Preparation, Structure Elucidation, Spectral Characterization Biological Evaluation and Anticancer Activity of Novel Binary Transition Metal Complexes Derived From Ortho Amino Benzo Hydroxamic Acid

Posted: 19 Feb 2020

Date Written: February 19, 2020

Abstract

Cobalt, Nickel, Copper, Zinc acetate salts are reacted with Ortho-amino benzo hydroxamic acid (OABH) in ethanol generate tetra co-ordinate complexes with formula [M (II) (OABH) (H2O)] called as binary metal complex. Characterisation of binary metal complexes are further calculated by IR, UV-VIS, ESR, microanalysis, molar conductance, magnetic susceptibility, mass spectra and thermo gravimetric analysis (TGA).M (II) being co-ordinate by tri- dentate OABH ligand and complexes are found to be mononuclear where it is checked by experimental data through enolic oxygen, amino and the azomethine nitrogen atoms. Spectral data of UV-Vis and magnetic susceptibility have recommended the novel metal complexes shows square planar and tetrahedral geometry .Complexes are tested for their abilities in biological activity. Antimicrobial tests of the ligand and novel binary complexes have been carried out. The outcome was evaluate with some well-known antibiotics. Synthesized metal complexes are appraise for the anticancer activity in cancer cells that posses A549 (lung cancer, CCL-185), SKNSH (Human neuro blastoma cancer, CCL-131) and Hela (cervical cancer, CCL-2) gives much more promising candidate to aim further structure activity based studies.

Keywords: Binary metal complexes, spectral, ortho-amino benzo hydroxamic acid, antimicrobial, anticancer activity

Suggested Citation

Doma, Anitha and Battu, Satyanarayana, Preparation, Structure Elucidation, Spectral Characterization Biological Evaluation and Anticancer Activity of Novel Binary Transition Metal Complexes Derived From Ortho Amino Benzo Hydroxamic Acid (February 19, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020, Available at SSRN: https://ssrn.com/abstract=3541096

Anitha Doma (Contact Author)

OUCW,KOTI ( email )

Koti, Hyderabad
India

OU ( email )

Tarnaka
Osmania University
Hyderabad, 500007
India

Satyanarayana Battu

OU ( email )

Tarnaka
Osmania University
Hyderabad, 500007
India

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