More Than Pneumonia, The Potential Occurrence of Multiple Organ Failure in 2019 Novel Coronavirus Infection

4 Pages Posted: 5 Feb 2020

See all articles by Ming Yang

Ming Yang

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong

Jinming Zhao

Capital Medical University - Department of Otorhinolaryngology Head and Neck Surgery

Zheng Zhang

Department of Cardiology, PLA Rocket Force Characteristic Medical Center

Date Written: February 5, 2020

Abstract

Angiotensin converting enzyme 2 (ACE2) in the lung has been recognized as the key receptor of the 2019 novel coronavirus (2019-nCoV) as people may get infected through the respiratory tract. However, the clinical features of other systems have not been addressed yet. More than the respiratory system, ACE2 also extensively expressed in the vascular endothelial cells of the heart, kidney, liver, intestine, and testis, etc. In other words, the new coronavirus may probably intrude on any tissues or organs as long as the needed number of ACE2 is available. Therefore, once exposed to the coronavirus (e.g. through the blood or other body fluid), these organs may also get affected especially for those the receptor has the direct-acting control. This paper aims to analyze the possibility of the association between 2019-nCoV infection and the multiple organ failure (MOF) other than pneumonia.

Keywords: Angiotensin converting enzyme 2 (ACE2), 2019 novel coronavirus (2019-nCoV), blood-air barrier, multiple organ failure(MOF)

Suggested Citation

Yang, Ming and Zhao, Jinming and Zhang, Zheng, More Than Pneumonia, The Potential Occurrence of Multiple Organ Failure in 2019 Novel Coronavirus Infection (February 5, 2020). Available at SSRN: https://ssrn.com/abstract=3532272 or http://dx.doi.org/10.2139/ssrn.3532272

Ming Yang (Contact Author)

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong ( email )

Room 406, HKJC BIR Buildling
No.5 Sassoon Rd, Hong Kong Island
Hong Kong
Hong Kong

Jinming Zhao

Capital Medical University - Department of Otorhinolaryngology Head and Neck Surgery ( email )

Beijing, 100730
China

Zheng Zhang

Department of Cardiology, PLA Rocket Force Characteristic Medical Center ( email )

Beijing, 100088
China

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
808
Abstract Views
7,656
rank
36,286
PlumX Metrics