Clinical Characteristics of 5732 Patients with 2019-nCoV Infection

Abstract

Objective: to provide reliable evidence of evidence-based medicine for the treatment and prevention of the 2019 novel coronavirus (2019-nCoV) by analyzing all the published studies on the clinical characteristics of patients with 2019-nCoV.

Methods: PubMed,Cochrane Library, Embase and other databases were searched. Some studies on the clinical characteristics of 2019-nCoV infection were collected for Meta-analysis.

Results: 8 studies were included in Meta-analysis, including a total of 5732 patients with 2019-nCoV infection.According to Meta-analysis, among the clinical characteristics of patients with 2019-nCoV infection, the incidence of fever is 90.9%, the incidence of cough is 70.8%, and the incidence of muscle soreness or fatigue is 41%. The incidence of acute respiratory distress syndrome (ARDS) was 14.8%, the incidence of abnormal chest CT was 95.6%, the proportion of severe cases in all infected cases was 24.3%, and the mortality rate of patients with 2019-nCoV infection was 6.4%.

Conclusion: Fever and cough are the most common symptoms in patients with 2019-nCoV infection, and most of them have abnormal chest CT examination.Some people have muscle soreness or fatigue, ARDS. Diarrhea, hemoptysis, headache, sore throat, shock and other symptoms only occur in a small number of patients.The mortality rate of patients with 2019-nCoV infection was lower than that of Severe Acute Respiratory Syndrome (SRAS) and Middle East Respiratory Syndrome (MERS).

Funding Statement: There is no funding for our research.

Declaration of Interests: The authors have declared that there is no conflict of interest in this study.

Ethics Approval Statement: This study utilized PRISMA.

Keywords: 2019-nCoV, Coronavirus, Meta-analysis, Mortality, Clinical Symptoms