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Clinical Features and Computed Tomographic Manifestations of Patients with 2019 Novel Coronavirus Pneumonia: A Single Center Study in Shanghai, China

22 Pages Posted: 11 Feb 2020

See all articles by Wenjie Yang

Wenjie Yang

Shanghai Jiao Tong University (SJTU) - Department of Radiology

Zenghui Cheng

Shanghai Jiao Tong University (SJTU) - Department of Radiology

Qiqi Cao

Shanghai Jiao Tong University (SJTU)

Zhitao Yang

Shanghai Jiao Tong University (SJTU) - Department of Emergency

Huijuan Zhou

Shanghai Jiao Tong University (SJTU) - Department of Infectious Diseases

Le Qin

Shanghai Jiao Tong University (SJTU) - Department of Radiology

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine

Yong Lu

Shanghai Jiao Tong University (SJTU) - Department of Radiology

Fuhua Yan

Shanghai Jiao Tong University (SJTU) - Department of Radiology

More...

Abstract

Background: To study the clinical features and CT manifestations of patients with confirmed 2019-nCoV pneumonia and compare between patients with and without 2019-nCoV infection among all the suspects during the pandemic period.

Methods: The patients were enrolled from Jan 20 to Feb 1, 2020, at the fever observation department. All the patients with suspected 2019-nCoV infection were tested by RT-­PCR. All the clinical data, laboratory results, imaging findings on CT was retrospectively reviewed.

Findings: Seven patients were confirmed 2019­nCoV positive while 21 patients were negative. No statistical difference was observed in all the clinical features between these 2 groups (p> 0.05). All the positive patients had pulmonary infiltrations, located predominantly in the peripheral zone compared with negative group (100% vs. 43.75%, p=0.02). The number of infiltrated lung lobes and segments in the positive group were higher than that in the negative group (5/12 vs. 2/4, p=0.00/0.00), and more right lower lung segments were affected in the positive group although no significant difference was observed (71.43% vs. 28.57%, p=0.08). Air bronchogram was more frequent in the positive group (100% vs. 19.50%, p=0.00), and the tree-in-bud sign was less common (14.29% vs. 19.05%, p=0.00).

Interpretation: The imaging pattern of multifocal patchy peripheral pure ground glass opacity (GGO), mixed GGO or consolidation predominant in the lower lung, with more extensive GGO than consolidation in CT scans within the first week of illness is highly suspicious of 2019-nCoV infection during the outbreak, which may be crucial for early treatment and prompt isolation.

Funding: No funding.

Declaration of Interest: The authors of this study declare that they each have no conflict of interest.

Ethical Approval: This retrospective study was approved by our Institutional Review Board (KY2020-26). The written informed consent was waived.

Keywords: Computed tomography; novel coronavirus; viral pneumonia

Suggested Citation

Yang, Wenjie and Cheng, Zenghui and Cao, Qiqi and Yang, Zhitao and Zhou, Huijuan and Qin, Le and Qu, Jie-ming and Lu, Yong and Yan, Fuhua, Clinical Features and Computed Tomographic Manifestations of Patients with 2019 Novel Coronavirus Pneumonia: A Single Center Study in Shanghai, China (2/5/2020). Available at SSRN: https://ssrn.com/abstract=3534223 or http://dx.doi.org/10.2139/ssrn.3534223

Wenjie Yang

Shanghai Jiao Tong University (SJTU) - Department of Radiology

China

Zenghui Cheng

Shanghai Jiao Tong University (SJTU) - Department of Radiology

China

Qiqi Cao

Shanghai Jiao Tong University (SJTU)

KoGuan Law School
Shanghai 200030, Shanghai 200052
China

Zhitao Yang

Shanghai Jiao Tong University (SJTU) - Department of Emergency

Shanghai, 200025
China

Huijuan Zhou

Shanghai Jiao Tong University (SJTU) - Department of Infectious Diseases

China

Le Qin

Shanghai Jiao Tong University (SJTU) - Department of Radiology

China

Jie-ming Qu

Shanghai Jiao Tong University (SJTU) - Department of Respiratory and Critical Care Medicine ( email )

China

Yong Lu

Shanghai Jiao Tong University (SJTU) - Department of Radiology ( email )

China

Fuhua Yan (Contact Author)

Shanghai Jiao Tong University (SJTU) - Department of Radiology ( email )

China

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