Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact email@example.com.
Epidemic Trend and Transmission Risk of SARS-CoV-2 after Government Intervention in the Mainland of China: A Mathematical Model Study
31 Pages Posted: 20 Feb 2020More...
Background: The outbreak of SARS-CoV-2 had seriously endangered the lives and health of Chinese people and brought heavy economic burden to China. We predicted the epidemic trend of COVID-19 and estimated the effectiveness of several prevention and control strategies.
Methods: According to the epidemic status of COVID-19, we constructed an SEIPQR transmission model. Based on the reported data from Jan 23 to Feb 13, we estimated model parameters and initial values. Then we predicted the epidemic trend and transmission risk of COVID-19. Using sensitivity analysis method, we estimated the impact of several intervention strategies.
Findings: The finally cumulative number of confirmed cases in the mainland of China will be 91,661 (95%CI, 91,492-91,829). Up-to March 15, the case-fatality rate will up-to 6.10% (95%CI, 5.88-6.32%). On Feb 26, the existing confirmed cases would reach its peak, with 64,128 cases (95%CI, 63,040-65,216). On Jan 23, the effective reproduction number was 2.564 (95%CI, 2.502-2.631), and had dropped below 1.0 since Feb 6. Due to government intervention, both of the total number of confirmed cases and deaths would reduce by 99.99%. If the isolation is relaxed from Feb 27, there might be a second peak of infection, with more than 457,900 cases. However, relax the isolation after Mar 2 will avoid a second peak. The total number of confirmed cases and deaths would increase by 7.08% and 9.90% by one-day delayed diagnosis in unquarantined infected patients after January 23. Moreover, if the coverage of tracing close contacts was increased to 100%, the cumulative number of confirmed cases would decrease by 81.67%.
Interpretation: The series of quarantine measures adopted by the Chinese government since January 23 were necessary and effective. Postponing the relaxation of isolation, early detection and isolation of patients, widely tracing of close contacts and strict monitoring of infected persons could effectively reduce the scale of infection and mortality.
Funding Statement: The study was supported by grants from the National Natural Science Foundation of China (11971375, 11571272, 11631012 and 11201368), grant from the National Science and Technology Major Project of China (2018ZX10721202), grant from the Natural Science Foundation of Shaanxi Province (2019JM-273), and grant from the China Postdoctoral Science Foundation (2014M560755), Fundamental Research Funds for the Central Universities (No.xzy012019107).
Declaration of Interests: The authors declared that they do not have anything to disclose regarding conflict of interest with respect to this manuscript.
Keywords: SARS-CoV-2; Transmission dynamics; Prevalence; Effective reproduction number; Intervention strategy
Suggested Citation: Suggested Citation