The Role of Angiotensin Converting Enzyme 2 in Coronaviruses/Influenza Viruses and Cardiovascular Disease

Posted: 18 Feb 2020

See all articles by Li Chen

Li Chen

Augusta University - Medical College of Georgia

Guang Hao

Jinan University - Department of Epidemiology

Date Written: February 14, 2020

Abstract

Angiotensin-converting enzyme 2 (ACE2) has emerged as a key regulator of the renin-angiotensin system in cardiovascular (CV) disease and plays a pivotal role in coronaviruses and influenza viruses infections. The present review is primarily focused on the findings to indicate the role of ACE2 in the relationship between coronaviruses and influenza viruses with CV disease. It is postulated that the risk of coronavirus or influenza virus infection is high, at least partly, due to high ACE2 expression in population with high CV risk. Coronaviruses and influenza viruses vaccine usage in high CV risk population could be a potential strategy to prevent both CV disease and coronaviruses or influenza viruses infections.

Funding: The authors received no financial support for the authorship or publication of this article.

Declaration of Interest: Dr. Chen has nothing to disclose. Dr. Hao has nothing to disclose.

Keywords: Angiotensin-converting enzyme 2; cardiovascular disease; coronaviruses; influenza viruses

Suggested Citation

Chen, Li and Hao, Guang, The Role of Angiotensin Converting Enzyme 2 in Coronaviruses/Influenza Viruses and Cardiovascular Disease (February 14, 2020). Available at SSRN: https://ssrn.com/abstract=3537961 or http://dx.doi.org/10.2139/ssrn.3537961

Li Chen

Augusta University - Medical College of Georgia

Kelly Building
Augusta, GA 30912
United States

Guang Hao (Contact Author)

Jinan University - Department of Epidemiology ( email )

Huang Pu Da Dao Xi 601, Tian He District
Guangzhou, Guangdong 510632
China

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