibitor Metabolic Syndrome, Lipid Accumulation pathway, Heart Failure, Antagonist Screening, Anisotrophic Network Model
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